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New preclinical data from Regulus' miR-21 study on kidney fibrosis

Regulus Therapeutics Inc., a biopharmaceutical company leading the discovery and development of innovative medicines targeting microRNAs, today announced that new preclinical data investigating the role of microRNA-21 (miR-21) in the treatment of kidney fibrosis has been published in the journal Science Translational Medicine.

17 Feb 2012

Low choline intake increases risk of liver scarring in menopausal women with NAFLD

Menopausal women with non-alcoholic fatty liver disease (NAFLD) who don't consume enough of the essential nutrient choline appear to be at higher risk for liver scarring, according to research led by scientists at Johns Hopkins Children's Center.

17 Feb 2012

New genetic resource to accelerate development of novel treatments for diseases

A new genetic resource from an international research consortium is expected to accelerate the development of new cures and treatments for a wide range of human diseases. This project, called the mouse "Collaborative Cross" (CC) resource, will increase the likelihood that experiments conducted in mice will advance our understanding of human biology.

17 Feb 2012

Collaborative Cross can help fast-track key discoveries about genetics and disease

A series of 15 scientific papers published this week in the journals of the Genetics Society of America (Genetics and G3: Genes|Genomes|Genetics) put North Carolina at the epicenter of a scientific resource called the Collaborative Cross - a "library" of genetic diversity that scientists believe can help fast-track important discoveries about genetics and disease into new discoveries, tests, and treatments that impact human health.

17 Feb 2012

Researchers obtain sequence of 168 complete genomes of fruit fly

Discovering the relation between genetic variation and observable characteristics of individuals belonging to a species, such as a person's height or the manifestation of a hereditary disease is one of today's challenges in biology. Until now only a small part of the variation of these traits - which biologists name phenotypes - were attributed to genetic variations.

17 Feb 2012

Synthetic Oct4 protein more effective at turning genes into pluripotent stem cells

Scientists have found a way to generate and maintain stem cells much more efficiently by amplifying the effect of an essential protein.

17 Feb 2012

Mechanical dose of load through muscle force may slow bone loss in SCI patients

Loss of bone density leads to brittle bones that fracture easily. It is a major complication of spinal cord injury (SCI), which affects about 250,000 Americans every year.

17 Feb 2012

Exposure to common flame retardant may affect fertility and long-term memory

Mice genetically engineered to be susceptible to autism-like behaviors that were exposed to a common flame retardant were less fertile and their offspring were smaller, less sociable and demonstrated marked deficits in learning and long-term memory when compared with the offspring of normal unexposed mice, a study by researchers at UC Davis has found.

16 Feb 2012

MDC researcher receives ERC grant for transposon study

Dr. Zsuzsanna Izsv-k, research group leader at the Max Delbr-ck Center for Molecular Medicine (MDC) Berlin-Buch, has been named recipient of a European Research Council (ERC Advanced) grant worth EUR 1.94 million for her research on "jumping genes."

16 Feb 2012

Study aims to eradicate the most common cause of food poisoning

Eliminating the most common cause of food poisoning from the food chain is the aim of new research funded by the Biotechnology and Biological Sciences Research Council (BBSRC) and the world-leading UK-based poultry breeding company Aviagen.

16 Feb 2012

Complex computer program helps analyze RNA structural motifs

Computer engineers may have just provided the medical community a new way of figuring out exactly how one of the three building blocks of life forms and functions.

16 Feb 2012

First study to evaluate motor impairments in children with ASD

Children with autism often have problems developing motor skills, such as running, throwing a ball or even learning how to write. But scientists have not known whether those difficulties run in families or are linked to autism. New research at Washington University School of Medicine in St. Louis points to autism as the culprit.

16 Feb 2012

Pyromaker can rapidly sequence cancer-driving mutations

Using precise information about an individual's genetic makeup is becoming increasingly routine for developing tailored treatments for breast, lung, colon and other cancers. But techniques used to identify meaningful gene mutations depend on analyzing sequences of both normal and mutant DNA in tumor samples, a process that can yield ambiguous results. Now, a team of Johns Hopkins researchers says it has developed an easy-to-use online computer software application that can clear up any confusion faster and cheaper than other methods currently used to do the job.

16 Feb 2012

Oxford Gene Technology develops optimised rare disease sequencing and analysis service

Oxford Gene Technology (OGT), a provider of innovative clinical genetics and diagnostic solutions to advance molecular medicine, has extended its Genefficiency™ Sequencing Service to provide a dedicated service for investigating rare diseases. The specifically optimised version of the service will help investigators and clinicians identify causative mutations quickly, easily and without the need for in-house technical or bioinformatics expertise.

From Oxford Gene Technology 16 Feb 2012

WSU's novel gene-therapy for blindness receives $250,000 FFB grant

Technology to restore vision through the use of a component of green algae - developed by a Wayne State University professor and scientific director of the Ligon Research Center of Vision at the Kresge Eye Institute - has attracted additional funding for therapy development.

16 Feb 2012

TFF3 protein plays a more sinister role in breast cancer metastasis

The trefoil factor 3 (TFF3) protein protects and maintains the integrity of the epithelial surface in the normal breast. New research has found that while TFF3 protein expression is higher in well-differentiated low grade tumors and therefore associated with features of a good prognosis, it has a more sinister role in breast cancer invasion and metastasis.

16 Feb 2012

Researchers identify potent regulator of sensitivity to insulin

Researchers at Washington University School of Medicine in St. Louis have identified a potent regulator of sensitivity to insulin, the hormone that controls blood sugar levels. The new findings may help scientists find better treatments for type 2 diabetes, obesity and other health problems caused by the body's inability to properly regulate blood sugar.

16 Feb 2012

Ovarian cancer subtype may be susceptible to 'anti-angiogenic' drugs

Scientists at Dana-Farber Cancer Institute have identified a subtype of ovarian cancer able to build its own blood vessels, suggesting that such tumors might be especially susceptible to "anti-angiogenic" drugs that block blood vessel formation.

15 Feb 2012

Chemists create new molecule that can tangle inside the DNA for up to 16 days

Chemists at The University of Texas at Austin have created a molecule that's so good at tangling itself inside the double helix of a DNA sequence that it can stay there for up to 16 days before the DNA liberates itself, much longer than any other molecule reported.

15 Feb 2012

23andMe, Cleveland Clinic to discover how genes and environment influence PD

In an effort to study the interactions between genomics and Parkinson's disease, Cleveland Clinic has joined the ongoing efforts of 23andMe, a leading personal genetics company, to recruit Parkinson's patients to participate in research by contributing their DNA to a research database and completing online surveys about their health.

15 Feb 2012