Insulin Resistance News and Research

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Insulin Resistance is a condition in which the body does not respond to insulin properly. This is most common in Type II diabetes or associated with obesity, ketoacidosis, infection, and certain rare conditions. Diminished effectiveness of insulin in lowering blood glucose levels requiring 200 units or more of insulin per day to prevent hyperglycemia or ketosis.

Blocking Netrin-1 in immune system stops chronic inflammation and insulin resistance tied to obesity

Researchers at NYU Langone Medical Center have found that blocking the action of a key signaling molecule in the immune system known as Netrin-1 stalls chronic inflammation and insulin resistance tied to obesity and often derived from fatty diets.

4 Mar 2014

Link found between pollutants and certain metabolic complications of obesity

A team of researchers at the IRCM in Montr-al led by R-mi Rabasa-Lhoret, in collaboration with J-r-me Ruzzin from the University of Bergen in Norway, found a link between a type of pollutants and certain metabolic complications of obesity. Their breakthrough, published online this week by the Journal of Clinical Endocrinology & Metabolism, could eventually help improve the prevention, diagnosis, and treatment of cardiometabolic risk associated with obesity, such as diabetes, hypertension and cardiovascular disease.

28 Feb 2014

New scientific blood analysis predicts short-term mortality in humans

The general state of a person's metabolism can be diversely illustrated with a new scientific blood analysis. With the aid of the analysis biomarkers predicting short-term mortality have now been discovered

26 Feb 2014

Psychiatrists urged to monitor metabolic changes in psychosis patients

Japanese psychiatrists are largely aware of the metabolic abnormalities that may arise from antipsychotic treatment, but most do not monitor their patients sufficiently, research shows.

30 Jan 2014

Home blood pressure best guide to metabolic risk

Home blood pressure is a good guide to which patients are likely to have the metabolic syndrome, say researchers.

20 Jan 2014

Eating high levels of flavonoids found in berries, tea, and chocolate offer protection from type 2 diabetes

Eating high levels of flavonoids including anthocyanins and other compounds (found in berries, tea, and chocolate) could offer protection from type 2 diabetes - according to research from the University of East Anglia (UEA) and King's College London.

20 Jan 2014

PGC-1α protein found in muscle may contributes to the development of type 2 diabetes later in life

A Montr-al research team led by Jennifer Estall at the IRCM discovered that a protein found in muscle tissue may contribute to the development of type 2 diabetes later in life. The study's results, published in today's printed edition of the scientific journal American Journal of Physiology - Endocrinology and Metabolism, indicate that the protein could be a promising early predictor of increased diabetes risk.

15 Jan 2014

Hormone associated with improved glucose metabolism activates calorie-burning brown fat

Researchers at Joslin Diabetes Center have discovered that a hormone long associated with weight loss and improved glucose metabolism is linked to activation of calorie-burning brown fat.

10 Jan 2014

Dysfunction in MADD gene in mice causes fasting hyperglycemia

Researchers from the University of Illinois at Chicago College of Medicine have found that dysfunction in a single gene in mice causes fasting hyperglycemia, one of the major symptoms of type 2 diabetes. Their findings were reported online in the journal Diabetes.

5 Jan 2014

Researchers reveal how metabolic system breaks down in obesity

Researchers at University of Michigan have illuminated an aspect of how the metabolic system breaks down in obesity. The findings provide additional evidence that a drug entering clinical trials at the university could reverse obesity, Type 2 diabetes and fatty liver disease in humans.

20 Dec 2013

Diabetes blamed for brain neurochemical abnormalities in bipolar disorder

Diabetes may underlie some of the neurochemical abnormalities observed in the brains of patients with bipolar disorder, say researchers.

17 Dec 2013

Lund University researcher explores why type 2 diabetes raises dementia risk later in life

It is well known that type 2 diabetes raises the risk of dementia. The reasons for this are less clear, but one explanation could be insulin resistance in the brain, according to Malin Wennstr-m, a researcher at Lund University's Molecular Memory Research Unit. She has received EUR 700,000 from the Swedish Research Council to investigate her theory.

12 Dec 2013

HCV antiviral therapy also improves diabetes outcomes

Researchers from Taiwan reveal that antiviral therapy for hepatitis C virus improves kidney and cardiovascular outcomes for patients with diabetes. Results of the study published in Hepatology, a journal of the American Association for the Study of Liver Diseases, show that incidences of kidney disease, stroke, and heart attack were lower in patients treated with pegylated interferon and ribavirin compared to HCV patients not treated with antivirals or diabetic patients not infected with the virus.

12 Dec 2013

FDA Advisory Committee recommends metreleptin for treatment of generalized lipodystrophy

AstraZeneca and Bristol-Myers Squibb Company (NYSE:BMY) today announced the U.S. Food and Drug Administration's (FDA) Endocrinologic and Metabolic Drugs Advisory Committee (EMDAC) recommends the investigational medicine metreleptin for the treatment of pediatric and adult patients with generalized lipodystrophy (LD).

12 Dec 2013

Findings hold great promise for potential use of ELABELA as therapeutic molecule for heart diseases

Scientists at A*STAR's Institute of Medical Biology and Institute of Molecular and Cellular Biology have identified a gene encoding a hormone that could potentially be used as a therapeutic molecule to treat heart diseases. The hormone - which they have chosen to name ELABELA - is only 32 amino-acids long, making it amongst the tiniest proteins made by the human body.

9 Dec 2013

Scientists identify gene encoding hormone to treat heart diseases

Scientists at A*STAR's Institute of Medical Biology (IMB) and Institute of Molecular and Cellular Biology (IMCB) have identified a gene encoding a hormone that could potentially be used as a therapeutic molecule to treat heart diseases.

9 Dec 2013

Pro-inflammatory proteins linked to obesity, metabolic syndrome in adults appear to protect young children

The first study of its kind, led by Melinda Sothern, PhD, CEP, Professor and Director of Behavioral and Community Health Sciences at LSU Health Sciences Center New Orleans School of Public Health, reveals that the same pro-inflammatory proteins linked to obesity and the metabolic syndrome in adults appear to protect children prior to puberty.

4 Dec 2013

New finding links obesity and high-fat, high-sugar diets with changes in inflammatory status

Scientists have moved a step closer to an "obesity drug" that may block the effects of diets high in sugar and fats. In a new research report published in the December 2013 issue of The FASEB Journal, scientists show that there is an abnormal amount of an inflammatory protein called PAR2 in the abdominal fat tissue of overweight and obese humans and rats.

3 Dec 2013

Risk factors for Alzheimer's disease

Alzheimer's disease has joined cancer at the top of the list of feared diagnoses, and although Alzheimer's does have the potential to devastate millions of patients and families, there are reasons for hope - and possibly opportunities to reduce risk or alter the course of disease progression, according to Keith Black, MD, professor and chair of the Department of Neurosurgery at Cedars-Sinai.

26 Nov 2013

People who consume nuts daily are 20% less likely to die

In the largest study of its kind, people who ate a daily handful of nuts were 20 percent less likely to die from any cause over a 30-year period than were those who didn't consume nuts, say scientists from Dana-Farber Cancer Institute, Brigham and Women's Hospital, and the Harvard School of Public Health.

21 Nov 2013

Insulin Resistance News and Research

Further Reading

Blocking Netrin-1 in immune system stops chronic inflammation and insulin resistance tied to obesity

Link found between pollutants and certain metabolic complications of obesity

New scientific blood analysis predicts short-term mortality in humans

Psychiatrists urged to monitor metabolic changes in psychosis patients

Home blood pressure best guide to metabolic risk

Eating high levels of flavonoids found in berries, tea, and chocolate offer protection from type 2 diabetes

PGC-1α protein found in muscle may contributes to the development of type 2 diabetes later in life

Hormone associated with improved glucose metabolism activates calorie-burning brown fat

Dysfunction in MADD gene in mice causes fasting hyperglycemia

Researchers reveal how metabolic system breaks down in obesity

Diabetes blamed for brain neurochemical abnormalities in bipolar disorder

Lund University researcher explores why type 2 diabetes raises dementia risk later in life

HCV antiviral therapy also improves diabetes outcomes

FDA Advisory Committee recommends metreleptin for treatment of generalized lipodystrophy

Findings hold great promise for potential use of ELABELA as therapeutic molecule for heart diseases

Scientists identify gene encoding hormone to treat heart diseases

Pro-inflammatory proteins linked to obesity, metabolic syndrome in adults appear to protect young children

New finding links obesity and high-fat, high-sugar diets with changes in inflammatory status

Risk factors for Alzheimer's disease

People who consume nuts daily are 20% less likely to die

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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