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Link between PKC enzyme and kidney disease in diabetes confirmed

Researchers at Joslin Diabetes Center have investigated PKC-beta - a critical enzyme implicated in the devastating complications of type 1 and type 2 diabetes - for more than two decades.

12 Jun 2005

Low birth weight - another risk factor for diabetes

Obesity, physical inactivity, genetics and age have long been recognized as risk factors for developing high blood glucose and diabetes. But over the past few years, scientists have discovered another risk - low birth weight.

10 Jun 2005

Link between hyperglycemia (high blood glucose), overexpression of PKC-beta 2 and kidney disease

Scientists at Joslin Diabetes Center have investigated PKC-beta -- a critical enzyme implicated in the devastating complications of type 1 and type 2 diabetes -- for more than two decades.

10 Jun 2005

Researchers use RNAi libraries to identify regulators of apoptosis and chemoresistance

Using targeted RNA interference, or RNAi libraries, researchers at Harvard Medical School describe the first large-scale classification of kinase and phosphatase gene families on the basis of their role in apoptosis and cell survival. This study appears in the June issue of Nature Cell Biology.

10 Jun 2005

Information to guide child health policy is lacking in the poorest countries with the highest rates of childhood mortality

Around 10.8 million children die worldwide each year. Credible global and national estimates of the burden of disease in childhood are essential for the development of appropriate health policy and implementation of health interventions to prevent these deaths.

9 Jun 2005

Similarities in antiretroviral therapy efficacy in poorer countries to that in industrial nations

Antiretroviral therapy (ART) programs for treating HIV in developing countries are about as effective as ART programs in developed countries, according to an article in the July 15 issue of Clinical Infectious Diseases, now available online.

9 Jun 2005

Molecule called Smad7 may open doors to future treatments in pancreatic and other forms of cancer

Making new strides in their ongoing effort to understand mechanisms behind the relentless growth of cancer cells, researchers at Dartmouth Medical School have found a promising key that may open doors to future treatments in pancreatic and other forms of cancer.

9 Jun 2005

Public report cards may affect angioplasty decisions

Fear of public reporting of mortality rates may explain why cardiologists in New York are less likely than cardiologists in Michigan to perform angioplasty and other percutaneous coronary interventions on higher risk patients, according to a new study in the June 7, 2005, issue of the Journal of the American College of Cardiology.

9 Jun 2005

Novel targets found for the development of drugs to complement, or replace, statins

A team of investigators from the Uppsala Branch of the Ludwig Institute for Cancer Research (LICR) and Harvard Medical School has uncovered novel targets for the development of drugs that would potentially complement, or replace, statins in treating heart disease.

8 Jun 2005

Breast cancer risk nothing like as bad as most women think

While no one would argue that breast cancer is a significant health threat, a new study has found that most women have an exaggerated view of their risk.

7 Jun 2005

Mental health problems in teens go untreated for decades

Researchers in the U.S. say many mental disorders afflicting millions of Americans are often evident in adolescence but usually go untreated for years.

7 Jun 2005

Boring jobs can make your heart bad

British researchers say that dull, steady, boring and unexciting jobs are no good for the heart.

7 Jun 2005

Watch, wait and see, may be best option for babes' ear infections

One of the most common and frequent reasons why doctors prescribe antibiotics to young children is for an ear infection.

7 Jun 2005

Gene therapy for arthritis is both feasible and safe

Gene therapy for arthritis and other non-terminal, debilitating conditions and diseases is both feasible and safe, report researchers who conducted the world's first such test on the approach in patients with advanced rheumatoid arthritis.

6 Jun 2005

Current high school start times deprive adolescents of sleep

Current high school start times deprive adolescents of sleep and force students to perform academically in the early morning, a time of day when they are at their worst, according to a study in the June issue of the journal Pediatrics.

6 Jun 2005

Educating parents and physicians could reduce overuse of antibiotics in children

The most frequent reason pediatricians prescribe antibiotics to young children is for an ear infection (acute otitis media). With increased concerns about high rates of antibiotic use and resistance, recent guidelines suggest consideration of "watchful waiting" for some ear infections to see if they resolve without antibiotics.

6 Jun 2005

Adolescents who are lethargic, cranky and forgetful may have chronic sleep deprivation

Adolescents who are lethargic, cranky and forgetful may have a common ailment: chronic sleep deprivation. But some tired teens may actually have a medical condition such as depression, insomnia, narcolepsy or sleep apnea, warns a new report in Pediatrics.

6 Jun 2005

One-time whooping cough vaccination at 11 years of age may potentially be cost-effective

Despite childhood vaccination rates at all-time highs, pertussis (whooping cough) has re-emerged over the past two decades, especially among adolescents, adults, and young infants. Because of this resurgence, federal health policymakers are considering a national booster vaccination program.

6 Jun 2005

Computer simulation helps understand DNA transcription process

New York University chemists have employed a computer simulation whose results have enhanced scientific understanding of the DNA transcription process. The study, funded by the National Institutes of Health, appears in the June 7 issue of the Proceedings of the National Academy of Sciences.

5 Jun 2005

Discovery will lead to more effective treatments for pulmonary arterial hypertension

A University of Alberta research team has discovered important new information they hope will lead to more effective treatments for pulmonary arterial hypertension (PAH)--a deadly form of high blood pressure in the pulmonary arteries caused by uncontrolled cell growth.

5 Jun 2005

Medical School News and Research

Link between PKC enzyme and kidney disease in diabetes confirmed

Low birth weight - another risk factor for diabetes

Link between hyperglycemia (high blood glucose), overexpression of PKC-beta 2 and kidney disease

Researchers use RNAi libraries to identify regulators of apoptosis and chemoresistance

Information to guide child health policy is lacking in the poorest countries with the highest rates of childhood mortality

Similarities in antiretroviral therapy efficacy in poorer countries to that in industrial nations

Molecule called Smad7 may open doors to future treatments in pancreatic and other forms of cancer

Public report cards may affect angioplasty decisions

Novel targets found for the development of drugs to complement, or replace, statins

Breast cancer risk nothing like as bad as most women think

Mental health problems in teens go untreated for decades

Boring jobs can make your heart bad

Watch, wait and see, may be best option for babes' ear infections

Gene therapy for arthritis is both feasible and safe

Current high school start times deprive adolescents of sleep

Educating parents and physicians could reduce overuse of antibiotics in children

Adolescents who are lethargic, cranky and forgetful may have chronic sleep deprivation

One-time whooping cough vaccination at 11 years of age may potentially be cost-effective

Computer simulation helps understand DNA transcription process

Discovery will lead to more effective treatments for pulmonary arterial hypertension

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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