Genes News and Research

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CQDM, OCE grant $1.5M to speed up drug discovery and development in Quebec-Ontario Life Sciences Corridor

CQDM and Ontario Centres of Excellence will fund five highly innovative and unconventional game-changing research and development projects to accelerate drug discovery in the Quebec-Ontario Life Sciences Corridor. Partners are granting $1.5M to Quebec-based and, for the first time, Ontario-based researchers thanks to the partnership with OCE through CQDM's 2014 Explore Program, one of CQDM's flagship programs focusing on early concept validation of cutting-edge technologies that address the most crucial needs in drug discovery and development.

17 Jun 2015

Study highlights discovery of genetic variants linked to mucinous ovarian carcinomas

New research by an international team including Keck Medicine of USC scientists is bringing the origins of ovarian cancer into sharper focus.

16 Jun 2015

Researchers uncover new mechanism that innate immune system uses to curb viral infections

An innovative mechanism that the innate immune system uses to control viral infections has been uncovered by researchers at the University Medical Centers in Mainz and Freiburg. Central to this is the discovery that two different but related elements of the immune system can act together in concert to fight, for example, rotavirus infections.

16 Jun 2015

Combination of tosedostat and LDAC results in overall response rate of 54% in elderly patients with AML

CTI BioPharma Corp. today announced findings from an investigator-sponsored Phase 2 trial in patients with either primary (de novo) acute myeloid leukemia (AML) or AML that has evolved from myelodysplastic syndrome (MDS). Results showed the combination of tosedostat with low dose cytarabine/Ara-C (LDAC) resulted in an overall response rate (ORR) of 54 percent in elderly patients with AML – with 45 percent of patients achieving durable complete responses (CR).

15 Jun 2015

Molecular classifications of low-grade gliomas proposed

Two research teams have independently proposed molecular classification systems for grade II and III glioma based on three tumour markers, with each category displaying distinct clinical features and outcomes.

12 Jun 2015

Scientists identify gene mutation linked to anaplastic oligodendroglioma

Scientists have identified a gene mutation linked to the development of an aggressive form of brain cancer. Researchers found that errors in a gene known as TCF12 - which plays a key role in the formation of the embryonic brain are associated with more aggressive forms of a disease called anaplastic oligodendroglioma.

12 Jun 2015

Researchers working on new system that can detect patient's antibiotic resistance in 30 minutes

A new device being developed by medical experts will transform the time it takes to detect antibiotic resistance in patients from several days to just half an hour.

12 Jun 2015

Researchers discover new aspect of gene regulation

Researchers at the Max F. Perutz Laboratories of the University of Vienna and the Medical University of Vienna as well as at the University of Natural Resources and Life Sciences in Vienna have discovered an entirely new aspect of gene regulation they call exitron splicing.

12 Jun 2015

Study seeks to determine environmental factors that protect against asthma, allergies

Researchers in the University of Arizona's BIO5 Institute have entered into a collaboration with Johnson & Johnson Consumer & Personal Products and Janssen Biotech Inc. to leverage foundational discovery research aimed at determining environmental factors that underlie asthma and allergies.

12 Jun 2015

Weill Cornell scientists reveal how XBP1 gene can trigger immune responses against ovarian tumors

Ovarian cancer shuts down immune system cells that would otherwise act as a first line of defense against the deadly tumor, Weill Cornell Medical College scientists report today. But a therapy that restores the cells' disease-fighting abilities could provide a powerful new strategy to attack the cancer, which kills more than 14,000 women each year.

12 Jun 2015

Certain ARID1a mutations sensitize some tumors to PARP inhibitor drugs

Mutations in ARID1a, which are common in many cancer types, disrupt DNA damage repair in cancer cells, allowing the cancer to progress. This gene may also be an Achilles' heel when treating certain tumors, according to a team of researchers at The University of Texas MD Anderson Cancer Center.

12 Jun 2015

New gene mutations in ADAMTS family may contribute to outcomes in ovarian cancer

There is the Addams Family. And then there is the ADAMTS family. While one is mindless entertainment, the latter may prove to be a new genetic avenue for designing ovarian cancer treatment.

11 Jun 2015

PGDx launches LungSelect product to identify genetic alterations in the plasma of NSCLC patients

Personal Genome Diagnostics, Inc., a provider of advanced cancer genome analysis and testing services, today announced the launch of its LungSelect product that identifies the most common, clinically actionable genetic alterations in the plasma of non-small cell lung cancer (NSCLC) patients.

11 Jun 2015

New insights on crop-rotation resistant rootworms may help develop sustainable agricultural practices

After decades of effort, scientists are finally figuring out how insects develop resistance to environmentally friendly farming practices - such as crop rotation - that are designed to kill them. The researchers say their insights will help develop more sustainable agricultural practices.

11 Jun 2015

Immune system linked to death of motor neurons in Amyotrophic lateral sclerosis

A previously unknown link between the immune system and the death of motor neurons in Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, has been discovered by scientists at the CHUM Research Centre and the University of Montreal. The finding paves the way to a whole new approach for finding a drug that can cure or at least slow the progression of such neurodegenerative diseases as ALS, Alzheimer's, Parkinson's and Huntington's diseases.

10 Jun 2015

Research reveals how a faulty gene can cause fatal abnormal heart rhythms during exercise

University of Manchester research presented today at the British Cardiovascular Society Conference has revealed how a faulty gene can cause fatal abnormal heart rhythms that are brought on by exercise.

10 Jun 2015

Researchers investigate how ingested nanoparticles may influence metabolic processes

Researchers at Binghamton University believe understanding nano particles' ability to influence our metabolic processing may be integral to mediating metabolic disorders and obesity, both of which are on the rise and have been linked to processed foods.

10 Jun 2015

New study shows that estrogen receptors vanish in cervical cancer tumors

Scientists have prior evidence that the hormone estrogen is a major driver in the growth of cervical cancer, but a new study examining genetic profiles of 128 clinical cases reached a surprising conclusion: Estrogen receptors all but vanish in cervical cancer tumors.

10 Jun 2015

Researchers examine specific causes of mortality after blood and marrow transplant

Blood and Marrow Transplantation (BMT) is a potentially curative treatment for patients with leukemia or other life-threating blood diseases. With a goal of increasing survival rates, a research team led by Roswell Park Cancer Institute investigators verified patient outcome data submitted by more than 150 U.S. transplant centers over an 11-year period to the Center for International Blood and Marrow Transplant Research.

10 Jun 2015

OSU microbiologists discover new type of dairy or food thickener with probiotic characteristics

Microbiologists at Oregon State University have discovered and helped patent and commercialize a new type of dairy or food thickener, which may add probiotic characteristics to the products in which it's used.

10 Jun 2015

Genes News and Research

CQDM, OCE grant $1.5M to speed up drug discovery and development in Quebec-Ontario Life Sciences Corridor

Study highlights discovery of genetic variants linked to mucinous ovarian carcinomas

Researchers uncover new mechanism that innate immune system uses to curb viral infections

Combination of tosedostat and LDAC results in overall response rate of 54% in elderly patients with AML

Molecular classifications of low-grade gliomas proposed

Scientists identify gene mutation linked to anaplastic oligodendroglioma

Researchers working on new system that can detect patient's antibiotic resistance in 30 minutes

Researchers discover new aspect of gene regulation

Study seeks to determine environmental factors that protect against asthma, allergies

Weill Cornell scientists reveal how XBP1 gene can trigger immune responses against ovarian tumors

Certain ARID1a mutations sensitize some tumors to PARP inhibitor drugs

New gene mutations in ADAMTS family may contribute to outcomes in ovarian cancer

PGDx launches LungSelect product to identify genetic alterations in the plasma of NSCLC patients

New insights on crop-rotation resistant rootworms may help develop sustainable agricultural practices

Immune system linked to death of motor neurons in Amyotrophic lateral sclerosis

Research reveals how a faulty gene can cause fatal abnormal heart rhythms during exercise

Researchers investigate how ingested nanoparticles may influence metabolic processes

New study shows that estrogen receptors vanish in cervical cancer tumors

Researchers examine specific causes of mortality after blood and marrow transplant

OSU microbiologists discover new type of dairy or food thickener with probiotic characteristics

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