Clinical Trial News and Research

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AI-powered therapy chatbot shows significant mental health benefits

Dartmouth researchers conducted the first clinical trial of a therapy chatbot powered by generative AI and found that the software resulted in significant improvements in participants' symptoms, according to results published March 27 in the New England Journal of Medicine AI.

27 Mar 2025

Study identifies PDGFRA as a potential target for pediatric high-grade gliomas

Pediatric high-grade gliomas, particularly H3K27M diffuse midline gliomas (DMG), are aggressive malignant brain tumors with a poor prognosis.

26 Mar 2025

Oklahoma researcher uses technology to combat alcohol use disorder in primary care

According to the Centers for Disease Control and Prevention, 1 in 7 adults in the United States will experience a substance use disorder during their lifetime. University of Oklahoma College of Medicine faculty member Brandi Fink, Ph.D., is working with primary care clinics and health care systems to identify people with an alcohol use disorder and intervene early before the problem worsens.

25 Mar 2025

Women with premenstrual syndrome appear to find relief from symptoms with placebos

Women affected by premenstrual syndrome (PMS) appear to experience less intense and debilitating symptoms after taking placebo pills even when told they do not contain any active medication, suggests a study published in the open-access journal BMJ Evidence-Based Medicine.

25 Mar 2025

New trial aims to make rectal cancer more responsive to radiation

City of Hope, one of the largest and most advanced cancer research and treatment organizations in the U.S. with its National Medical Center named top 5 in the nation for cancer by U.S. News & World Report, has opened a phase 1 trial seeking to one day transform rectal cancer from a mostly radiation-resistant disease to one that can be cured using radiation and chemotherapy.

25 Mar 2025

Scientists develop universal vaccine targeting multiple coronaviruses

Sugar coatings aren't only for candies; they also help viruses, like the ones that cause COVID-19, hide from their hosts' immune system.

25 Mar 2025

Study shows artificial intelligence can improve intravenous nutrition for premature babies

Artificial intelligence can improve intravenous nutrition for premature babies, a Stanford Medicine study has shown.

25 Mar 2025

Besifovir dipivoxil maleate offers comparable efficacy and improved safety for hepatitis B patients

Hepatitis B is a liver infection cause by the hepatitis B virus (HBV), and long-term hepatitis B infections that last longer than six months are considered "chronic".

24 Mar 2025

A pecan a day keeps bad cholesterol away

Daily consumption of 57g of pecans for 12 weeks improved cholesterol profiles and diet quality in adults at risk of cardiometabolic disease, without affecting vascular health. Replacing typical snacks with pecans led to higher intake of healthy fats and fiber, and reduced carbohydrate consumption.

24 Mar 2025

Researchers develop tool to enhance NK cells against cancer

A team of researchers from the Hospital del Mar Research Institute, the Universitat Autònoma de Barcelona and the Pompeu Fabra University has developed a new tool that allows modifying these NK cells to make them immune to the tumor’s defense mechanism.

24 Mar 2025

New technique doubles erectile function preservation in prostate surgery

A technique to improve the precision of prostate cancer surgery means that almost twice as many men preserve their erectile function compared to those undergoing standard surgery, according to results from a clinical trial led by researchers from UCL and UCLH.

24 Mar 2025

Micro-ultrasound proves as effective as MRI in prostate cancer diagnosis

Biopsies guided by high resolution ultrasound are as effective as those using MRI in diagnosing prostate cancer, an international clinical trial has shown.

24 Mar 2025

Women with urinary incontinence can avoid invasive bladder pressure tests

Women with ongoing urinary incontinence could avoid invasive bladder pressure tests, as new research shows that a range of non-invasive assessments work just as well in guiding treatment.

22 Mar 2025

Concierge approach enables more people to receive kidney transplants and erases disparities

Patients hoping for a kidney transplant must first undergo a battery of medical tests to determine whether they are suitable candidates for the procedure and healthy enough to take post-transplant immunosuppressant drugs to prevent organ rejection.

22 Mar 2025

Cleveland Clinic study reveals insights on immune checkpoint inhibitors for colorectal cancer

A team of researchers from Cleveland Clinic Genomic Medicine share insights from an early set of 19,000 patients to receive immune checkpoint inhibitor treatments for colorectal cancer in the U.S.

20 Mar 2025

Avoiding prostate cancer screening increases risk of death

Men who consistently avoid prostate cancer screening appointments face a disproportionately higher risk of dying from the disease, finds research identifying a new high-risk group.

20 Mar 2025

Deep brain stimulation shows promise for reducing self-injurious behavior in children with autism

Severe self-injurious behavior in children with autism spectrum disorder (ASD) poses a significant risk of permanent physical injury.

20 Mar 2025

New targeted therapy shows early success in treating pediatric high-grade gliomas

An international team of clinical collaborators, led by physician scientists from Dana-Farber Cancer Institute, performed a first-ever clinical test of the targeted therapy avapritinib in pediatric and young patients with a form of high-grade glioma.

20 Mar 2025

Experimental drug shows promise in reducing risk of Alzheimer's-related dementia

An experimental drug appears to reduce the risk of Alzheimer's-related dementia in people destined to develop the disease in their 30s, 40s or 50s, according to the results of a study led by the Knight Family Dominantly Inherited Alzheimer Network-Trials Unit (DIAN-TU), which is based at Washington University School of Medicine in St. Louis.

19 Mar 2025

Clinical trial investigates osteoporosis medication for type 1 diabetes

City of Hope®, one of the largest and most advanced cancer research and treatment organizations in the United States and a top research center for diabetes and other life-threatening illnesses, is leading a phase 1/2 clinical trial investigating an osteoporosis medication as a way to improve beta cell health in people with early type 1 diabetes.

19 Mar 2025

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Clinical Trial News and Research

AI-powered therapy chatbot shows significant mental health benefits

Study identifies PDGFRA as a potential target for pediatric high-grade gliomas

Oklahoma researcher uses technology to combat alcohol use disorder in primary care

Women with premenstrual syndrome appear to find relief from symptoms with placebos

New trial aims to make rectal cancer more responsive to radiation

Scientists develop universal vaccine targeting multiple coronaviruses

Study shows artificial intelligence can improve intravenous nutrition for premature babies

Besifovir dipivoxil maleate offers comparable efficacy and improved safety for hepatitis B patients

A pecan a day keeps bad cholesterol away

Researchers develop tool to enhance NK cells against cancer

New technique doubles erectile function preservation in prostate surgery

Micro-ultrasound proves as effective as MRI in prostate cancer diagnosis

Women with urinary incontinence can avoid invasive bladder pressure tests

Concierge approach enables more people to receive kidney transplants and erases disparities

Cleveland Clinic study reveals insights on immune checkpoint inhibitors for colorectal cancer

Avoiding prostate cancer screening increases risk of death

Deep brain stimulation shows promise for reducing self-injurious behavior in children with autism

New targeted therapy shows early success in treating pediatric high-grade gliomas

Experimental drug shows promise in reducing risk of Alzheimer's-related dementia

Clinical trial investigates osteoporosis medication for type 1 diabetes

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