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KCP protein protects kidneys from damage caused by chronic renal disease and injury

University of Michigan scientists have identified a new and unusual protein that reduces, in laboratory mice, kidney damage caused by chronic renal disease and acute toxic injuries.

28 Mar 2005

Diffusion MRI gives early indication if brain cancer therapy is effective

A special type of MRI scan that measures the flow of water molecules through the brain can help doctors determine early in the course of brain cancer regimen if a patient's tumor will shrink, a new study shows.

28 Mar 2005

Research tool for turning off genes may eventually have therapeutic application

A research team based at Massachusetts General Hospital (MGH) has identified 80 new genes essential to the process of RNA interference (RNAi), a powerful new research tool for inactivating genes in plants or animals.

28 Mar 2005

Three different leukemias are all caused by mutations that alter a specific enzyme controlling blood cell proliferation

Identifying the genetic malfunction that causes these disorders raises the hope that researchers may be able to devise a targeted therapy, just as they have done for chronic myelogenous leukemia (CML), which is presently treated with Gleevec. The three leukemias that share a common genetic cause are polycythemia vera (PV), essential thrombocythemia (ET) and myeloid metaplasia with myelofibrosis (MMM).

28 Mar 2005

Primary care office strategies may increase colon cancer screening

Patients are more likely to receive colorectal cancer screening when primary care practices use an office systems approach, according to an article in the March 28 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

28 Mar 2005

Child care may affect entire community's risks of infection

Any parent knows how quickly a cold or a cough can spread between children who play together. However, child care may also affect an entire community's carriage of potentially dangerous bacteria known as Streptococcus pneumoniae, according to an article in the April 1 issue of Clinical Infectious Diseases, now available online.

28 Mar 2005

Scientists have found genetic regions that, when defective, allow the immune system to attack the pancreas

Scientists at Joslin Diabetes Center have found genetic regions that, when defective, allow the immune system to attack the pancreas -- the first in a series of mis-steps that lead to type 1 diabetes. Armed with these findings, published yesterday, March 22, in the journal Immunity, the researchers are now trying to hone in on the exact genes involved, in mice and in human patients.

23 Mar 2005

Anticonvulsant drug valproate poses greater birth-defect risk than suspected

Use of the anticonvulsant drug valproate during pregnancy may pose a significantly great risk of birth defects than does use of other antiseizure medications.

22 Mar 2005

Bush intervenes in Terri Schiavo case

Terri Schiavo, has been in a permanent vegetative state which is far more severe than a coma, since she had a heart attack in 1990 that deprived her brain of oxygen.

21 Mar 2005

Intervention with once-daily budesonide reduces long-term risk and frequency of severe asthma-related events

New data indicated that earlier intervention with once-daily budesonide, an inhaled corticosteroid delivered by dry powder inhaler to children with mild persistent asthma, significantly reduced the long-term risk and frequency of severe asthma-related events as well as the need for other inhaled medication.

21 Mar 2005

Genomic analysis may one day be a primary diagnostic tool for physicians deciding on a course of treatment for trauma

The researchers showed that state-of-the-art techniques for rapidly analyzing changes in activity of all human genes will likely produce useful insights into the health of critically ill patients. The findings, which are available online and will be published in the March 29 issue of the Proceedings of the National Academy of Sciences, make it possible for physicians to begin answering important questions about critical care through genomic analysis.

21 Mar 2005

Images of brain activity may hold clues to the onset of schizophrenia

Images of brain activity may hold clues to the onset of schizophrenia in people at high risk for the disease, according to a study headed by psychiatry researchers at the University of North Carolina at Chapel Hill School of Medicine.

21 Mar 2005

Rapid rise in obesity may reverse life expectancy trend

It's been assumed that U.S. life expectancy would rise indefinitely, but a new data analysis, published as a special report in the March 17 New England Journal of Medicine, suggests that this trend is about to reverse itself -- due to the rapid rise in obesity, especially among children.

21 Mar 2005

Genetically modified plants are to be used to fight against HIV, tuberculosis, diabetes and rabies

Genetically modified (GM) plants are to be used to grow vaccines for use in the worldwide fight against HIV, tuberculosis, diabetes and rabies thanks to a grant of 12 million euros from the EU’s Sixth Framework Programme (FP6).

21 Mar 2005

RNAi Consortium to accelerate genetic research

Whitehead Institute has joined ten other leading biomedical organizations in an $18 million, three-year public-private consortium that will create a comprehensive library of gene inhibitors to be made available to the entire scientific community.

16 Mar 2005

Q. What turns an obese person into a person with diabetes? - A. Leptin

Twin epidemics of obesity and type 2 diabetes are bearing down on the world's population, threatening the lives of hundreds of millions of people. But scientists are still trying to determine how the two conditions are linked, and what it takes to turn an obese person into a person with diabetes.

16 Mar 2005

Aspirin use appears to reduce the incidence of colon polyps

The association between regular aspirin use and a reduced risk of precancerous colon polyps may be strongest in those with particular genetic variants.

15 Mar 2005

Researchers investigate the interaction of proteins responsible for Saethre-Chotzen Syndrome

A study in the April issue of Nature Genetics establishes a model that may take scientists closer to understanding how cells in the human body determine their own fate.

15 Mar 2005

Selenium, vitamin E and the tomato nutrient lycopene have been shown to reduce prostate cancer

Greater levels of selenium, vitamin E and the tomato nutrient lycopene have been shown to reduce prostate cancer in one out of every four Caucasian males - those who inherit a specific genetic variation that's particularly sensitive to oxidative stress.

15 Mar 2005

Drug therapy may be comparable to invasive cardiac procedures for elderly patients with heart attack

Although the type and intensity of treatment for acute myocardial infarction (AMI) [heart attack] varies widely across the country, elderly patients who receive intensive medical treatment may have comparable survival as those who undergo invasive cardiac procedures (such as angioplasty and bypass surgery), according to a study in the March 16 issue of JAMA.

15 Mar 2005

Medical School News and Research

KCP protein protects kidneys from damage caused by chronic renal disease and injury

Diffusion MRI gives early indication if brain cancer therapy is effective

Research tool for turning off genes may eventually have therapeutic application

Three different leukemias are all caused by mutations that alter a specific enzyme controlling blood cell proliferation

Primary care office strategies may increase colon cancer screening

Child care may affect entire community's risks of infection

Scientists have found genetic regions that, when defective, allow the immune system to attack the pancreas

Anticonvulsant drug valproate poses greater birth-defect risk than suspected

Bush intervenes in Terri Schiavo case

Intervention with once-daily budesonide reduces long-term risk and frequency of severe asthma-related events

Genomic analysis may one day be a primary diagnostic tool for physicians deciding on a course of treatment for trauma

Images of brain activity may hold clues to the onset of schizophrenia

Rapid rise in obesity may reverse life expectancy trend

Genetically modified plants are to be used to fight against HIV, tuberculosis, diabetes and rabies

RNAi Consortium to accelerate genetic research

Q. What turns an obese person into a person with diabetes? - A. Leptin

Aspirin use appears to reduce the incidence of colon polyps

Researchers investigate the interaction of proteins responsible for Saethre-Chotzen Syndrome

Selenium, vitamin E and the tomato nutrient lycopene have been shown to reduce prostate cancer

Drug therapy may be comparable to invasive cardiac procedures for elderly patients with heart attack

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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