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Postnatal gene therapy may be able to prevent or reverse deadly effects of Pitt-Hopkins syndrome

UNC School of Medicine Scientists have shown for the first time that postnatal gene therapy may be able to prevent or reverse many deleterious effects of a rare genetic disorder called Pitt-Hopkins syndrome.

10 May 2022

Study uncovers new regulator of prostate cancer metastasis

A transcription factor normally associated with androgen receptor activity in prostate cancer has a newly discovered role in controlling lipid biosynthesis, according to a Northwestern Medicine study published in Nature Genetics.

10 May 2022

Novel drug target may help overcome resistance to EZH2 inhibitors in SMARCB1 mutated cancers

Inhibitors of the protein EZH2 are effective against cancers with SMARCB1 mutations such as rhabdoid tumors in children.

9 May 2022

Deoxyribonucleic acid nanostructure sensor found to rapidly detect and inhibit SARS-CoV-2

Researchers reported on a three-layer designer deoxyribonucleic acid (DNA) nanostructure (DDN) strategy-based sensor designed by them for rapid and accurate SARS-CoV-2 detection and inhibition.

9 May 2022

Single-cell genomic sequencing identifies a subpopulation of human dopamine neurons that degenerates in Parkinson’s disease

Researchers developed a novel protocol to examine dopamine (DA) neurons extracted from Parkinson’s disease (PD) patients using single-cell genomic sequencing.

9 May 2022

Using PCR-based genotyping to detect SARS-CoV-2 delta-omicron coinfection

In a recently published ‘Letter to the Editor’ in the journal Microbiology Spectrum, scientists have described the procedure of polymerase chain reaction (PCR)-based genotyping in identifying delta-omicron coinfection in clinical samples.

9 May 2022

Potential antiviral targets in SARS-CoV-2

Researchers assessed potential targets in severe acute respiratory syndrome coronavirus 2.

6 May 2022

Scientists explore immunopathology of COVID-19

Researchers explored the interactions between severe acute respiratory syndrome coronavirus 2 and the host in the development of COVID-19.

6 May 2022

Marine bioactive compounds against SARS-CoV-2

A new review paper published in the journal Environmental Science and Pollution Research aimed to determine the possibilities of using biologically active compounds derived from various chemical classes of marine organisms against SARS-CoV-2 infection at various stages of the life cycle of the virus.

6 May 2022

SARS-CoV-2 variants are not evolving to escape from T cell-mediated immunity

In a recent study posted to the bioRxiv* pre-print server, researchers demonstrated that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants did not evolve further to escape from T cell-mediated immunity.

6 May 2022

Prenatal exposure to SARS-CoV-2 raises risk of neurological disorders in infants

In a recent study published in the journal PLOS One, researchers investigated the early indicators of neurological dysfunctions, including the absence of fidgety movements, in three to five-month-old infants prenatally exposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

6 May 2022

Outcomes of COVID-19 treatment with Paxlovid

Researchers investigated the outcomes of COVID-19 treatment with paxlovid.

5 May 2022

Study assesses the efficacy and safety of lithium treatment in patients infected with severe SARS-CoV-2

Researchers assessed the efficacy and safety of using lithium for coronavirus disease 2019 (COVID-19) treatment.

5 May 2022

Potential indirect and direct effects of SARS-CoV-2 on pancreatic islets in patients who became hyperglycemic after COVID-19

In a recent study published in Diabetes, researchers assessed the direct and indirect effects of SARS-CoV-2 on human pancreatic islets.

5 May 2022

Free SARS-CoV-2 spike protein fragments may trigger platelet activation and clot formation in COVID-19

In a recent study under review in the Nature Portfolio journal and currently available on the Research Square* preprint server, researchers investigated the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein (SP) in the thrombi (or blood clots).

5 May 2022

Oral Nirmatrelvir's effects on long COVID symptoms

In a recent study posted to the Research Square* preprint server, researchers at the University of California, San Francisco, examined the cases of three individuals who received nirmatrelvir/ritonavir antiviral therapy at different stages following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

4 May 2022

Bacteria-mediated oral delivery of viral replicon-based mRNA vaccines

Scientists have discussed the possibilities of developing oral replicon-based mRNA vaccines against SARS-CoV-2.

4 May 2022

Evaluating immune protection after third and fourth doses of homologous and heterologous SARS-CoV-2 vaccines among kidney transplant recipients

Researchers evaluated the immune responses after the third and fourth doses of homologous and heterologous mRNA vaccines against COVID-19 in kidney transplant recipients.

4 May 2022

Scientists discover a potential new method of active immunization to prevent Alzheimer's disease

During experiments in animal models, researchers at the University of Kansas have discovered a possible new approach to immunization against Alzheimer's disease (AD).

4 May 2022

Pets living in households with COVID-19 are high likely to seroconvert and become ill

In a recent study published in the journal Emerging Infectious Diseases, researchers investigated whether pet dogs and cats in the households of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected humans were at risk of infection.

3 May 2022

Transcription News and Research

Postnatal gene therapy may be able to prevent or reverse deadly effects of Pitt-Hopkins syndrome

Study uncovers new regulator of prostate cancer metastasis

Novel drug target may help overcome resistance to EZH2 inhibitors in SMARCB1 mutated cancers

Deoxyribonucleic acid nanostructure sensor found to rapidly detect and inhibit SARS-CoV-2

Single-cell genomic sequencing identifies a subpopulation of human dopamine neurons that degenerates in Parkinson’s disease

Using PCR-based genotyping to detect SARS-CoV-2 delta-omicron coinfection

Potential antiviral targets in SARS-CoV-2

Scientists explore immunopathology of COVID-19

Marine bioactive compounds against SARS-CoV-2

SARS-CoV-2 variants are not evolving to escape from T cell-mediated immunity

Prenatal exposure to SARS-CoV-2 raises risk of neurological disorders in infants

Outcomes of COVID-19 treatment with Paxlovid

Study assesses the efficacy and safety of lithium treatment in patients infected with severe SARS-CoV-2

Potential indirect and direct effects of SARS-CoV-2 on pancreatic islets in patients who became hyperglycemic after COVID-19

Free SARS-CoV-2 spike protein fragments may trigger platelet activation and clot formation in COVID-19

Oral Nirmatrelvir's effects on long COVID symptoms

Bacteria-mediated oral delivery of viral replicon-based mRNA vaccines

Evaluating immune protection after third and fourth doses of homologous and heterologous SARS-CoV-2 vaccines among kidney transplant recipients

Scientists discover a potential new method of active immunization to prevent Alzheimer's disease

Pets living in households with COVID-19 are high likely to seroconvert and become ill

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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