Microscopy News and Research

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Study reveals unique molecular mechanisms of stomach’s acid pump

Nagoya University researchers and colleagues have improved understanding of the molecular mechanisms of a key protein that makes the stomach acidic. Their findings, published in the journal Nature Communications, could lead to better drugs for stomach ulcers and shed light on the functions of similar proteins across the human body.

15 Oct 2021

Study reveals a highly effective COVID-19 screening system utilizing a live cell-based assay

A new study reports a cell-based assay that involved the isolation and quantification of SARS-CoV-2 Mpro in human cells in the absence of other proteins.

14 Oct 2021

Small portion of COVID-19 patients infectious long-term

In late December 2019, a novel pneumonia-like lung infection was reported in the Chinese province of Hubei. This, in turn, led to the ongoing coronavirus disease-19 (COVID-19) pandemic. COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is closely related to SARS (Severe Acute Respiratory Syndrome) and MERS (the Middle East Respiratory Syndrome Coronavirus).

13 Oct 2021

Scientists develop an extremely potent siRNA with broad activity against SARS-CoVs

Researchers in Germany have developed a promising approach to suppressing the viral replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

12 Oct 2021

Role of S-acylation in SARS-CoV-2 infectivity

A new study published in Developmental Cell investigates S-acylation of the SARS-CoV-2 S protein.

10 Oct 2021

Wyss Center to lead a collaborative project aimed at improving brain cancer treatment

The Wyss Center announced today that it will lead a collaborative project, as part of Wellcome Leap's Delta Tissue Program, to improve understanding of the brain cancer glioblastoma (GBM) and help develop more effective therapies.

8 Oct 2021

Using AI in biology to unravel how cells fight off invaders

Imagine the day when any tissue or organ can be repaired or the replacements personalized to the patient.

7 Oct 2021

Scientists elucidate the structure of protein complex essential for proper functioning of cells

Scientists at IST Austria describe for the first time the structure of a protein complex essential for our cells to function properly.

7 Oct 2021

Scientists develop a cell-free assay to screen SARS-CoV-2 entry inhibitors

Scientists have developed and validated a cell-free fluorescence assay for the rapid screening of protein inhibitors.

7 Oct 2021

Machine learning and high-powered microscopes provide detailed snapshots of cells' inner machinery

Open any introductory biology textbook, and you'll see a familiar diagram: A blobby-looking cell filled with brightly colored structures – the inner machinery that makes the cell tick.

6 Oct 2021

Novel technique enables 3D visualization of cells containing melanin pigment

To understand the biological underpinnings of skin and hair pigmentation and related diseases such as albinism or melanoma, scientists and doctors need quantitative, three-dimensional information about the architecture, content and location of pigment cells. Penn State College of Medicine researchers have developed a new technique that allows scientists to visualize every cell containing melanin pigment in 3D, in whole zebrafish.

6 Oct 2021

Research project receives DOE funding to reduce the size of scientific data sets

The amount of data produced each year by scientific user facilities such as those at national labs or government organizations can range up to several billion gigabytes per year.

6 Oct 2021

Researchers solve 3D structure of supramolecular protein nanoparticle using cryo-electron microscopy

Nanoparticles and nanocages are attractive materials that may be applied in color agents, catalysts, and drug delivery. For real-world use, it is necessary to produce a large number of nanoparticles of uniform size and shape, but thus far, nanoparticle formation methods using metals have been widely researched, and the formation of nanoparticles with a certain shape and size have been realized.

6 Oct 2021

Inflammatory molecules "trapped" inside micro clots may be the cause of Long COVID symptoms

New research indicates that an overload of various inflammatory molecules, literally "trapped" inside insoluble microscopic blood clots (micro clots), might be the cause of some of the lingering symptoms experienced by individuals with Long COVID.

5 Oct 2021

Using a new public antibody to understand SARS-CoV-2 neutralization

SARS-CoV-2 infects host cells by binding to the angiotensin convertase 2 receptor (ACE2) on the cell surface through its trimeric spike (S) protein. SARS-CoV enters host human cells through endosomes, while SARS-CoV-2 enters through the cell surface and endosomes. The present study published in the journal “Cell Reports” aimed to understand the mechanisms of SARS-CoV-2 antibody neutralization to facilitate the development of therapeutic interventions for COVID-19.

4 Oct 2021

Novel Assay Platform for 3D Microfluidic Cancer Research

AMSBIO have supplied custom Chimeric antigen receptor (CAR)-T products to the University of Strathclyde (UoS) in Glasgow, UK, and ScreenIn3D Ltd, allowing them to perform novel immune-oncology assays in 3D microfluidic cancer models.

From AMS Biotechnology 1 Oct 2021

Early-stage interaction of monocytes with SARS-CoV-2-infected epithelial cell decides COVID-19 severity

A team of scientists from the USA and France has recently unveiled the mechanism of immune dysregulation in coronavirus disease 2019 (COVID-19) patients by analyzing the early-stage interaction between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected epithelial cells and immune cells. The study is currently available on the bioRxiv* preprint server.

30 Sep 2021

Microscopy News and Research

Study reveals unique molecular mechanisms of stomach’s acid pump

Study reveals a highly effective COVID-19 screening system utilizing a live cell-based assay

Small portion of COVID-19 patients infectious long-term

Scientists develop an extremely potent siRNA with broad activity against SARS-CoVs

Role of S-acylation in SARS-CoV-2 infectivity

Wyss Center to lead a collaborative project aimed at improving brain cancer treatment

Using AI in biology to unravel how cells fight off invaders

Scientists elucidate the structure of protein complex essential for proper functioning of cells

Scientists develop a cell-free assay to screen SARS-CoV-2 entry inhibitors

Machine learning and high-powered microscopes provide detailed snapshots of cells' inner machinery

Novel technique enables 3D visualization of cells containing melanin pigment

Research project receives DOE funding to reduce the size of scientific data sets

Researchers solve 3D structure of supramolecular protein nanoparticle using cryo-electron microscopy

Inflammatory molecules "trapped" inside micro clots may be the cause of Long COVID symptoms

Using a new public antibody to understand SARS-CoV-2 neutralization

Novel Assay Platform for 3D Microfluidic Cancer Research

Early-stage interaction of monocytes with SARS-CoV-2-infected epithelial cell decides COVID-19 severity

The new FlowCam® LO improves particle characterization in drug development

Super-resolution imaging and size analysis of SARS-CoV-2 virus particles

Researchers discover working mechanism of potential drug targets for COVID-19

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