Genes News and Research

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New reference catalogue may help guide future studies of genetics, evolution and disease

Missing a gene may be less problematic than you'd think. This is one of the conclusions that emerge from the most extensive catalogue of structural variations - changes in large sections of a person's DNA sequence - to date.

1 Oct 2015

UH researcher investigates two new avenues for detection, treatment of prostate cancer

Prostate cancer is the most commonly diagnosed malignancy and second leading cause of cancer-related deaths among men in the U.S. The challenge with prostate cancer is that the standard treatment methods in the advanced stage of the disease lose effectiveness after about one to two years, leading to recurrence and, ultimately, death. A University of Houston researcher and his team are working to change that.

30 Sep 2015

Unlocking the genes behind antibiotic resistance: an interview with Professor Romesberg

Bacteria are very, very diverse. This is why their susceptibility to different antibiotics can be very different. It also makes the tools they have to evolve resistance in many cases different.

30 Sep 2015

Researchers reveal how varied genetic background influences tumour differences

Researchers from Uppsala University, Sweden, and the Broad Institute, USA, have identified both similarities and differences between a single tumour type in multiple dogs breeds; a finding they believe parallels the situation in the cancer of human patients.

30 Sep 2015

Leading cancer researchers address eight 'big questions'

Leading cancer researchers address eight of the "big questions" facing the field as part of the inaugural issue of Trends in Cancer, published by Cell Press.

30 Sep 2015

New test identifies viruses that infect people and animals

A new test detects virtually any virus that infects people and animals, according to research at Washington University School of Medicine in St. Louis, where the technology was developed.

30 Sep 2015

Intratumoral morphological diversity of breast cancer not related to chromosome aberrations

Intratumor morphological heterogeneity (diversity) of breast cancer is not related to chromosome aberrations. This conclusion was made based on the study of one case with aggressive variant of breast cancer - invasive micropapillary carcinoma by researchers from Tomsk State University, Tomsk Cancer Research Institute, and Institute of Medical Genetics.

30 Sep 2015

New report implicates five genetic regions that play major roles in CF disease severity

If you have two faulty copies of the CFTR gene, you will have cystic fibrosis. But the severity of your disease will depend on environmental factors and many other genes. Locating these genes and altering their function could lead to new therapies.

29 Sep 2015

Study: Increased acetylation of histones promotes fear extinction in mice

The targeted modulation of gene activity and cellular signaling pathways could provide a new approach to the treatment of fear and anxiety states according to the recent findings of a project sponsored by the Austrian Science Fund FWF.

29 Sep 2015

Low birth weight associated with low levels of social trust in adulthood

How much does your baby weigh? All new parents are familiar with that question. Perhaps their reply is more important than we realize. Birth weight affects how much trust an individual will have in other people in his adult life. Trust, in turn, is the glue that prevents society from falling apart. This phenomenon is at the center of new research from Aarhus School of Business and Social Sciences (Aarhus BSS) at Aarhus University, Denmark.

29 Sep 2015

New single-molecule tool may help detect interactions between DNA and enzymatic proteins

A team of scientists at the University of Washington and the biotechnology company Illumina have created an innovative tool to directly detect the delicate, single-molecule interactions between DNA and enzymatic proteins.

29 Sep 2015

UT Southwestern Medical Center geneticist named 2015 recipient of Pearl Meister Greengard Prize

UT Southwestern Medical Center geneticist Dr. Helen Hobbs is the 2015 recipient of the prestigious Pearl Meister Greengard Prize. The prize recognizes Dr. Hobbs' research, which advances understanding of heart disease and other complex disorders.

29 Sep 2015

Increasing availability of genetic tests for at-risk cancer patients

Mutations in the BRCA 1 and BRCA 2 genes are very likely to lead to a form of cancer in people who have them. These mutations can be detected using a genetic test. The introduction of a new drug has improved treatment options and this, coupled with increased awareness and improved access, increased the number of genetic tests carried out at the MedUni Vienna last year by a factor of five.

28 Sep 2015

Multigene test performed on tumor can identify breast cancer patients who can safely avoid chemotherapy

A major study published in the New England Journal of Medicine is providing the best evidence to date that a 21-gene test done on the tumor can identify breast cancer patients who can safely avoid chemotherapy.

28 Sep 2015

Genetic mutations predict breast cancer relapse

A large genetics study has identified genetic mutations specific to recurrent breast cancer cells. Screening for these mutations in breast cancer tumours could therefore allow doctors to identify patients most at risk of their cancer returning. The relevant genes can then be targeted to prevent recurrence of the cancer.

27 Sep 2015

Researchers find mutated gene responsible for cardiac angiosarcoma in two brothers

A few years ago, Javier Benítez, director of the Human Genetics Group at the CNIO, received a call from Pablo García Pavía, from the Cardiology Unit of the Puerta de Hierro University Hospital. This cardiologist was treating two brothers with a rare form of cancer, cardiac angiosarcoma (CAS).

26 Sep 2015

Researchers develop methodology to monitor changes in DNA methylation patterns in individual cells

Whitehead Institute researchers have developed a methodology to monitor changes in DNA methylation over time in individual cells.

26 Sep 2015

CHOP scientist says that mitochondria play central role in human evolution, disease

Mitochondria are not only the power plants of our cells, these tiny structures also play a central role in our physiology. Furthermore, by enabling flexible physiological responses to new environments, mitochondria have helped humans and other mammals to adapt and evolve throughout the history of life on earth.

26 Sep 2015

New study on deep-diving whales may help researchers create synthetic blood for human trauma patients

The ultra-stable properties of the proteins that allow deep-diving whales to remain active while holding their breath for up to two hours could help Rice University biochemist John Olson and his colleagues finish a 20-year quest to create lifesaving synthetic blood for human trauma patients.

26 Sep 2015

Scientists compile complete genetic information of people affected by PAH

The genetic architecture of a debilitating and potentially fatal vascular disease has for the first time been detailed in its entirety, providing clinicians with the comprehensive data needed to improve diagnosis and deliver more personalised patient care.

25 Sep 2015

Genes News and Research

New reference catalogue may help guide future studies of genetics, evolution and disease

UH researcher investigates two new avenues for detection, treatment of prostate cancer

Unlocking the genes behind antibiotic resistance: an interview with Professor Romesberg

Researchers reveal how varied genetic background influences tumour differences

Leading cancer researchers address eight 'big questions'

New test identifies viruses that infect people and animals

Intratumoral morphological diversity of breast cancer not related to chromosome aberrations

New report implicates five genetic regions that play major roles in CF disease severity

Study: Increased acetylation of histones promotes fear extinction in mice

Low birth weight associated with low levels of social trust in adulthood

New single-molecule tool may help detect interactions between DNA and enzymatic proteins

UT Southwestern Medical Center geneticist named 2015 recipient of Pearl Meister Greengard Prize

Increasing availability of genetic tests for at-risk cancer patients

Multigene test performed on tumor can identify breast cancer patients who can safely avoid chemotherapy

Genetic mutations predict breast cancer relapse

Researchers find mutated gene responsible for cardiac angiosarcoma in two brothers

Researchers develop methodology to monitor changes in DNA methylation patterns in individual cells

CHOP scientist says that mitochondria play central role in human evolution, disease

New study on deep-diving whales may help researchers create synthetic blood for human trauma patients

Scientists compile complete genetic information of people affected by PAH

eBook: Using iPSCs models for human disease research and drug discovery eBook

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Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics