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Future diabetes drugs may target new protein interaction

In the March 3 issue of Nature, Johns Hopkins researchers report that two proteins best known for very different activities actually come together to turn the liver into a sugar-producing factory when food is scarce.

2 Mar 2005

HAART saves 2 million life years

The total impact of HIV treatment in the US has been evaluated for the first time. Dr. Rochelle Walensky, ( Harvard Medical School in Boston), speaking at the 12th Annual Retrovirus Conference, quoted from research which estimated the survival benefits of highly active antiretroviral therapy (HAART) and opportunistic infection prophylaxis in the US from 1989 to 2003.

2 Mar 2005

Children can benefit from surgery for sleep apnea

Times have changed. Within the last ten years, the primary reason that children have had surgery to remove their tonsils and adenoids is not because of infection. Instead, up to 90 percent of the adenotonsillectomy surgeries are to correct obstructive sleep apnea (OSA).

1 Mar 2005

Intravenous vitamin D appears to significantly improve the survival of patients on dialysis

The administration of intravenous vitamin D appears to significantly improve the survival of patients on dialysis, according to a study that will be published in the April Journal of the American Society of Nephrology.

28 Feb 2005

First study to show cost-effectiveness of pre-diabetes intervention

More than 40 million Americans face a high risk of developing Type 2 diabetes, and it would cost a lot to give all of them intensive help with diet and exercise, or medication, to keep them from developing diabetes.

28 Feb 2005

New study following 12,574 individuals over the course of three years of HAART

Although clinical progression to AIDS of patients infected with Human immunodeficiency virus (HIV) has declined since the introduction of Highly Active Antiretroviral Therapy (HAART), there is little data on the changes in incidence of AIDS-defining events during the first few years of therapy.

28 Feb 2005

Self-reporting of symptoms by patients with ulcerative colitis better than assessing patients with endoscopy

People living with fatigue, abdominal discomfort and bloody diarrhea caused by the chronic inflammation of ulcerative colitis may no longer need to undergo frequent and uncomfortable endoscopies, a new study shows.

27 Feb 2005

Scientists have regenerated a damaged optic nerve

This achievement, which occurred in laboratory mice and is described in the March 1, 2005 issue of the Journal of Cell Science, holds great promise for victims of diseases that destroy the optic nerve, and for sufferers of central nervous system injuries.

24 Feb 2005

First study to explore the use of biofeedback as a complementary treatment to asthma medication

For the estimated 20.3 million adults and 6.3 million children in the U.S. who suffer from asthma, the primary treatment is the use of medications to help reduce the underlying inflammation in the airways.

22 Feb 2005

Secreted signaling protein called Wnt10b secret to new drugs for preventing or treating osteoporosis

Leaping tall buildings in a single bound may be out of the question, but the genetically engineered "supermice" in Ormond MacDougald's laboratory at the University of Michigan Medical School are definitely stronger than average.

22 Feb 2005

Why some lung cancers stop responding to the drugs erlotinib (Tarceva) and gefitinib (Iressa)

Researchers at Memorial Sloan-Kettering Cancer Center (MSKCC) have found an explanation for why some lung cancers stop responding to the drugs erlotinib (Tarceva) and gefitinib (Iressa).

22 Feb 2005

New compound, AMN107, 20 times more potent than Gleevec for chronic myelogenous leukemia treatment

A laboratory study led by researchers at Dana-Farber Cancer Institute has shown that a potent and highly selective therapy for chronic myelogenous leukemia (CML) may ultimately be more effective than Gleevec®, the current standard of care.

21 Feb 2005

As little as one drink per week may harm your baby

Expectant mothers should be advised not to drink alcohol, as this may pose health risks to the foetus, argues an editorial in this week's BMJ.

20 Feb 2005

Olmesartan improves blood supply to kidneys

How do medications that block the renin-angiotensin system (RAS blockers) work to protect against kidney disease in people with diabetes? At least partly by improving the blood supply to the kidneys, suggests a study in the April Journal of the American Society of Nephrology.

17 Feb 2005

Programmed cell death may provide clues to cancer and autoimmune diseases therapies

Dartmouth Medical School geneticists have found links in the cell death machinery of worms and mammals, opening new avenues for studying and targeting a process vital to development and implicated in cancer and autoimmune diseases.

16 Feb 2005

Angiogenesis inhibitor molecules defend against the development and spread of cancer

Research led by investigators at Beth Israel Deaconess Medical Center (BIDMC) helps explain how a group of angiogenesis inhibitor molecules serve as an important defense mechanism against the development and spread of cancer, offering key insights into why cancerous tumors grow at different rates among different individuals.

15 Feb 2005

Heart specialists increasingly fear that the lack of women in cardiology

Heart specialists increasingly fear that the lack of women in cardiology, despite growing numbers of female medical students, will bring down standards of practice and research in the specialty, reveals a British Cardiac Society report.

14 Feb 2005

Scientists show knocking out key signals will cause diabetes

Using a revolutionary technique to turn off chemical signals inside the cell, scientists at Joslin Diabetes Center have discovered that the different metabolic abnormalities present in type 2 diabetes can be caused by knocking out two key signals in liver cells.

11 Feb 2005

Simple drug has the potential to save many lives threatened by malaria

A simple drug, given to children with severe malaria before they reach hospital, has the potential to save many lives, say researchers in this week's BMJ.

10 Feb 2005

Expanded HIV screening can increase patient life span

Expanded HIV screening can increase patient life span, prevent the spread of the disease, and is cost effective, researchers at Yale, Harvard and the Massachusetts General Hospital report in the February 10 issue of the New England Journal of Medicine (NEJM).

10 Feb 2005

Medical School News and Research

Future diabetes drugs may target new protein interaction

HAART saves 2 million life years

Children can benefit from surgery for sleep apnea

Intravenous vitamin D appears to significantly improve the survival of patients on dialysis

First study to show cost-effectiveness of pre-diabetes intervention

New study following 12,574 individuals over the course of three years of HAART

Self-reporting of symptoms by patients with ulcerative colitis better than assessing patients with endoscopy

Scientists have regenerated a damaged optic nerve

First study to explore the use of biofeedback as a complementary treatment to asthma medication

Secreted signaling protein called Wnt10b secret to new drugs for preventing or treating osteoporosis

Why some lung cancers stop responding to the drugs erlotinib (Tarceva) and gefitinib (Iressa)

New compound, AMN107, 20 times more potent than Gleevec for chronic myelogenous leukemia treatment

As little as one drink per week may harm your baby

Olmesartan improves blood supply to kidneys

Programmed cell death may provide clues to cancer and autoimmune diseases therapies

Angiogenesis inhibitor molecules defend against the development and spread of cancer

Heart specialists increasingly fear that the lack of women in cardiology

Scientists show knocking out key signals will cause diabetes

Simple drug has the potential to save many lives threatened by malaria

Expanded HIV screening can increase patient life span

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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