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3C-like protease inhibitor clinical candidate, S-217622, as a treatment for SARS-CoV-2

In a new study, a team of researchers discovered S-217622, a non-covalent SARS-CoV-2 3C-like protease (3CLpro) inhibitor clinical candidate for the treatment of COVID-19.

31 Jan 2022

Leica Microsystems ready to welcome researchers at EMBL Imaging Centre

Leica Microsystems, a leading manufacturer of microscopes and scientific instruments, has announced the opening of the new laboratories within the all-new Imaging Centre at the European Molecular Biology Laboratory (EMBL) in Heidelberg. The state-of-the-art imaging centre will serve as an important hub to drive collaborative research.

From Leica Microsystems GmbH 31 Jan 2022

Study finds how a change in cell environment triggers autism with genetic vulnerability

People with autism spectrum disorders all have characteristic behavioral difficulties. Nevertheless, the important heterogeneity of their symptoms remains one of the major questions for scientists and physicians.

31 Jan 2022

Evaluating clinical outcomes and viral loads of SARS-CoV-2 Delta and Omicron infections

The current study showed a marked decrease in disease severity with Omicron compared to the Delta variant.

31 Jan 2022

Prion-like domains in SARS-CoV-2 RBD and ACE2 play important functional roles in viral adhesion and entry

Scientists have recently detected and analyzed viral PrDs in the S protein of SARS-CoV-2, which are the novel regulators of virion assembly.

31 Jan 2022

Binding and conformational properties of the SARS-CoV spike protein and hACE2 complex

A new paper in the journal Molecules describes this in molecular terms, comparing SARS-CoV-2 with an earlier highly pathogenic coronavirus, SARS-CoV.

31 Jan 2022

Vaccine-induced immunological memory is similar for Omicron and Delta SARS-CoV-2 variants

A new study by Norwegian researchers suggests that vaccine-induced immunological memory and the activation of recall responses in the body yields similar coverage for Omicron and Delta variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The paper is currently available on the medRxiv* preprint server while it undergoes peer review.

31 Jan 2022

Research shows minks mimic severe COVID-19 symptoms, including ARDS

Minks may be a suitable animal model for testing severe COVID-19 infections, finds a recent bioRxiv* preprint study. While mice and ferrets are used in preclinical severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is currently no model specific to severe disease.

30 Jan 2022

Study shows homologous COVID boosters better than heterologous in most kidney transplant recipients

Researchers screen kidney transplant recipients to evaluate their serological responses following immunization with three doses of the COVID-19 vaccine.

30 Jan 2022

COVID-19 vaccines elicit cross-reactive antibodies against endemic coronaviruses

Researchers study the interaction between immunity to endemic coronaviruses and SARS-CoV-2.

30 Jan 2022

Scientists evaluate zoonotic potential of NeoCoV, a coronavirus related to MERS-CoV

Researchers identify ACE2 as the functional receptor of the two close relatives of MERS-CoV, NeoCoV and PDF-2180-CoV, in bats.

30 Jan 2022

Using lateral flow testing to define COVID-19 self-isolation period

A recent study discusses the role of lateral flow device testing in potentially improving COVID-19 isolation policies.

30 Jan 2022

Imaging microscopy shows killer T-cells targeting SARS-CoV-2 spike protein

Researchers demonstrate how cytotoxic T-lymphocytes (CTLs) with specificity for SARS-CoV-2 eliminate multiple infected targets.

30 Jan 2022

Study reveals link between muscular dystrophy and sphingolipids

In a new study, the group of Johan Auwerx at EPFL's School of Life Sciences has made the first connection between muscular dystrophy and sphingolipids, a group of bioactive lipids. The study is published in Science Advances.

29 Jan 2022

Scientists assemble carbon nanotubes in a new way to deliver cancer drugs

Fundamental science often finds applications beyond its original focus. Previously, scientists found applications for small diameter carbon nanotube porins in energy technology.

29 Jan 2022

New app and lab kit transform a smartphone into COVID-19 / flu detection system

In a potential game changer for COVID-19 pandemic control efforts, a new cell phone app and lab kit have transformed a smartphone into a COVID-19 / flu detection system.

29 Jan 2022

Research uncovers how lactic acid disrupts the body's defense against tumors

In cancer research, it has long been known that lactic acid, or lactate, is produced in large quantities by cancer cells and that this lactic acid disrupts our defense against tumors.

29 Jan 2022

Damon Runyon Cancer Research Foundation announces newest cohort of Fellows and Breakthrough Scientists

The Damon Runyon Cancer Research Foundation has announced its newest cohort of Damon Runyon Fellows, 13 outstanding postdoctoral scientists conducting basic and translational cancer research in the laboratories of leading senior investigators.

29 Jan 2022

Parasite present in seawater will help to explain how multicellularity developed in animals

Researchers from the UPV/EHU-University of the Basque Country and CEFAS have discovered a parasite present in seawater and which belongs to a primitive lineage; they have named it Txikispora philomaios.

29 Jan 2022

Study may pave the way for mechano-medical approaches to treating abdominal aortic aneurysm

Abdominal aortic aneurysm (AAA) is a complex and life-threatening vascular disease with high incidence worldwide. Termed the silent killer, most AAAs are asymptomatic, often going undetected until rupture, and involve a poorly understood set of mechanical and biochemical events.

28 Jan 2022

Cell News and Research

3C-like protease inhibitor clinical candidate, S-217622, as a treatment for SARS-CoV-2

Leica Microsystems ready to welcome researchers at EMBL Imaging Centre

Study finds how a change in cell environment triggers autism with genetic vulnerability

Evaluating clinical outcomes and viral loads of SARS-CoV-2 Delta and Omicron infections

Prion-like domains in SARS-CoV-2 RBD and ACE2 play important functional roles in viral adhesion and entry

Binding and conformational properties of the SARS-CoV spike protein and hACE2 complex

Vaccine-induced immunological memory is similar for Omicron and Delta SARS-CoV-2 variants

Research shows minks mimic severe COVID-19 symptoms, including ARDS

Study shows homologous COVID boosters better than heterologous in most kidney transplant recipients

COVID-19 vaccines elicit cross-reactive antibodies against endemic coronaviruses

Scientists evaluate zoonotic potential of NeoCoV, a coronavirus related to MERS-CoV

Using lateral flow testing to define COVID-19 self-isolation period

Imaging microscopy shows killer T-cells targeting SARS-CoV-2 spike protein

Study reveals link between muscular dystrophy and sphingolipids

Scientists assemble carbon nanotubes in a new way to deliver cancer drugs

New app and lab kit transform a smartphone into COVID-19 / flu detection system

Research uncovers how lactic acid disrupts the body's defense against tumors

Damon Runyon Cancer Research Foundation announces newest cohort of Fellows and Breakthrough Scientists

Parasite present in seawater will help to explain how multicellularity developed in animals

Study may pave the way for mechano-medical approaches to treating abdominal aortic aneurysm

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