Genes News and Research

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New research reveals underlying biomechanics involved in meniscus fibrocartilage function

Knee injuries are among the top five reasons people visit an orthopedic surgeon for treatments, which include 719,000 total knee replacements performed annually in the United States. Now, new research reveals underlying biomechanics that may be involved in meniscus fibrocartilage function as well as dysfunction and could guide novel treatments for some of the most debilitating and costly orthopedic problems in the U.S., including meniscus tears and age-related joint degeneration.

22 Feb 2016

FSU researchers explore new method to decipher genetic data for new prostate cancer treatments

Florida State University researchers are working on new approaches to deciphering genetic data that may lead to new, more targeted prostate cancer treatments.

22 Feb 2016

Researchers analyze how Topo II enzyme may affect stability of genomes

While researchers are now familiar with how cancer begins—cells mutate and then multiply wildly out of control—it is still uncertain exactly how that mutation starts in the molecules of the cells.

22 Feb 2016

Berlin researchers use T cells to target mutations in cancer cells

The efficacy of the immune system to combat disease makes the body's own healing powers a promising approach in the fight against cancer. A Berlin research group led by Wolfgang Uckert, Thomas Blankenstein and Matthias Leisegang has been collaborating with U.S. researcher Hans Schreiber in a project to use immune components called T cells to target mutant proteins produced by cancer cells.

22 Feb 2016

UCLA-led researchers identify specific gene network that promotes repair in peripheral nervous system

Whether or not nerve cells are able to regrow after injury depends on their location in the body. Injured nerve cells in the peripheral nervous system, such as those in the arms and legs, can recover and regrow, at least to some extent. But nerve cells in the central nervous system -- the brain and spinal cord -- can't recover at all.

22 Feb 2016

Penn researchers develop new mathematical model to estimate mutation rates in the human genome

It turns out that the type, how frequent, and where new mutations occur in the human genome depends on which DNA building blocks are nearby, found researchers from the Perelman School of Medicine at the University of Pennsylvania in an advanced online study published this week in Nature Genetics.

22 Feb 2016

Scientists find that lifespan of supportive cells in tumor may control cancer metastasis

Researchers have discovered that eliminating cells thought to aid tumor growth did not slow or halt the growth of cancer tumors. In fact, when the cancer-associated fibroblasts (CAFs), were eliminated after 10 days, the risk of metastasis of the primary tumor to the lungs and bones of mice increased dramatically.

22 Feb 2016

New article describes recent efforts made by researchers to classify bladder cancers

The ability to map the human genome has transformed how scientists and researchers classify various cancers. In the past, cancer cells were examined through a microscope and their appearance, often enhanced with dyes or other agents, was used to categorize the type of cancer.

22 Feb 2016

New study focuses on safety of using induced pluripotent stem cells in patients

A new study led by scientists at The Scripps Research Institute and the J. Craig Venter Institute shows that the act of creating pluripotent stem cells for clinical use is unlikely to pass on cancer-causing mutations to patients.

22 Feb 2016

UGA scientists discover link between genetics and aging process

Scientists at the University of Georgia have shown that a hormone instrumental in the aging process is under genetic control, introducing a new pathway by which genetics regulates aging and disease.

22 Feb 2016

Novartis receives FDA Breakthrough Therapy designation for PKC412 (midostaurin)

Novartis announced today that the United States Food and Drug Administration has granted Breakthrough Therapy designation to PKC412 (midostaurin). PKC412 (midostaurin) is an investigational treatment for adults with newly-diagnosed AML who are FLT3 mutation-positive, as detected by an FDA-approved test, and who are eligible to receive standard induction and consolidation chemotherapy.

19 Feb 2016

Researchers examine molecular profile of HPV-positive oropharyngeal squamous cell carcinoma

Throat cancer patients exposed to both human papillomavirus (HPV) and tobacco smoke demonstrate a pattern of mutations along several key cancer genes, according to research presented today at the 2016 Multidisciplinary Head and Neck Cancer Symposium.

19 Feb 2016

New method could help scientists better predict disease-causing mutations in people's genes

Two researchers at the University of Tennessee, Knoxville, have developed a method that could help clinicians and scientists better predict which mutations in people's genes could cause a disease and which would remain dormant.

18 Feb 2016

Virginia Tech experts explore new strategy to eradicate harmful viruses

With the outbreak of viruses like Zika, chikungunya, and dengue on the rise, public health officials are desperate to stop transmission.

18 Feb 2016

Caltech researchers identify gene that causes severe insomnia when overactivated

Caltech biologists have performed the first large-scale screening in a vertebrate animal for genes that regulate sleep, and have identified a gene that when overactivated causes severe insomnia. Expression of the gene, neuromedin U (Nmu), also seems to serve as nature's stimulant--fish lacking the gene take longer to wake up in the morning and are less active during the day.

18 Feb 2016

Creating NGS solutions in routine clinical diagnostics

Sophia Genetics, the global leader in Data-Driven Medicine (DDM), announced today the signing of a new strategic partnership with Integrated DNA Technologies (IDT).

From Integrated DNA Technologies 17 Feb 2016

Tackling antibiotic resistance from a new perspective

Tackling antibiotic resistance on only one front is a waste of time because resistant genes are freely crossing environmental, agricultural and clinical boundaries, new research has shown.

17 Feb 2016

Patterns of philopatry and longevity contribute to menopause, study suggests

The evolution of the menopause was 'kick-started' by a fluke of nature, but then boosted by the tendency for sons and grandsons to remain living close to home, a new study by Liverpool scientists suggests.

17 Feb 2016

FAU researchers find mechanism that promotes metastasis and causes tumours to resist treatment

Fast metastasis and resistance to treatment are characteristic of aggressive types of cancer such as pancreatic cancer and certain kinds of breast cancer. They are also the main causes of cancer-related death, as there is currently no specific treatment available that is able to stop tumours spreading throughout the whole body. Researchers at Friedrich-Alexander-Universität Erlangen-Nürnberg have recently made a discovery that could change this.

17 Feb 2016

Study reveals another clue to workings of trachoma

Another clue to the workings of trachoma - the world's leading infectious cause of blindness - has been revealed in a new study published in BMC Infectious Diseases. Researchers identified markers of genetic regulation present in the early stages of infection that could predispose children to developing the condition in its long-term, severe form.

17 Feb 2016

Genes News and Research

New research reveals underlying biomechanics involved in meniscus fibrocartilage function

FSU researchers explore new method to decipher genetic data for new prostate cancer treatments

Researchers analyze how Topo II enzyme may affect stability of genomes

Berlin researchers use T cells to target mutations in cancer cells

UCLA-led researchers identify specific gene network that promotes repair in peripheral nervous system

Penn researchers develop new mathematical model to estimate mutation rates in the human genome

Scientists find that lifespan of supportive cells in tumor may control cancer metastasis

New article describes recent efforts made by researchers to classify bladder cancers

New study focuses on safety of using induced pluripotent stem cells in patients

UGA scientists discover link between genetics and aging process

Novartis receives FDA Breakthrough Therapy designation for PKC412 (midostaurin)

Researchers examine molecular profile of HPV-positive oropharyngeal squamous cell carcinoma

New method could help scientists better predict disease-causing mutations in people's genes

Virginia Tech experts explore new strategy to eradicate harmful viruses

Caltech researchers identify gene that causes severe insomnia when overactivated

Creating NGS solutions in routine clinical diagnostics

Tackling antibiotic resistance from a new perspective

Patterns of philopatry and longevity contribute to menopause, study suggests

FAU researchers find mechanism that promotes metastasis and causes tumours to resist treatment

Study reveals another clue to workings of trachoma

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