Genes News and Research

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Liverpool scientists complete genomics studies on multidrug resistant Typhoid fever in Africa

The team has completed two genomics studies on the tropical disease, a condition that is estimated to cause up to 30 million illnesses and over a quarter of a million deaths globally each year.

27 May 2015

Study explores how one genome could produce three different castes within bumblebees

Biologists from the University of Leicester have discovered that one of nature's most important pollinators - the buff-tailed bumblebee - either ascends to the status of queen or remains a lowly worker bee based on which genes are 'turned on' during its lifespan.

27 May 2015

UVA scientists find blueprint for combating human disease using DNA clad in near-indestructible armor

By unlocking the secrets of a bizarre virus that survives in nearly boiling acid, scientists at the University of Virginia School of Medicine have found a blueprint for battling human disease using DNA clad in near-indestructible armor.

27 May 2015

Pitt scientists identify two new classes of RNAs closely associated with cancer biomarker

Researchers at the University of Pittsburgh School of Medicine have identified two new classes of RNAs that are closely associated with a protein known to be a prognostic biomarker for breast cancer and could play a role in progression of prostate cancer.

27 May 2015

Mediterranean-style diet can reduce womb cancer risk by half

Women who eat a Mediterranean diet could cut their risk of womb cancer by more than half (57 per cent), according to a study published today (Wednesday) in the British Journal of Cancer.

27 May 2015

Alternative generic strategy for breast cancer treatment

Maxing out the inherently stressed nature of treatment-resistant breast cancer cells thwarts their adaptive ability to evolve genetic workarounds to treatment, a new study suggests.

27 May 2015

Researchers identify six mRNA isoforms that could be used to diagnose early-stage ovarian cancer

Ovarian cancer is notoriously difficult to diagnose and treat, making it an especially fatal disease. Researchers at University of California, San Diego School of Medicine and Moores Cancer Center have now identified six mRNA isoforms (bits of genetic material) produced by ovarian cancer cells but not normal cells, opening up the possibility that they could be used to diagnose early-stage ovarian cancer.

26 May 2015

Researchers identify gene vital to production of pain-sensing neurons in humans

A gene essential to the production of pain-sensing neurons in humans has been identified by an international team of researchers co-led by the University of Cambridge. The discovery, reported today in the journal Nature Genetics, could have implications for the development of new methods of pain relief.

26 May 2015

Scientists uncover role of HTRA3 protease in Cockayne syndrome

Scientists from the Institut Pasteur and CNRS, in collaboration with scientists from the Institut Gustave Roussy and CEA, have succeeded in restoring normal activity in cells isolated from patients with the premature aging disease Cockayne syndrome. They have uncovered the role played in these cells by an enzyme, the HTRA3 protease.

22 May 2015

Phages in chicken meat can transfer antimicrobial resistance to bacteria

Bacteria resistant to antibiotics are on the rise. There are different explanations for how resistances are transferred. Researchers from the Vetmeduni Vienna found phages in chicken meat that are able to transfer antimicrobial resistance to bacteria. Phages are viruses that exclusively infect bacteria. They can contribute to the spread of antimicrobial resistance.

22 May 2015

Decreased removal of toxic peptides causes onset of Alzheimer's disease

Jens Pahnke and his team at the University of Oslo has recently published results in the prestigious scientific journal 'BRAIN' showing that decreased removal of toxic peptides in the brain causes the onset and first clinical signs of Alzheimer's disease, rather than overproduction as has previously been assumed. This information can now be used to target specific genes to enhance their function in the brain of elderly or people at risk.

22 May 2015

Splicing pattern of obesity, type 2 diabetes genes may contribute to pathophysiology of obesity

Alternative splicing of obesity and type 2 diabetes related genes may contribute to the pathophysiology of obesity, according to research from the University of Eastern Finland. Obesity leads to changes in the splicing pattern of metabolically relevant genes such as TCF7L2 and INSR, resulting in impaired insulin action.

22 May 2015

Untangling the Web of Gene Expression

With enhancers and other regulatory elements often lying 10s to 100s of kilobases from the genes they affect, understanding the regulation of gene expression is an incredibly complex endeavor...

From Integrated DNA Technologies 21 May 2015

DF/BWCC introduces new website to provide information about precision cancer medicine

Precision cancer medicine - diagnosis and treatment based on the genetic abnormalities of a specific tumor - is playing an ever-larger role in cancer care. The field got a boost earlier this year when President Barack Obama proposed a $215 million federal Precision Medicine Initiative with cancer as one of its priorities.

21 May 2015

Research may offer new targets for diagnosing, treating advanced prostate cancer

Researchers with the Indiana University School of Medicine have identified a molecule that promotes metastasis of advanced prostate cancer to the bone, an incurable condition that significantly decreases quality of life.

20 May 2015

IDT facilitates versatile, scalable solution to enrich enhancer:promoter interactions

Advancing the development of novel methods for understanding gene expression, Integrated DNA Technologies has enabled Dr Jim Hughes, Associate Professor at the Weatherall Institute of Molecular Medicine, Oxford, UK, to optimize his unique Capture-C method, based on Chromosomal Conformational Capture (3C).

From Integrated DNA Technologies 20 May 2015

Nerve cells guide each other during embryonic development

When nerve cells form in an embryo they do not start off in the right place but have to be guided to their final position by navigating a kind of molecular and cellular "map" in order to function properly. In a recent research study published in Nature Communications neurobiologist Sara Wilson, Umeå University, found that during embryonic development different parts of the nerve cell are important for guiding other nerve cells into their physical positions.

20 May 2015

Johns Hopkins researchers identify new therapy to treat lung cancer

A multidisciplinary team led by Johns Hopkins researcher Venu Raman, Ph.D., with notable contributions from Guus Bol, Farhad Vesuna and Phuoc Tran of Johns Hopkins, has identified a new therapy for lung cancer, the most common cancer worldwide. The therapy has been in development for six years and involves a first-in-class molecule designed by the team.

20 May 2015

Study finds new colon cancer screening as promising alternative to colonoscopy for African Americans

In a first-of-its-kind clinical trial, physician-scientists at University Hospitals Case Medical Center Seidman Cancer Center and Case Western Reserve University School of Medicine found that a new non-invasive technology for colon cancer screening is a promising alternative to colonoscopy for African Americans.

19 May 2015

Researchers uncover mechanism behind common mutation that helps cancer cells replicate limitlessly

More than 500,000 people in the United States die each year of cancer-related causes. Now, emerging research has identified the mechanism behind one of the most common mutations that help cancer cells replicate limitlessly.

19 May 2015

Genes News and Research

Liverpool scientists complete genomics studies on multidrug resistant Typhoid fever in Africa

Study explores how one genome could produce three different castes within bumblebees

UVA scientists find blueprint for combating human disease using DNA clad in near-indestructible armor

Pitt scientists identify two new classes of RNAs closely associated with cancer biomarker

Mediterranean-style diet can reduce womb cancer risk by half

Alternative generic strategy for breast cancer treatment

Researchers identify six mRNA isoforms that could be used to diagnose early-stage ovarian cancer

Researchers identify gene vital to production of pain-sensing neurons in humans

Scientists uncover role of HTRA3 protease in Cockayne syndrome

Phages in chicken meat can transfer antimicrobial resistance to bacteria

Decreased removal of toxic peptides causes onset of Alzheimer's disease

Splicing pattern of obesity, type 2 diabetes genes may contribute to pathophysiology of obesity

Untangling the Web of Gene Expression

DF/BWCC introduces new website to provide information about precision cancer medicine

Research may offer new targets for diagnosing, treating advanced prostate cancer

IDT facilitates versatile, scalable solution to enrich enhancer:promoter interactions

Nerve cells guide each other during embryonic development

Johns Hopkins researchers identify new therapy to treat lung cancer

Study finds new colon cancer screening as promising alternative to colonoscopy for African Americans

Researchers uncover mechanism behind common mutation that helps cancer cells replicate limitlessly

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