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KAIST scientists predict how biological circuits sustain rhythms

Our bodies have a variety of biological clocks that follow rhythms or oscillations with periods ranging from seconds to days. For example, our hearts beat every second, and cells divide periodically. The circadian clock located in the hypothalamus generates twenty-four hour rhythms, timing our sleep and hormone release.

29 Aug 2015

Researchers provide new insights into biology of aging, age-related diseases

The scientific team of a new biotech company Gero in collaboration with one of the leading academics in the field of aging Prof. Robert J. Shmookler Reis (current world record holder in life extension for model animals - 10 fold for nematodes) has recently brought new insights into biology of aging and age-related diseases, primarily, around the stability and stress resistance of certain gene regulatory networks.

28 Aug 2015

Findings reveal a new way to prevent meningitis

The fungus Cryptococcus causes meningitis, a brain disease that kills about 1 million people each year — mainly those with impaired immune systems due to AIDS, cancer treatment or an organ transplant.

28 Aug 2015

Researchers find fatty acid deposits in brains of Alzheimer's patients

People with Alzheimer's disease have fat deposits in the brain. For the first time since the disease was described 109 years ago, researchers affiliated with the University of Montreal Hospital Research Centre (CRCHUM) have discovered accumulations of fat droplets in the brain of patients who died from the disease and have identified the nature of the fat.

28 Aug 2015

Adaptive immune system plays active role in guiding development of mammary glands

In experiments with mouse tissue, UC San Francisco researchers have discovered that the adaptive immune system, generally associated with fighting bacterial and viral infections, plays an active role in guiding the normal development of mammary glands, the only organs--in female humans as well as mice--that develop predominately after birth, beginning at puberty.

28 Aug 2015

New review article reveals Y chromosome’s role in cardiovascular and immune function, cancer

The role of sex in human disease is a growing area of research. Although estrogen (in females) and androgens (in males) are often seen as possible causes for such differences, sex chromosomes, including the male-specific Y chromosome, may also play a role. However, it has been difficult to understand how the Y chromosome could contribute to disease in men, in part because it is much more difficult to sequence than all other chromosomes.

28 Aug 2015

Melatonin hormone can help prevent cardiovascular disease risk in children born through ART

Studies are revealing that children born through assisted reproductive technologies (ART) have a higher risk of developing cardiovascular disease. The increased risk is due to changes in the expression of the genes important for vascular health. These studies suggest that the composition of the solutions in which embryo fertilization and culturing are done is to blame.

28 Aug 2015

Researchers identify new virus that plays role in rare type of liver cancer

More than a cause of a simple infection, viruses are often involved in the development of serious diseases. Such is the case with liver cancer, which often develops in an organ that has been weakened by hepatitis B or C virus.

28 Aug 2015

Researchers find way to trigger 'virus alert' that may help boost drug's ability to prevent cancer cells

Working with human cancer cell lines and mice, researchers at the Johns Hopkins Kimmel Cancer Center and elsewhere have found a way to trigger a type of immune system "virus alert" that may one day boost cancer patients' response to immunotherapy drugs. An increasingly promising focus of cancer research, the drugs are designed to disarm cancer cells' ability to avoid detection and destruction by the immune system.

27 Aug 2015

Discovery could help in development of novel cancer-selective viral therapies

Every organism--from a seedling to a president--must protect its DNA at all costs, but precisely how a cell distinguishes between damage to its own DNA and the foreign DNA of an invading virus has remained a mystery.

27 Aug 2015

NTNU researchers find link between aggression and gene variant in children

Some children react more strongly to negative experiences than others. Researchers from the Norwegian University of Science and Technology have found a link between aggression and variants of a particular gene.

27 Aug 2015

New study describes multi-method strategy to improve detection of PMS2 gene mutations in Lynch syndrome

About 3% of colorectal cancers are due to Lynch syndrome, an inherited cancer susceptibility syndrome that predisposes individuals to various cancers. Close blood relatives of patients with Lynch syndrome have a 50% chance of inheritance. The role that PMS2 genetic mutations play in Lynch syndrome has been underestimated in part due to technological limitations.

27 Aug 2015

Researchers design online database to help researchers identify cancer gene mutations

Many clinical trials use genome sequencing to learn which gene mutations are present in a patient's tumor cells. The question is important because targeting the right mutations with the right drugs can stop cancer in its tracks. But it can be difficult to determine whether there is evidence in the medical literature that particular mutations might drive cancer growth and could be targeted by therapy, and which mutations are of no consequence.

27 Aug 2015

Two studies highlight important new discovery around most common genetic defect linked to ALS

In today's issue of Nature, two new studies funded in part by The ALS Association both highlight an important new discovery around the C9orf72 mutation, the most common genetic defect associated with amyotrophic lateral sclerosis (ALS).

27 Aug 2015

UCSF study reveals molecular timing mechanism of stem cells

UC San Francisco researchers have for the first time developed a method to precisely control embryonic stem cell differentiation with beams of light, enabling them to be transformed into neurons in response to a precise external cue.

27 Aug 2015

Scientists reveal how a common gene mutation in ALS and FTD disrupts normal cell function

Researchers have determined how the most common gene mutation in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) disrupts normal cell function, providing insight likely to advance efforts to develop targeted therapies for these brain diseases.

27 Aug 2015

Variations in opioid receptor genes linked to neonatal abstinence syndrome severity in newborn babies

A new study led by researchers at Boston Medical Center indicates that variations in opioid receptor genes are associated with more severe neonatal abstinence syndrome (NAS) in newborn babies. The findings, published online in Drug & Alcohol Dependence, could help lead to the development of individualized treatment plans tailored to each infants' risk of requiring medication to curb their NAS symptoms, which could help improve these patients' outcomes and reduce how long some stay in the hospital.

26 Aug 2015

Study of genetic risk factors of IBD in African-Americans published in Gastroenterology journal

Researchers at the Johns Hopkins University School of Medicine, along with colleagues at Emory University and Cedars-Sinai, have published in the journal Gastroenterology the first major, in-depth analysis of genetic risk factors of inflammatory bowel disease in African-Americans.

26 Aug 2015

Moffitt researchers discover high BRCA mutation frequency in young black women with breast cancer

Women who have inherited mutations in the BRCA1 or BRCA2 genes are more likely to develop breast cancer or ovarian cancer, especially at a younger age. Approximately 5 percent of women with breast cancer in the United States have mutations in BRCA1 or BRCA2 based on estimates in non-Hispanic white women.

26 Aug 2015

Sequenom, UC San Diego Moores Cancer Center collaborate to explore utility of liquid biopsy assay

Sequenom, Inc., a life sciences company committed to enabling healthier lives through the development of innovative products and services, today announced that it has entered into a clinical research collaboration with the University of California, San Diego Moores Cancer Center.

26 Aug 2015

Genes News and Research

KAIST scientists predict how biological circuits sustain rhythms

Researchers provide new insights into biology of aging, age-related diseases

Findings reveal a new way to prevent meningitis

Researchers find fatty acid deposits in brains of Alzheimer's patients

Adaptive immune system plays active role in guiding development of mammary glands

New review article reveals Y chromosome’s role in cardiovascular and immune function, cancer

Melatonin hormone can help prevent cardiovascular disease risk in children born through ART

Researchers identify new virus that plays role in rare type of liver cancer

Researchers find way to trigger 'virus alert' that may help boost drug's ability to prevent cancer cells

Discovery could help in development of novel cancer-selective viral therapies

NTNU researchers find link between aggression and gene variant in children

New study describes multi-method strategy to improve detection of PMS2 gene mutations in Lynch syndrome

Researchers design online database to help researchers identify cancer gene mutations

Two studies highlight important new discovery around most common genetic defect linked to ALS

UCSF study reveals molecular timing mechanism of stem cells

Scientists reveal how a common gene mutation in ALS and FTD disrupts normal cell function

Variations in opioid receptor genes linked to neonatal abstinence syndrome severity in newborn babies

Study of genetic risk factors of IBD in African-Americans published in Gastroenterology journal

Moffitt researchers discover high BRCA mutation frequency in young black women with breast cancer

Sequenom, UC San Diego Moores Cancer Center collaborate to explore utility of liquid biopsy assay

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