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The SAVE initiative to monitor the impact of SARS-CoV-2 variants

The SAVE initiative assesses the impact of SARS-CoV-2 variants on diagnostics, vaccines, and therapies, as well as communicating public health dangers.

4 Apr 2022

Key protein could be a novel target for treatment of patients with B cell signaling deficiencies

The rules to the kids' game "red light, green light" are easy to follow: red always means stop, and green always means go. But now, researchers from Japan have found that a key protein involved in B cell signaling acts as both a red light to signaling in healthy cells and a green light to signaling in immune-deficient cells.

4 Apr 2022

Study investigates targeted phenotyping of host proteins aiding drug repurposing in COVID-19

Researchers conducted selective phenotyping of coronavirus disease 2019 -relevant host proteins to facilitate target identification for drug repurposing.

4 Apr 2022

The effects of SARS-CoV-2 infection in different ancestry origins from the same region

Researchers examined whether varied allelic frequencies of the HLA gene in people of different ancestral origins were associated with increased susceptibility to SARS-CoV-2 infection and disease severity.

4 Apr 2022

Evidence SARS-CoV-2 undergoes ADAR-mediated A-to-I RNA editing in human cells

In a recent study published in the journal PLOS Genetics, researchers explored severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) ribonucleic acid (RNA) editing in host cells.

4 Apr 2022

mRNA-1273 and BNT162b2 COVID-19 vaccines induce slightly different immune responses

In a recent study published in the journal Science, researchers observed differential effector functions of antibodies elicited by Pfizer’s BNT162b2 and Moderna’s messenger ribonucleic acid (mRNA)-1273 coronavirus disease 2019 (COVID-19) vaccines.

4 Apr 2022

AI helps identify areas in need of emergency aid

In a recent study published in the journal Nature, researchers developed and evaluated an approach that used machine-learning algorithms to analyze mobile phone and satellite data to estimate poverty. They aimed to optimize the ‘Novissi’ flagship emergency social assistance program in Togo, West Africa, providing subsistence cash relief to those most affected by COVID-19.

4 Apr 2022

Smart toilets for passive surveillance of SARS-CoV-2

In a recent study published in Nature Digital Medicine, researchers highlighted a potential strategy for using a smart toilet platform, Coronavirus: Integrated Diagnostic (COV-ID), for passive monitoring of coronavirus disease 2019 (COVID-19).

3 Apr 2022

Natural compound found in cardamom shows promise for treating triple-negative breast cancer

Cardamonin - a natural compound found in the spice cardamom and other plants - could have therapeutic potential for triple-negative breast cancer, according to a new study using human cancer cells.

3 Apr 2022

Research demonstrates potential of local siRNA delivery as COVID antiviral therapy in the lung

Scientists develop a formulation for the pulmonary administration of siRNA. The aim was to suppress the replication of SARS-CoV-2.

3 Apr 2022

An in-depth analysis of pathogenesis of SARS-CoV-2 and therapeutic options for COVID-19

Scientists discuss the pathogenic characteristics of SARS-CoV-2 and available therapeutic interventions for treating COVID-19.

3 Apr 2022

Eating prunes every day may reduce pro-inflammatory mediators in postmenopausal women

A study in postmenopausal people suggests eating nutrient-rich prunes every day may be beneficial to bone health, reducing inflammatory factors that contribute to osteoporosis.

2 Apr 2022

Analysis of antioxidants, stress markers in the blood could lead to new diagnostic tool for breast cancer

A new study that analyzes levels of antioxidants and stress markers in the blood could lead to a new diagnostic tool for breast cancer. The research will be presented this week in Philadelphia at the American Physiological Society's annual meeting at Experimental Biology 2022.

2 Apr 2022

Phenolic extract from wild blueberries may improve wound healing

Treating wounds with an extract taken from wild blueberries may improve healing, according to a new study.

2 Apr 2022

Scientists use new CRISPR gene-editing approach to find paths toward possible HIV cure

Scientists at Northwestern Medicine are using new advances in CRISPR gene-editing technology to uncover new biology that could lead to longer-lasting treatments and new therapeutic strategies for Human Immunodeficiency Virus (HIV).

1 Apr 2022

Research illuminates why immune disorders affect only one of two identical twins

Scientists have long queried the causes of immune disorders in only one of two identical twins with identical genes. New research from the Wellcome Sanger Institute, the Josep Carreras Leukaemia Research Institute in Spain and their collaborators, has found the answer lies in both alterations in immune cell-cell communication and the epigenome, the host of biological processes that regulate how our genes function.

1 Apr 2022

Researchers explore a novel method to isolate monoclonal antibodies from COVID-19 convalescents infected with SARS-CoV-2 variants

Researchers developed a novel high-throughput method to obtain monoclonal antibodies from COVID-19 individuals infected with SARS-CoV-2 ancestral strain Wuhan-Hu-1 and the Beta or Gamma variants.

1 Apr 2022

Study finds COVID-19 convalescent children had more robust humoral immune responses to SARS-CoV-2 than convalescent adults

The work investigated why the children experienced milder COVID-19 illness even after a strong immune response.

1 Apr 2022

Study explores molecular mechanisms underlying SARS-CoV-2 infection of macrophages and the induction of pro-inflammatory cytokines

Researchers examined the role of sialic acid-binding immunoglobulin-type lectins-1, a myeloid cell-specific receptor, in facilitating SARS-CoV-2 infection of ACE2-deficient macrophages and its effect on pro-inflammatory cytokine expression.

1 Apr 2022

Study identifies a new class of monoclonal antibodies that neutralize both alpha and beta coronaviruses

A team of international scientists has recently isolated and characterized pan-coronavirus neutralizing antibodies from individuals with pre-existing immunity against SARS-CoV-2.

1 Apr 2022

Cell News and Research

The SAVE initiative to monitor the impact of SARS-CoV-2 variants

Key protein could be a novel target for treatment of patients with B cell signaling deficiencies

Study investigates targeted phenotyping of host proteins aiding drug repurposing in COVID-19

The effects of SARS-CoV-2 infection in different ancestry origins from the same region

Evidence SARS-CoV-2 undergoes ADAR-mediated A-to-I RNA editing in human cells

mRNA-1273 and BNT162b2 COVID-19 vaccines induce slightly different immune responses

AI helps identify areas in need of emergency aid

Smart toilets for passive surveillance of SARS-CoV-2

Natural compound found in cardamom shows promise for treating triple-negative breast cancer

Research demonstrates potential of local siRNA delivery as COVID antiviral therapy in the lung

An in-depth analysis of pathogenesis of SARS-CoV-2 and therapeutic options for COVID-19

Eating prunes every day may reduce pro-inflammatory mediators in postmenopausal women

Analysis of antioxidants, stress markers in the blood could lead to new diagnostic tool for breast cancer

Phenolic extract from wild blueberries may improve wound healing

Scientists use new CRISPR gene-editing approach to find paths toward possible HIV cure

Research illuminates why immune disorders affect only one of two identical twins

Researchers explore a novel method to isolate monoclonal antibodies from COVID-19 convalescents infected with SARS-CoV-2 variants

Study finds COVID-19 convalescent children had more robust humoral immune responses to SARS-CoV-2 than convalescent adults

Study explores molecular mechanisms underlying SARS-CoV-2 infection of macrophages and the induction of pro-inflammatory cytokines

Study identifies a new class of monoclonal antibodies that neutralize both alpha and beta coronaviruses

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