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Scientists reveal the possibility to improve immunological memory in vaccines

A key transcription factor in T-cell immunology is crucial to the immune system's "memory" in recognizing threats it has already faced before – and it may be possible to improve this immunological memory in vaccines, according to a new paper by scientists at the Hackensack Meridian Center for Discovery and Innovation.

24 Feb 2022

Advanced gene therapy may prevent severe loss of muscle mass in elderly people

Researchers at NTNU have managed to restore muscle function in older mice with muscle loss using advanced gene therapy. The hope is that this method might eventually be used on humans to prevent severe loss of muscle mass.

24 Feb 2022

Study explores the boosting of SARS-CoV-2 adenovirus vaccine-induced immunity by capsid decoration

Researchers demonstrated that decorating the capsid surface of adenovirus vaccine vectors with a newly discovered protein superglue, DogTag/DogCatcher generates potent SARS-CoV-2-specific humoral and cellular immunity.

24 Feb 2022

Genetic analysis reveals eosinophilic colitis as a unique disease

A condition called eosinophilic colitis is distinct from other, similar eosinophilic gastrointestinal diseases and inflammatory bowel disease, according to a genetic analysis published in Gastroenterology.

24 Feb 2022

Semarion raises £2.14 million GBP ($2.89 million USD) seed funding

Investors include Parkwalk Advisors, University of Cambridge Seed Funds, Martlet Capital, and angel investors.

From Semarion 24 Feb 2022

Foundational characterization of a new bat-borne ebolavirus and its potential as a human pathogen

Researchers sought to evaluate the zoonotic potential of BOMV to assess the level of risk to public health.

24 Feb 2022

Third dose of mRNA-based COVID-19 vaccine efficiently recalls Omicron-reactive B cell memory

A new study examined how the quantity and quality of antibody and memory B cell responses to SARS-CoV-2 change temporally and with the number of exposures to antigens.

24 Feb 2022

Metalloproteinase-dependent entry pathway differentially used by SARS-CoV-2 Delta, Alpha, and Omicron variants

Researchers examined how SARS-CoV-2 variants of concern differentially use an additional metalloproteinase-dependent entry pathway to enter the host cells.

24 Feb 2022

Immunomolecular detection method to rapidly and accurately detect complete SARS-CoV-2 virions

Researchers developed a hybrid assay incorporating immunological antibody-based viral spike protein capture with molecular nucleic acid amplification by qRT-PCR.

24 Feb 2022

SARS-CoV-2 viroporins mediate cytokine storm via mitochondrial permeability transition pore

Researchers demonstrated that the SARS-CoV-2 viroporins precipitate cytokine storm via the alteration of mitochondrial physiology in severe COVID-19.

24 Feb 2022

Study reveals sex-dimorphic immune imprints and in vivo functional impacts of mild COVID-19

Researchers used a systems immunology approach to analyze the immune states of healthy and non-obese subjects who recovered from mild COVID-19 and compared them with age- and sex-matched COVID-19-naive controls.

24 Feb 2022

Immunological landscape of England during Omicron-driven SARS-CoV-2 wave

In a new study, researchers determined the immunological landscape of England throughout the SARS-CoV-2 Omicron wave.

24 Feb 2022

Research reveals why a common genetic variant worsens outcomes for people with ALS and FTD

A pioneering new study led by UCL and National Institutes of Health (NIH) scientists has revealed, for the first time, why a common genetic variant worsens disease outcomes for people with the devastating adult-onset neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

24 Feb 2022

Immune responses in patients with varying degrees of SARS-CoV-2 infection

In a recent research article published in the journal PLoS ONE, researchers looked at immunological responses in relation to established risk factors for serious illness. This prospective cohort study reports on long-lasting SARS-CoV-2 specific antibody and T-cellular immune responses six months after infection in rt-PCR confirmed cases of different illness severity (community and hospitalized patients).

24 Feb 2022

Scientists discover how a rare genetic disorder disrupts key neural interactions in the developing brain

Every time you chew, talk, yawn, or sense the zap of a toothache, cranial nerve cells are shuttling electrochemical signals to your brain.

23 Feb 2022

Study shows how certain RNA molecules control the repair of damaged DNA in cancer cells

A new study from Karolinska Institutet in Sweden shows how certain RNA molecules control the repair of damaged DNA in cancer cells, a discovery that could eventually give rise to better cancer treatments. The study is published today in the journal Nature Communications.

23 Feb 2022

Study on Omicron related mortality in cancer patients during recent COVID wave

A recent pre-proof study published in the journal Cancer Cell assessed the CFR of cancer patients during the third wave of the coronavirus disease 2019 (COVID-19) pandemic caused by the SARS-CoV-2 Omicron variant.

23 Feb 2022

Tiny lipid-based nanoparticles carry genetic instructions directly into the lungs

Researchers at the Tufts University School of Engineering are building a reputation for precision targeting in drug delivery.

23 Feb 2022

Discovery of signaling pathway in immune cells may lead to new therapeutic approach for autoimmune diseases

Autoimmune diseases are triggered when the immune system malfunctions and attacks the body's own structures.

23 Feb 2022

Neanderthal gene makes people susceptible to COVID-19, but protects against HIV

A study recently published in the top-tier journal Proceedings of the National Academy of Sciences of the United States of America (PNAS) shows how a specific gene flow from Neandertals can act as a double-edged sword by increasing the risk for the development of severe coronavirus disease 2019 (COVID-19), and at the same time decreasing the risk for the infection with the human immunodeficiency virus (HIV).

23 Feb 2022

Cell News and Research

Scientists reveal the possibility to improve immunological memory in vaccines

Advanced gene therapy may prevent severe loss of muscle mass in elderly people

Study explores the boosting of SARS-CoV-2 adenovirus vaccine-induced immunity by capsid decoration

Genetic analysis reveals eosinophilic colitis as a unique disease

Semarion raises £2.14 million GBP ($2.89 million USD) seed funding

Foundational characterization of a new bat-borne ebolavirus and its potential as a human pathogen

Third dose of mRNA-based COVID-19 vaccine efficiently recalls Omicron-reactive B cell memory

Metalloproteinase-dependent entry pathway differentially used by SARS-CoV-2 Delta, Alpha, and Omicron variants

Immunomolecular detection method to rapidly and accurately detect complete SARS-CoV-2 virions

SARS-CoV-2 viroporins mediate cytokine storm via mitochondrial permeability transition pore

Study reveals sex-dimorphic immune imprints and in vivo functional impacts of mild COVID-19

Immunological landscape of England during Omicron-driven SARS-CoV-2 wave

Research reveals why a common genetic variant worsens outcomes for people with ALS and FTD

Immune responses in patients with varying degrees of SARS-CoV-2 infection

Scientists discover how a rare genetic disorder disrupts key neural interactions in the developing brain

Study shows how certain RNA molecules control the repair of damaged DNA in cancer cells

Study on Omicron related mortality in cancer patients during recent COVID wave

Tiny lipid-based nanoparticles carry genetic instructions directly into the lungs

Discovery of signaling pathway in immune cells may lead to new therapeutic approach for autoimmune diseases

Neanderthal gene makes people susceptible to COVID-19, but protects against HIV

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