Genes News and Research

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Penn Medicine announces $375,000 in new grants to support BRCA-focused research projects

Penn Medicine's Basser Center for BRCA announced $375,000 in new grant funding to support BRCA-focused research projects across the nation. The grants are aimed at advancing the care of patients living with BRCA1 and BRCA2 mutations.

7 Oct 2015

Researchers describe unknown mechanism behind progeria

Progeria, a premature aging disease, is the research focus of Roland Foisner's team at the Max F. Perutz Laboratories of the University of Vienna and the Medical University of Vienna. Children suffering from progeria die at an average age of 14 to 15 years, often from heart attacks and strokes.

7 Oct 2015

New studies suggest ways to improve cancer care by inhibiting oncogenes, boosting tumor-suppressor activity

Two new studies by cancer scientists at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC - James) suggest new approaches for treating cancer by inhibiting overactive cancer-promoting genes and by enhancing the activity of sluggish tumor-suppressor genes.

7 Oct 2015

Cervicovaginal mucus effectively traps HIV particles

HIV particles are effectively trapped by the cervicovaginal mucus from women who harbor a particular vaginal bacteria species, Lactobacillus crispatus. The findings, published this week in mBio, an online open-access journal of the American Society for Microbiology, could lead to new ways to reduce or block vaginal transmission of HIV and other sexually transmitted infections (STIs).

7 Oct 2015

Quest Diagnostics provides PD-L1 IHC 22C3 PharmDx test service for NSCLC patients

Quest Diagnostics, the world’s leading provider of diagnostic information services, today announced that it will provide clinical laboratory testing using the PD-L1 IHC 22C3 PharmDx immunohistochemistry companion diagnostic.

From Quest Diagnostics 7 Oct 2015

Study describes new genome screen that identifies partner molecules of cell-waste disposal proteins

Rhythmic expression of key genes is essential for maintaining proper timekeeping of the body's clock. In addition, rhythmic degradation of clockwork proteins is also crucial. However, surprisingly, researchers know little about these specific processes.

7 Oct 2015

Jumping genes: a marker for early cancer diagnosis? An interview with Dr Kazazian

In the genome of every human being, there are about 80-100 active LINE-1s that are capable of mobilizing by a copy and paste mechanism to a new location in the genome.

6 Oct 2015

Genetic carrier screening: an interview with Don Hardison, CEO of Good Start Genetics

Carrier screening provides you and your doctor with information about your risks of having a child with a serious genetic disease prior to or during pregnancy.

6 Oct 2015

NIH-funded researchers test new gene therapy to improve visual function in mice

Researchers funded by the National Institutes of Health have developed a novel mouse model for the vision disorder Leber hereditary optic neuropathy (LHON), and found that they can use gene therapy to improve visual function in the mice. LHON is one of many diseases tied to gene mutations that damage the tiny energy factories that power our cells, called mitochondria.

6 Oct 2015

Novel computational strategy may help identify genetic variants that cause disease in children

The team behind the Deciphering Developmental Disorders (DDD) Study, one of the world's largest nationwide rare disease genome-wide sequencing initiatives, have developed a novel computational approach to identify genetic variants that cause disease in young children.

6 Oct 2015

Paradigm failure is primary reason for lack of progress in cancer research, says cancer biologist

A recent publication, which received sustained media attention, claimed that most cancers are just “bad luck”. Its authors stated that only about one-third of cancer mutations are caused by known lifestyle or environmental factors.

6 Oct 2015

Quitting smoking may delay secondary progressive MS onset

Patients who are smokers when diagnosed with relapsing–remitting multiple sclerosis may be able to delay the time to onset of progressive disease by quitting smoking, a study suggests.

1 Oct 2015

Early genetic diagnosis in neonatal diabetes a ‘new framework for clinical care’

Early genetic testing of babies with suspected neonatal diabetes identifies the underlying cause in more than 80% of cases, say researchers.

1 Oct 2015

International team of scientists create world's largest catalog of genomic variations among humans

An international team of scientists from the 1000 Genomes Project Consortium has created the world's largest catalog of genomic differences among humans, providing researchers with powerful clues to help them establish why some people are susceptible to various diseases. While most differences in peoples' genomes - called variants - are harmless, some are beneficial, while others contribute to diseases and conditions, ranging from cognitive disabilities to susceptibilities to cancer, obesity, diabetes, heart disease and other disorders.

1 Oct 2015

Two studies identify promising new anti-retroviral strategy to combat HIV-1

A pair of studies by researchers at the University of Massachusetts Medical School, the University of Trento in Italy, and the University of Geneva in Switzerland, point to a promising new anti-retroviral strategy for combating HIV-1.

1 Oct 2015

Researchers identify new gene locus that may protect children from developing malaria in Africa

Published today in Nature, the findings detail a new gene locus that can explain why, in communities where everyone is constantly exposed to malaria, some children develop severe malaria and others don't. Now, researchers can be sure that this particular stretch of our DNA plays a crucial role in the progression of the disease.

1 Oct 2015

Genes News and Research

Penn Medicine announces $375,000 in new grants to support BRCA-focused research projects

Researchers describe unknown mechanism behind progeria

New studies suggest ways to improve cancer care by inhibiting oncogenes, boosting tumor-suppressor activity

Cervicovaginal mucus effectively traps HIV particles

Quest Diagnostics provides PD-L1 IHC 22C3 PharmDx test service for NSCLC patients

Study describes new genome screen that identifies partner molecules of cell-waste disposal proteins

Jumping genes: a marker for early cancer diagnosis? An interview with Dr Kazazian

Genetic carrier screening: an interview with Don Hardison, CEO of Good Start Genetics

NIH-funded researchers test new gene therapy to improve visual function in mice

Novel computational strategy may help identify genetic variants that cause disease in children

Paradigm failure is primary reason for lack of progress in cancer research, says cancer biologist

Quitting smoking may delay secondary progressive MS onset

Early genetic diagnosis in neonatal diabetes a ‘new framework for clinical care’

International team of scientists create world's largest catalog of genomic variations among humans

Two studies identify promising new anti-retroviral strategy to combat HIV-1

Researchers identify new gene locus that may protect children from developing malaria in Africa

Researchers discover five new genetic variants associated with brain cancer

New research sheds light on how retina sets its own biological rhythm using neuropsin

Research shows why microgravity leads to muscle loss

Study suggests link between human endogenous retroviral genes and ALS

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