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Eliminating ABCB5-expressing cells crucial for successful colorectal cancer treatment

Researchers at Children's Hospital Boston have found a marker called ABCB5 that both tags a small proportion of cells within colorectal cancers and fuels resistance in those cells to standard treatments. The results indicate that eliminating ABCB5-expressing cells is crucial for successful colorectal cancer treatment, while adding to the growing body of evidence for a theory of cancer growth called the cancer stem cell hypothesis.

9 Jun 2011

Scientists, advocacy experts form new international Foundation for Vaccine Research

Fourteen leading scientists and advocacy experts in vaccines and infectious diseases have announced the formation of a new international Foundation to advance and accelerate vaccine research and development against infectious diseases.

9 Jun 2011

Hepatitis C virus (HCV)-associated liver disease after liver transplantation

Hepatitis C virus (HCV)-associated liver disease continues to be the most common indication for liver transplantation (LT) in the United States accounting for nearly 50% of all liver transplants. Recurrence is universal in patients viremic at the time of transplantation with histological hepatitis developing in the majority of patients. Although the natural history of recurrent HCV is difficult to predict, it is widely accepted that cirrhosis from recurrent HCV occurs in up to 30% of patients within five years of transplantation.

8 Jun 2011

Study determines surfactant protein-D as 'a good predictor' of cardiovascular disease

A blood protein known as surfactant protein-D (SP-D), which is mainly synthesised in the lungs, has been described as "a good predictor" of cardiovascular disease following a large study in North America.

8 Jun 2011

Intercell, Merck terminate V710 Phase II/III trial against S. aureus infection

Merck, known as MSD outside the United States and Canada, and Intercell AG (VSE: ICLL) today announced that following a detailed analysis of the data from the Phase II/III clinical trial evaluating V710, an investigational vaccine for the prevention of Staphylococcus aureus (S. aureus) infection, the independent Data Monitoring Committee (DMC) has unanimously recommended termination of the study.

8 Jun 2011

Maternal-child health disparities need to be addressed in the U.S., says expert

Despite billions of dollars spent on health care each year, the United States ranks 27th out of 33 developed countries for life expectancy at birth. Leading causes of infant mortality are complications related to pre-term birth or low birth weight-outcomes that have been linked with domestic violence.

8 Jun 2011

Lethal malaria parasite has biochemical weakness

Every year, 10,000 pregnant women and up to 200,000 newborn babies are killed by the malaria parasite. Doctors all around the globe have for years been looking in vain for a medical protection, and now researchers from the University of Copenhagen have found the biochemically weakness of the lethal malaria parasite, and will now start developing a vaccine to combat pregnancy related malaria.

8 Jun 2011

Key heart failure therapies could prevent nearly 68,000 deaths each year

A national study has found that nearly 68,000 deaths potentially could be prevented each year by optimally implementing key national guideline-recommended therapies, including critical medications and cardiac devices, for all eligible heart failure patients.

7 Jun 2011

Study explores link between hospital procedure volume, surgical outcomes after joint replacements

Patients who undergo elective total hip or total knee arthroplasty at hospitals with lower surgical volume had a higher risk of venous thromboembolism and mortality following the procedure.

7 Jun 2011

Ovarian cancer screenings do not reduce risk of death

A University of Alabama at Birmingham study released today reports that ovarian cancer screenings do not reduce a woman's risk of death from the disease and the invasive medical procedures may create associated health problems.

7 Jun 2011

Positive results from Celator CPX-351 Phase 2b study on acute myeloid leukemia presented at ASCO

Celator Pharmaceuticals today announced positive clinical results in elderly patients with newly-diagnosed secondary acute myeloid leukemia (sAML) treated with CPX-351 Liposome Injection.

7 Jun 2011

First Edition: June 6, 2011

Kaiser Health News staff writer Christopher Weaver reports: "Short on cash and time, officials in California and at least a dozen other states have turned to philanthropies to help pay for the extra work required under the federal health law".

6 Jun 2011

Study suggests strong link between dying from breast cancer and being obese

Women with a healthy body weight before and after diagnosis of breast cancer are more likely to survive the disease long term, a new study finds. The results will be presented Saturday at The Endocrine Society's 93rd Annual Meeting in Boston.

6 Jun 2011

Study examines disparities in physical fitness levels between two groups

An Indiana University study examining disparities in physical fitness levels between older adults who are patients of safety net community health centers (CHC) and those who are members of a medically affiliated fitness center is producing stunning results.

6 Jun 2011

Women with ovarian cancer do not benefit from CA-125 and transvaginal ultrasound

In a clinical trial that included nearly 80,000 women, those who received ovarian cancer screening did not have a reduced risk of death from ovarian cancer compared to women who received usual care, but did have an increase in invasive medical procedures and associated harms as a result of being screened, according to a study in the June 8 issue of JAMA, a theme issue on cancer.

6 Jun 2011

Older adults with subclinical hyperthyroidism may face higher risk of dying

A common hormone abnormality in older adults—a mild form of overactive thyroid called subclinical hyperthyroidism—is linked to a much higher risk of dying, a new study finds. The results will be presented Sunday at The Endocrine Society's 93rd Annual Meeting in Boston.

6 Jun 2011

HRT reduces risk of breast cancer in women with BRCA mutations after ovary removal

Women with the BRCA1 or BRCA2 gene mutations, which are linked to a very high risk of breast and ovarian cancer, can safely take hormone-replacement therapy (HRT) to mitigate menopausal symptoms after surgical removal of their ovaries, according to new research from the Perelman School of Medicine at the University of Pennsylvania which will be presented Monday, June 6 during the American Society for Clinical Oncology's annual meeting.

4 Jun 2011

UCLA pediatric investigators earn top accolades at TTCF Faculty Presentation Awards

A new therapy for type 1 diabetes? A promising treatment for deadly viruses? Does a common treatment for children with severe infection actually cause more harm than good? These are important questions being investigated by pediatric researchers at Mattel Children's Hospital UCLA.

4 Jun 2011

Hospitals need to measure quality of care

Hospitals that provide quality care for young people do not always provide the same quality care for the elderly, a new study has found.

4 Jun 2011

Research roundup: More spending can lead to better care; Calif. exchange lessons; high-volume hospitals

Medical Spending And The Health Of The Elderly -- Does more medical spending lead to better health care for people over age 64? To answer that question, "researchers from George Mason University and the Urban Institute used data of 17,438 elderly who entered the Medicare Current Beneficiary Survey in the fall of each year from 1991 to 1999, and conducted multiple interviews over three years," according to one description of the study.

4 Jun 2011

Mortality News and Research

Eliminating ABCB5-expressing cells crucial for successful colorectal cancer treatment

Scientists, advocacy experts form new international Foundation for Vaccine Research

Hepatitis C virus (HCV)-associated liver disease after liver transplantation

Study determines surfactant protein-D as 'a good predictor' of cardiovascular disease

Intercell, Merck terminate V710 Phase II/III trial against S. aureus infection

Maternal-child health disparities need to be addressed in the U.S., says expert

Lethal malaria parasite has biochemical weakness

Key heart failure therapies could prevent nearly 68,000 deaths each year

Study explores link between hospital procedure volume, surgical outcomes after joint replacements

Ovarian cancer screenings do not reduce risk of death

Positive results from Celator CPX-351 Phase 2b study on acute myeloid leukemia presented at ASCO

First Edition: June 6, 2011

Study suggests strong link between dying from breast cancer and being obese

Study examines disparities in physical fitness levels between two groups

Women with ovarian cancer do not benefit from CA-125 and transvaginal ultrasound

Older adults with subclinical hyperthyroidism may face higher risk of dying

HRT reduces risk of breast cancer in women with BRCA mutations after ovary removal

UCLA pediatric investigators earn top accolades at TTCF Faculty Presentation Awards

Hospitals need to measure quality of care

Research roundup: More spending can lead to better care; Calif. exchange lessons; high-volume hospitals

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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