Clinical Trial News and Research

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New research identifies key subtype of bacterial vaginosis that increases chlamydia risk

Women who develop bacterial vaginosis (BV) often later acquire chlamydia, a common and potentially serious sexually transmitted bacterial infection.

16 Jan 2025

T-DM1 reduces long-term risk of death in HER2-positive breast cancer patients

In patients with high-risk HER2-positive breast cancer, post-surgery, or adjuvant, treatment with trastuzumab emtansine (T-DM1) reduced the long-term risk of death or invasive disease by 46% and improved survival compared to trastuzumab alone, according to the final results of the phase 3 KATHERINE clinical trial led by researchers from the University of Pittsburgh and UPMC Hillman Cancer Center.

16 Jan 2025

CGM data offers superior insights into diabetes complications

Data from continuous glucose monitors can predict nerve, eye and kidney damage caused by type 1 diabetes, University of Virginia Center for Diabetes Technology researchers have found. That suggests doctors may be able to use data from the devices to help save patients from blindness, diabetic neuropathy and other life-changing diabetes complications.

16 Jan 2025

Xenon gas offers potential neuroprotective effects for Alzheimer's patients

Most treatments being pursued today to protect against Alzheimer's disease focus on amyloid plaques and tau tangles that accumulate in the brain, but new research from Mass General Brigham and Washington University School of Medicine in St. Louis points to a novel-and noble-approach: using Xenon gas.

16 Jan 2025

Antihistamine shows promise for treating rare genetic liver disease

A common antihistamine may offer hope for patients with a rare genetic disease that can lead to severe liver damage and ultimately require transplantation, according to new research from Rutgers Health.

16 Jan 2025

Pheno Therapeutics receives clinical trial authorization for novel multiple sclerosis therapeutic

Pheno Therapeutics Limited., a biotechnology company focused on the discovery and development of small molecule therapeutics for the treatment of neurological diseases, announced today it has received clinical trial authorization (CTA) from the UK’s MHRA (Medicines and Healthcare products Regulatory Agency) for its lead candidate, PTD802.

15 Jan 2025

Groundbreaking trial finds levofloxacin effective against multidrug-resistant TB

A clinical trial published in the New England Journal of Medicine showed that the oral antibiotic levofloxacin taken once-daily for six months substantially reduced the risk of developing drug-resistant tuberculosis (TB), and almost halved adults' and children's risk of developing multidrug-resistant TB.

15 Jan 2025

PIN1 protein found to be a significant driver of bladder cancer

Like all cancers, bladder cancer develops when abnormal cells start to multiply out of control. But what if we could put a lid on their growth?

15 Jan 2025

Lifestyle support shows promise in reducing chronic back pain disability

Low back pain is a leading cause of disability worldwide with many treatments, such as medication, often failing to provide lasting relief.

15 Jan 2025

Pheno Therapeutics granted clinical trial authorization for lead multiple sclerosis therapeutic candidate PTD802

From Pheno Therapeutics 15 Jan 2025

CAR-NK cells offer safer, more accessible treatment for lymphoma

A new type of cell-based immunotherapy shows promise for B-cell lymphomas and - due to innovations in manufacturing - could make future cellular immunotherapies less expensive and more accessible to patients.

15 Jan 2025

No short-term benefit found for PCT-guided antibiotic treatment in children

A groundbreaking UK study in The Lancet has examined whether an additional blood test called procalcitonin (PCT) could safely shorten the time children spend on intravenous (IV) antibiotics in hospitals.

15 Jan 2025

New drug cocktail enhances CAR-T cells for cancer treatment

Preclinical research findings from the University of North Carolina Lineberger Comprehensive Cancer Center identified a cocktail of three different drugs that can be used to generate more robust immune system CAR-Ts (chimeric antigen receptor-T cells) to fight cancer.

13 Jan 2025

Research highlights changing trends in ADHD diagnoses among adolescents and adults

New research identifies differing trends in attention-deficit/hyperactivity disorder (ADHD) diagnoses among adolescents and adults, including an increase among adults from 2020 to 2023.

13 Jan 2025

Study reveals route of entry for Semliki Forest virus into the brain

In a recent study, researchers from Uppsala University show that the Semliki Forest virus enters the central nervous system by first entering the cerebrospinal fluid and then binding to a specific cell type before penetrating deeper into the brain.

13 Jan 2025

Boston Scientific announces agreement to acquire Bolt Medical, Inc.

Boston Scientific Corporation today announced it has entered into a definitive agreement to acquire Bolt Medical, Inc., the developer of an intravascular lithotripsy (IVL) advanced laser-based platform for the treatment of coronary and peripheral artery disease.

From Boston Scientific 13 Jan 2025

UTHealth project aims to improve clinical trials for underserved people with neurological conditions

In an effort to close the gap in neurological outcomes for underserved populations, a UTHealth Houston project funded with $2.9 million from the National Institutes of Health (NIH) will engage community partners to improve the design of clinical trials.

10 Jan 2025

Innovative tablet combination shows promise in fighting Trichuris trichiura and other helminths

A new tablet combining albendazole and ivermectin is safe and more effective than albendazole alone in treating Trichuris trichiura and other soil-transmitted helminths (STH), according to a clinical trial conducted by the STOP consortium and led by the Barcelona Institute of Global Health (ISGlobal), a centre supported by "la Caixa" Foundation.

10 Jan 2025

T cells can completely prevent viral infections in humans

Scientists from Duke-NUS Medical School and the Singapore General Hospital have discovered that T cells-white blood cells that can destroy harmful pathogens-can completely prevent viral infection, to an extent previously thought only possible due to neutralizing antibodies.

10 Jan 2025

Machine learning reveals why cancer trials fall short in real-world patients

TrialTranslator uses machine learning to assess cancer RCT generalizability, revealing survival gaps for high-risk patients and enhancing research accuracy.

10 Jan 2025

Clinical Trial News and Research

New research identifies key subtype of bacterial vaginosis that increases chlamydia risk

T-DM1 reduces long-term risk of death in HER2-positive breast cancer patients

CGM data offers superior insights into diabetes complications

Xenon gas offers potential neuroprotective effects for Alzheimer's patients

Antihistamine shows promise for treating rare genetic liver disease

Pheno Therapeutics receives clinical trial authorization for novel multiple sclerosis therapeutic

Groundbreaking trial finds levofloxacin effective against multidrug-resistant TB

PIN1 protein found to be a significant driver of bladder cancer

Lifestyle support shows promise in reducing chronic back pain disability

Pheno Therapeutics granted clinical trial authorization for lead multiple sclerosis therapeutic candidate PTD802

CAR-NK cells offer safer, more accessible treatment for lymphoma

No short-term benefit found for PCT-guided antibiotic treatment in children

New drug cocktail enhances CAR-T cells for cancer treatment

Research highlights changing trends in ADHD diagnoses among adolescents and adults

Study reveals route of entry for Semliki Forest virus into the brain

Boston Scientific announces agreement to acquire Bolt Medical, Inc.

UTHealth project aims to improve clinical trials for underserved people with neurological conditions

Innovative tablet combination shows promise in fighting Trichuris trichiura and other helminths

T cells can completely prevent viral infections in humans

Machine learning reveals why cancer trials fall short in real-world patients

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