Clinical Trial News and Research

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New CAR T-cell therapy shows promise against aggressive HER2+ breast cancer

One-third of HER2-positive (HER2+) tumors express the P95HER2 protein, which associates with an aggressive form of breast cancer with a poorer prognosis. Investigators of the Vall d'Hebron Institute of Oncology's (VHIO) Growth Factors Group, in collaboration with researchers of the Cancer Research Program of Hospital del Mar Research Institute (HMRI), Barcelona, have developed novel chimeric antigen receptor (CAR) T-cell therapy that can produce a potent antitumor response against p95HER2-expressing cells.

19 Nov 2024

Study reveals the power of sleep in enhancing motor learning for individuals with brain injury

New research published by scientists at Kessler Foundation provides critical insights into the role of sleep in motor learning for individuals recovering from traumatic brain injury (TBI).

19 Nov 2024

Study: 40% of newly diagnosed heart failure patients also have atrial fibrillation

A new study by researchers at Intermountain Health in Salt Lake City finds that 40 percent of newly diagnosed heart failure patients also have atrial fibrillation – a combination of cardiac disorders that researchers found results in significantly poorer outcomes for patients.

19 Nov 2024

New nasal spray form of bumetanide shows promise for heart failure treatment

A new nasal spray form of the medication bumetanide may reduce the tissue swelling caused by heart failure as effectively as the standard oral and intravenous formulations of the medication, according to late-breaking science presented today at the American Heart Association's Scientific Sessions 2024.

19 Nov 2024

Adding high-dose IV vitamin C to chemotherapy can boost survival for pancreatic cancer patients

Results from a randomized phase 2 clinical trial show that adding high-dose, intravenous (IV) vitamin C to chemotherapy doubles the overall survival of patients with late-stage metastatic pancreatic cancer from eight months to 16 months.

19 Nov 2024

NIH develops AI algorithm to streamline clinical trial matching

Researchers from the National Institutes of Health (NIH) have developed an artificial intelligence (AI) algorithm to help speed up the process of matching potential volunteers to relevant clinical research trials listed on ClinicalTrials.gov.

18 Nov 2024

Common heart failure drug reduces risk of chemotherapy-induced heart damage in cancer patients

A commonly prescribed medication for heart failure was linked to a lower risk of heart damage, or cardiotoxicity, among high-risk cancer patients undergoing chemotherapy treatment using anthracyclines, according to preliminary late-breaking science presented today at the American Heart Association's Scientific Sessions 2024.

18 Nov 2024

Daily tablet shows promise in treating achondroplasia in children

A promising daily tablet is effective at increasing height and improving proportional limb growth in children with achondroplasia, the most common form of dwarfism, according to a new study.

18 Nov 2024

Proactively screening diabetes patients for heart disease does not improve long-term survival

While coronary heart disease and diabetes are often seen in the same patients, a diagnosis of diabetes does not necessarily mean that patients also have coronary heart disease, according to a new study from researchers at Intermountain Health in Salt Lake City.

18 Nov 2024

New risk score identifies heart disease risk in kidney transplant patients

Using an innovative risk score assessment score, heart researchers at Intermountain Health in Salt Lake City say they can accurately predict whether patients being assessed for kidney transplant will likely have a future major cardiac event, like a heart attack or stroke, according to a new study.

18 Nov 2024

Blood pressure control improved with dual medication pills in India

Medication variations that combined two of three different blood pressure-lowering medications into a single pill worked equally well in reducing blood pressure and were safe among adults in India, according to late-breaking science presented today at the American Heart Association's Scientific Sessions 2024.

18 Nov 2024

Hypertension drug may reduce heart failure risk in people recovering from heart attack

New research found that the medication spironolactone, often prescribed for hypertension (high blood pressure), may reduce the risk of heart failure in people recovering from a heart attack.

18 Nov 2024

Intravenous infusion of exenatide fails to reduce risks of complications in heart surgery patients

A large-scale clinical trial found that intravenous infusion of exenatide, a glucagon-like peptide-1 (GLP-1) analog medication, during heart surgeries involving bypass did not significantly reduce the risk of death, stroke or organ failure.

18 Nov 2024

SGLT2 inhibitor canagliflozin shown to improve kidney oxygenation in diabetes patients

Type 2 diabetes can lead to diabetic kidney disease, but a class of drugs that cause the kidneys to remove glucose through urine has been gaining attention.

18 Nov 2024

New clinical trial offers hope for patients with rare immune disease IgG4-RD

A team led by Mass General Brigham researchers demonstrated that inebilizumab reduced the risk of symptoms by 87% in patients with the rare affliction known as immunoglobulin G4–related disease (IgG4-RD)

18 Nov 2024

Neoantigen DNA vaccines improve survival and immunity in triple-negative breast cancer patients

A new phase 1 trial demonstrates the safety and effectiveness of personalized neoantigen DNA vaccines, showing promising immune responses and improved recurrence-free survival in high-risk triple-negative breast cancer patients.

17 Nov 2024

Blue light exposure may accelerate bone growth and early puberty in rats

Exposure to blue light, like that from smartphones or tablets, may accelerate bone growth and bone age, leading to early puberty in rats.

15 Nov 2024

Duke-NUS team develops test to monitor engineered T cells in cancer treatment

A novel test developed by Duke-NUS researchers enables real-time monitoring of T cells that have been engineered to fight cancer, after re-introduction into the body of a cancer patient.

15 Nov 2024

International team releases recommendations for AI use in neuro-oncology

An international, multidisciplinary team of leading neuro-oncology researchers and clinicians has released new recommendations for good clinical practice - a set of guidelines that helps ensure clinical trial results are reliable, and patients are protected - regarding the use of artificial intelligence methods to more accurately diagnose, monitor and treat brain cancer patients.

15 Nov 2024

Cognitive behavioral therapy shows promise for prolonged grief disorder

Integrative cognitive behavioral therapy shows greater efficacy than present-centered therapy in reducing grief severity and comorbid symptoms after treatment.

15 Nov 2024

Clinical Trial News and Research

New CAR T-cell therapy shows promise against aggressive HER2+ breast cancer

Study reveals the power of sleep in enhancing motor learning for individuals with brain injury

Study: 40% of newly diagnosed heart failure patients also have atrial fibrillation

New nasal spray form of bumetanide shows promise for heart failure treatment

Adding high-dose IV vitamin C to chemotherapy can boost survival for pancreatic cancer patients

NIH develops AI algorithm to streamline clinical trial matching

Common heart failure drug reduces risk of chemotherapy-induced heart damage in cancer patients

Daily tablet shows promise in treating achondroplasia in children

Proactively screening diabetes patients for heart disease does not improve long-term survival

New risk score identifies heart disease risk in kidney transplant patients

Blood pressure control improved with dual medication pills in India

Hypertension drug may reduce heart failure risk in people recovering from heart attack

Intravenous infusion of exenatide fails to reduce risks of complications in heart surgery patients

SGLT2 inhibitor canagliflozin shown to improve kidney oxygenation in diabetes patients

New clinical trial offers hope for patients with rare immune disease IgG4-RD

Neoantigen DNA vaccines improve survival and immunity in triple-negative breast cancer patients

Blue light exposure may accelerate bone growth and early puberty in rats

Duke-NUS team develops test to monitor engineered T cells in cancer treatment

International team releases recommendations for AI use in neuro-oncology

Cognitive behavioral therapy shows promise for prolonged grief disorder

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