Genes News and Research

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METASTROKE refines genetic stroke culprits

An analysis from the METASTROKE collaboration confirms an increased stroke risk associated with four previously reported genetic loci and shows that these are specific to certain stroke subtypes.

12 Oct 2012

Study identifies 21 new gene variants associated with risks of heart disease, metabolic disorders

In the largest-ever genetic study of cholesterol and other blood lipids, an international consortium has identified 21 new gene variants associated with risks of heart disease and metabolic disorders.

12 Oct 2012

Three WSU studies could result in new treatments for epilepsy, behavioral disorders

Three studies conducted as part of Wayne State University's Systems Biology of Epilepsy Project (SBEP) could result in new types of treatment for the disease and, as a bonus, for behavioral disorders as well.

12 Oct 2012

Two CUMC studies provide new insights into spinal muscular atrophy

A study by scientists from the Motor Neuron Center at Columbia University Medical Center (CUMC) suggests that spinal muscular atrophy (SMA), a genetic neuromuscular disease in infants and children, results primarily from motor circuit dysfunction, not motor neuron or muscle cell dysfunction, as is commonly thought.

12 Oct 2012

Single genetic variant in kidney donors' cells may play an important role in transplant longevity

A single genetic variant in kidney donors' cells may help determine whether their transplanted organs will survive long term, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN).

12 Oct 2012

Insight into how coeliac disease is triggered

For the first time, scientists have visualised an interaction between gluten and T-cells of the immune system, providing insight into how coeliac disease, which affects approximately 1 in 133 people, is triggered.

12 Oct 2012

Nelfinavir slows progress of HER2-positive tumor cells

After screening more than 2,300 drugs for their ability to halt the growth of breast cancer cells, Johns Hopkins researchers have discovered that the anti-HIV drug nelfinavir slows the progress of HER2-positive tumor cells, even if they are resistant to other breast cancer drugs.

12 Oct 2012

Protocol allows researchers to generate functional thyroid tissue from stem cells

The generation of functional thyroid tissue from stem cells could allow the treatment of patients, which suffer from thyroid hormone deficiency due to defective function, or abnormal development of the thyroid gland.

12 Oct 2012

Brain scans can identify reading skills of children

If a 7-year-old is breezing through the "Harry Potter" books, studies indicate that he or she will be a strong reader later in life. Conversely, if a 7-year-old is struggling with "The Cat in the Hat," that child will most likely struggle with reading going forward.

12 Oct 2012

NRG1 gene plays an important role in cannabis dependence

A paper by Shizhong Han and colleagues in the current issue of Biological Psychiatry implicates a new gene in the risk for cannabis dependence. This gene, NRG1, codes for the ErbB4 receptor, a protein implicated in synaptic development and function.

12 Oct 2012

Dana-Farber expert offers tips to reduce risk of breast cancer

According to the American Cancer Society, about one in eight women will develop breast cancer in her lifetime. This year, nearly 40,000 women in the United States will die from the disease.

12 Oct 2012

Tissue test detects oral cancer risk

A molecular diagnostic scoring system based on patients’ FOXM1-associated gene messenger RNA expression levels is able to quantitatively diagnose and stratify oral carcinoma and its aggressiveness, show UK and Norwegian study results.

11 Oct 2012

USC project seeks to answer important questions about cancer

Three groups of University of Southern California (USC) researchers-representing medicine, chemistry and chemical engineering-are recipients of highly competitive grants from the National Institutes of Health's National Cancer Institute (NCI).

11 Oct 2012

NCI identifies method by which cancerous mRNA escapes the body's safeguards

In innumerable spy movies, the hero or a villain imprints a key in clay in order to later make an exact copy. In the body, the clay is messenger RNA, or mRNA, which imprints a gene and transfers the plans to a ribosome, where the mRNA's code is manufactured into a protein - the shady shop where the clay imprint becomes a key.

11 Oct 2012

Fibulin-3 protein may help identify mesothelioma in early stages

Researchers at NYU School of Medicine have discovered the protein product of a little-known gene may one day prove useful in identifying and monitoring the development of mesothelioma in early stages, when aggressive treatment can have an impact on the progression of disease and patient prognosis.

11 Oct 2012

New mechanism may alter principle understandings of molecular interactions within a cell's nucleus

Scientists at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory, with collaborators from Harvard University, the University of Madrid, Princeton University, and the University of Zurich, have discovered a new mechanism that may alter principle understandings of molecular interactions within a cell's nucleus.

11 Oct 2012

Six-gene signature can predict survival in men with aggressive prostate cancer

Researchers from Mount Sinai School of Medicine have identified a six-gene signature that can be used in a test to predict survival in men with aggressive prostate cancer, according to new research published in the October issue of The Lancet Oncology.

11 Oct 2012

TSRI scientists identify new gene variants closely associated with bipolar disorder

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have identified small variations in a number of genes that are closely linked to an increased risk of bipolar disorder, a mental illness that affects nearly six million Americans, according to the National Institute of Mental Health.

11 Oct 2012

Spanish and British scientists design new blood test to identify aggressive prostate cancer

Scientists from the Spanish National Cancer Research Centre (CNIO) in Madrid, along with British colleagues from the Institute for Cancer Research (ICR) and the Royal Marsden NHS Foundation Trust, have developed a test that studies genetic patterns in blood cells to detect advanced-stage prostate cancer.

10 Oct 2012

New screening method may lead to more efficient RNA drug development

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have developed a new method of screening more than three million combinations of interactions between RNA and small molecules to identify the best targets on RNA as well as the most promising potential drug compounds.

10 Oct 2012

Genes News and Research

METASTROKE refines genetic stroke culprits

Study identifies 21 new gene variants associated with risks of heart disease, metabolic disorders

Three WSU studies could result in new treatments for epilepsy, behavioral disorders

Two CUMC studies provide new insights into spinal muscular atrophy

Single genetic variant in kidney donors' cells may play an important role in transplant longevity

Insight into how coeliac disease is triggered

Nelfinavir slows progress of HER2-positive tumor cells

Protocol allows researchers to generate functional thyroid tissue from stem cells

Brain scans can identify reading skills of children

NRG1 gene plays an important role in cannabis dependence

Dana-Farber expert offers tips to reduce risk of breast cancer

Tissue test detects oral cancer risk

USC project seeks to answer important questions about cancer

NCI identifies method by which cancerous mRNA escapes the body's safeguards

Fibulin-3 protein may help identify mesothelioma in early stages

New mechanism may alter principle understandings of molecular interactions within a cell's nucleus

Six-gene signature can predict survival in men with aggressive prostate cancer

TSRI scientists identify new gene variants closely associated with bipolar disorder

Spanish and British scientists design new blood test to identify aggressive prostate cancer

New screening method may lead to more efficient RNA drug development

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