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Researchers uncover new mechanism that p53 protein uses to trigger cell death

Researchers have identified a new mechanism that the tumor suppressor protein p53 uses to trigger cell death via apoptosis and have shown how the process could be harnessed to kill cancer cells. St. Jude Children's Research Hospital scientists led the study, which appears today in the scientific journal Molecular Cell.

31 Jul 2015

Female patients with depression have abnormally high expression levels of glutamate receptor genes

Numerous genes that regulate the activity of a neurotransmitter in the brain have been found to be abundant in brain tissue of depressed females. This could be an underlying cause of the higher incidence of suicide among women, according to research at the University of Illinois at Chicago.

31 Jul 2015

Researchers uncover master regulators that govern the fate of TFH cells

Follicular helper Tcells (TFH cells), a rare type of immune cell that is essential for inducing a strong and lasting antibody response to viruses and other microbes, have garnered intense interest in recent years but the molecular signals that drive their differentiation had remained unclear.

31 Jul 2015

Prostate cancer discovery may improve treatment strategies

Scientists from Cancer Research UK have discovered that there are five different types of prostate cancer and have found a way of distinguishing between them. These findings could change how the condition is treated, providing more effective therapies where they are needed the most.

30 Jul 2015

Novel 3D human skin tissue model could help detect presence of known skin sensitizers in medical device extracts

New research shows that exposing a 3D human skin tissue model to extracts of medical device materials can detect the presence of sensitizers known to cause an allergic response on contact in some individuals. Conventional skin sensitization testing of medical devices relies on animal testing, whereas human skin models could replace animal methods, according to an article in the new journal Applied In Vitro Toxicology, a peer-reviewed publication from Mary Ann Liebert, Inc., publishers.

30 Jul 2015

Detailed molecular analyses reveal new treatment options for aggressive childhood leukemia

Acute lymphoblastic leukemia (ALL) leukemia is the most common type of cancer in children. It can occur in various forms, differing not only by specific changes in the genetic material of the leukemia cells but also by their response to therapies. Now, an international team of scientists from Berlin, Düsseldorf, Hannover, Heidelberg, Kiel, and Zurich have succeeded in decoding the molecular characteristics of an as yet incurable subtype of leukemia, paving the way for new therapeutic approaches.

30 Jul 2015

Cancer Research UK scientists identify five distinct types of prostate cancer

Cancer Research UK scientists have for the first time identified that there are five distinct types of prostate cancer and found a way to distinguish between them, according to a landmark study published today in EBioMedicine.

30 Jul 2015

New study reports creation of genetic porcine model of cancer

With many types of cancers, early detection offers the best hope for survival. However, research into new early-detection screenings, as well as possible interventional radiology and surgical treatments, has been hindered by the lack of a large animal model that would accurately reflect the types of cancers seen in human cells.

30 Jul 2015

Study shows how genetic changes lead to differences in form and function of species

Ten thousand years ago, a golden grain got naked, brought people together and grew to become one of the top agricultural commodities on the planet.

30 Jul 2015

Scientists study role of protein oxidation in the ageing process

Research published in the journal Cell Reports challenges the most popular theory about why our bodies deteriorate in old age. Scientists know that as we grow older our cells accumulate particles, called free radicals.

30 Jul 2015

Blocking the expression of certain gene reduces excessive fat in patients

By blocking the expression of a certain gene in patients, University of Montreal researchers have contributed to the demonstration of great decreases in the concentration of triglycerides in their blood, even in various severe forms of hypertriglyceridemia and regardless of the base values or the treatment the patient usually receives.

30 Jul 2015

Low blood level of 4 proteins can help diabetics protect against immune attack

Patients with type 1 diabetes have significantly lower blood levels of four proteins that help protect their tissue from attack by their immune system, scientists report.

30 Jul 2015

Discovery could put individuals with relapsing UTIs on fast track for new therapeutic regimen

It's one thing to grow bacteria in a test tube, perform a screen in the lab, and find a mutation in the pathogen's genes. It's a whole other thing, and much rarer, to find the exact same mutation in nature--in this case, in E. coli in urine samples from some 500 patients suffering from relapsing urinary tract infections.

30 Jul 2015

Vismodegib therapy effective against medulloblastoma

A targeted therapy already used to treat advanced skin cancer is also effective against the most common subtype of the brain tumor medulloblastoma in adults and should be considered for treatment of newly diagnosed patients, according to research led by St. Jude Children's Research Hospital.

30 Jul 2015

Discovery paves way for new therapeutic approaches to treat fatal leukemia in children

Acute lymphoblastic leukemia (ALL) is the most common type of cancer in children. It can occur in various forms, differing not only by specific changes in the genetic material of the leukemia cells but also by their response to therapies.

30 Jul 2015

Cepheid announces international availability of updated Xpert Carba-R test to identify Superbugs

Cepheid today announced the international availability of an update to Xpert Carba-R, with the addition of two newly emerging carbapenemase genes, OXA-181 and OXA-232. The on-demand, molecular test also detects and differentiates among the five most prevalent mechanisms of carbapenem resistance, namely KPC, NDM, VIM, IMP-1 and OXA-48.

29 Jul 2015

Researchers explore impact of nutrients, probiotics before and during pregnancy on mothers and babies

Researchers in the United Kingdom (Southampton), Singapore and New Zealand (Auckland) from the EpiGen Global Research Consortium are to trial the use of a combination of nutrients and probiotics before and during pregnancy in a bid to improve the health of mothers and their babies.

29 Jul 2015

New type of mycovirus can cause aspergillosis in humans

Researchers, led by Dr Robert Coutts, Leverhulme Research Fellow from the School of Life and Medical Sciences at the University of Hertfordshire, and Dr Ioly Kotta-Loizou, Research Associate at Imperial College, have discovered a completely novel type of mycovirus.

29 Jul 2015

EUMODIC brings together scientists to study functions of 320 genes in mice

Since mice share 90 percent of our genes they play an important role in understanding human genetics. The European Mouse Disease Clinic brought together scientists from across Europe to investigate the functions of 320 genes in mice. Over half of these genes had no previously known role, and the remaining genes were poorly understood.

29 Jul 2015

Study findings could lead to new ways to tailor therapies for cancer

By studying the yeast used in beer- and bread-making, researchers at the University of Pittsburgh School of Medicine have uncovered the mechanism by which ancient proteins repair DNA damage and how their dysfunction could lead to the development of tumors.

28 Jul 2015

Genes News and Research

Researchers uncover new mechanism that p53 protein uses to trigger cell death

Female patients with depression have abnormally high expression levels of glutamate receptor genes

Researchers uncover master regulators that govern the fate of TFH cells

Prostate cancer discovery may improve treatment strategies

Novel 3D human skin tissue model could help detect presence of known skin sensitizers in medical device extracts

Detailed molecular analyses reveal new treatment options for aggressive childhood leukemia

Cancer Research UK scientists identify five distinct types of prostate cancer

New study reports creation of genetic porcine model of cancer

Study shows how genetic changes lead to differences in form and function of species

Scientists study role of protein oxidation in the ageing process

Blocking the expression of certain gene reduces excessive fat in patients

Low blood level of 4 proteins can help diabetics protect against immune attack

Discovery could put individuals with relapsing UTIs on fast track for new therapeutic regimen

Vismodegib therapy effective against medulloblastoma

Discovery paves way for new therapeutic approaches to treat fatal leukemia in children

Cepheid announces international availability of updated Xpert Carba-R test to identify Superbugs

Researchers explore impact of nutrients, probiotics before and during pregnancy on mothers and babies

New type of mycovirus can cause aspergillosis in humans

EUMODIC brings together scientists to study functions of 320 genes in mice

Study findings could lead to new ways to tailor therapies for cancer

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