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Lexicon Pharmaceuticals' revenues decrease to $0.4 million in second quarter 2015

Lexicon Pharmaceuticals, Inc., today reported financial results for the second quarter ended June 30, 2015 and provided an overview of key milestones for the company's lead drug candidates.

7 Aug 2015

Study: Dietary carbohydrate essential for evolution of modern big-brained humans

Understanding how and why we evolved such large brains is one of the most puzzling issues in the study of human evolution. It is widely accepted that brain size increase is partly linked to changes in diet over the last 3 million years, and increases in meat consumption and the development of cooking have received particular attention from the scientific community.

7 Aug 2015

Researchers identify genome-organizing mechanism that transmits vital genetic materials during mitosis

Chromosomes are responsible for carrying our genes and essentially protecting the information that helps ensure normal, healthy growth, with vital instructions being passed on from cell to cell by a process known as mitosis. While this copying mechanism has been well understood for decades, scientists have been unable to describe exactly how genetic information is protected and properly segregated as mitosis is happening.

7 Aug 2015

UNC researchers show how a genetic mutation disables molecular switch and causes autism

Last December, researchers identified more than 1,000 gene mutations in individuals with autism, but how these mutations increased risk for autism was unclear. Now, UNC School of Medicine researchers are the first to show how one of these mutations disables a molecular switch in one of these genes and causes autism.

7 Aug 2015

USC researchers develop yeast model to study gene mutation that disrupts DNA duplication

Researchers at USC have developed a yeast model to study a gene mutation that disrupts the duplication of DNA, causing massive damage to a cell's chromosomes, while somehow allowing the cell to continue dividing.

7 Aug 2015

New fly model developed to study motor neuron degeneration

Researchers at the Babraham Institute and University of Massachusetts Medical School in the United States have developed a new model to study motor neuron degeneration and have used this to identify three genes involved in the neurodegeneration process. These findings could have relevance for understanding the progression of amyotrophic lateral sclerosis (ALS) and other forms of motor neuron disease (MND).

7 Aug 2015

Researchers develop new technology to track DNA-protein binding in live cells

Researchers have developed a new technology that precisely marks where groups of regulatory proteins called transcription factors bind DNA in the nuclei of live cells.

7 Aug 2015

TSRI study shows antioxidants slow aging process, reduce risk of infection

Scientists from the Florida campus of The Scripps Research Institute have shown how aging cripples the production of new immune cells, decreasing the immune system’s response to vaccines and putting the elderly at risk of infection.

7 Aug 2015

WPI awarded NIH grant to explore ways to turn genetic tables against cancer

Taking aim at the fundamental biology of cancer cells, the National Institutes of Health has awarded $747,000 to Worcester Polytechnic Institute for a three-year research project to explore the molecular mechanisms associated with the genetic mutations and chromosome instability observed in all cancer cells.

7 Aug 2015

Lund University researchers discovered 'main switch' that regulates cell invaginations

Lack of microinvaginations in the cell membrane, caveolae, can cause serious diseases such as lipodystrophy and muscular dystrophy. Researchers at Lund University in Sweden have now discovered a "main switch" that regulates the formation of these invaginations.

7 Aug 2015

UC Davis study finds higher survival rates for women diagnosed with ovarian cancer

Combing data collected on thousands of California ovarian cancer patients, UC Davis researchers have determined that almost one-third survived at least 10 years after diagnosis.

7 Aug 2015

Results of IPC survey identifying 21 psoriasis research priorities published in British Journal of Dermatology

The British Journal of Dermatology has published online the results of an International Psoriasis Council (IPC) survey identifying 21 psoriasis research priorities. The results will also appear in a future print edition of the journal.

6 Aug 2015

Metformin drug has impact on blood fat levels

Besides affecting the blood sugar levels, the substance Metformin, also has an impact on blood fat levels. This was elucidated by an interdisciplinary team of the German Center for Diabetes Research headed by Dr. Rui Wang-Sattler of the Helmholtz Zentrum München. Especially the harmful LDL cholesterol can be reduced.

6 Aug 2015

Penn research reveals additional pathway for origin of colon cancer

Cancer researchers already know of some oncogenes and other factors that promote the development of colon cancers, but they don't yet have the full picture of how these cancers originate and spread. Now researchers from the Perelman School of Medicine at the University of Pennsylvania have illuminated another powerful factor in this process.

6 Aug 2015

Scientists use highly specialized X-ray crystallography technique to solve protein structure of HIFs

In a collaborative study between Sanford Burnham Prebys Medical Discovery Institute and the Argonne National Laboratory, scientists have used a highly specialized X-ray crystallography technique to solve the protein structure of hypoxia-inducible factors (HIFs), important regulators of a tumor's response to low oxygen (hyopoxia).

6 Aug 2015

Diets high in sodium could be a novel risk factor in development of multiple sclerosis

Here's another reason to put the salt shaker down: New research in mice shows that diets high in sodium may be a novel risk factor in the development of multiple sclerosis (MS) by influencing immune cells that cause the disease. Although this research does implicate salt intake as a risk factor, it is important to note that dietary salt is likely just one of the many environmental factors contributing to this complex disease, and very much influenced by one's genetic background.

6 Aug 2015

Certain genes exposed to harsh environmental factors can increase diabetes risk

Arsenic, which can be present in ground water, modifies an enzyme that alters the secretion of insulin in the pancreas. Physicians, usually, show type II diabetes as a consequence of an exaggerated food intake and lack of exercise; however, there are about 50 genes that cause changes in the DNA, known as polymorphisms, that when combined with harsh environmental factors are at increased risk of developing the disease, mentioned PhD Marta Ostrosky Wegman, director of the Institute for Biomedical Research the National University of Mexico (UNAM).

5 Aug 2015

Findings by Joslin scientists may lead to early detection, treatment of complications in type 1 diabetes

Joslin scientists have advanced understanding of how the cellular repair process is impaired in type 1 diabetes, which can cause cell death and lead to complications. The findings appear in the August issue of Cell Metabolism.

5 Aug 2015

CRI commits $29.3 million in new funds to accelerate development of cancer immunotherapies

The Cancer Research Institute, a nonprofit organization dedicated to fueling the discovery and development of immunotherapies for all forms of cancer, announced that it has committed more than $29.3 million in new funds to accelerate cancer immunology research and cancer immunotherapy clinical development in the United States, Australia, Canada, France, Sweden, Switzerland, and The Netherlands.

5 Aug 2015

University of Liverpool study finds that HIV can continue to grow in patients despite treatment

HIV can continue to grow in patients who are thought to be responding well to treatment, according to research by the University of Liverpool.

5 Aug 2015

Genes News and Research

Lexicon Pharmaceuticals' revenues decrease to $0.4 million in second quarter 2015

Study: Dietary carbohydrate essential for evolution of modern big-brained humans

Researchers identify genome-organizing mechanism that transmits vital genetic materials during mitosis

UNC researchers show how a genetic mutation disables molecular switch and causes autism

USC researchers develop yeast model to study gene mutation that disrupts DNA duplication

New fly model developed to study motor neuron degeneration

Researchers develop new technology to track DNA-protein binding in live cells

TSRI study shows antioxidants slow aging process, reduce risk of infection

WPI awarded NIH grant to explore ways to turn genetic tables against cancer

Lund University researchers discovered 'main switch' that regulates cell invaginations

UC Davis study finds higher survival rates for women diagnosed with ovarian cancer

Results of IPC survey identifying 21 psoriasis research priorities published in British Journal of Dermatology

Metformin drug has impact on blood fat levels

Penn research reveals additional pathway for origin of colon cancer

Scientists use highly specialized X-ray crystallography technique to solve protein structure of HIFs

Diets high in sodium could be a novel risk factor in development of multiple sclerosis

Certain genes exposed to harsh environmental factors can increase diabetes risk

Findings by Joslin scientists may lead to early detection, treatment of complications in type 1 diabetes

CRI commits $29.3 million in new funds to accelerate development of cancer immunotherapies

University of Liverpool study finds that HIV can continue to grow in patients despite treatment

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