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New drug strategy reverses resistance to immunotherapy in pancreatic cancer

A new drug strategy that regulates the tumor immune microenvironment may transform a tumor that resists immunotherapy into a susceptible one, according to a study by researchers from the Johns Hopkins Kimmel Cancer Center and Oregon Health & Science University.

14 Nov 2024

Phase 3 study finds inebilizumab effective for immunoglobulin G4–related disease

An international, phase 3 clinical trial led by investigators at Mass General Brigham could improve the treatment of a rare disease that can cause debilitating symptoms.

14 Nov 2024

Teledermoscopy offers reliable skin cancer diagnosis

Collecting images of suspicious-looking skin growths and sending them off-site for specialists to analyze is as accurate in identifying skin cancers as having a dermatologist examine them in person, a new study shows.

14 Nov 2024

Zambia study finds limited impact of financial support on teenage pregnancies

Many young girls in low- and middle-income countries become pregnant early, which can be dangerous for them and for their babies.

14 Nov 2024

New vaccine shows potential in preventing recurrence of triple-negative breast cancer

A small clinical trial shows promising results for patients with triple-negative breast cancer who received an investigational vaccine designed to prevent recurrence of tumors.

14 Nov 2024

FasL inhibitor speeds recovery and reduces mortality in severe COVID-19 patients

A new clinical study shows that an inhibitor of Fas ligand (FasL), also called CD95 ligand (CD95L), led to a faster recovery of COVID-19 patients and reduced mortality.

14 Nov 2024

Self-reported symptom screening reduces symptom burden in pediatric cancer patients

Regular, self-reported symptom screening was associated with reduced symptom burden when compared with usual care for pediatric patients with cancer, according to new research led by scientists at the University of Toronto and The Hospital for Sick Children (SickKids).

14 Nov 2024

MRI-guided SBRT reduces side effects in prostate cancer treatment

After a comprehensive two-year follow-up, researchers at the UCLA Health Jonsson Comprehensive Cancer Center found that MRI-guided stereotactic body radiotherapy (SBRT) for prostate cancer significantly reduced long-term side effects and improved quality of life, particularly in bowel and sexual health, compared to conventional CT-guided treatment.

14 Nov 2024

UAB researchers reverse liver disease in mice with gene therapy

UAB researchers have reversed metabolic dysfunction-associated steatohepatitis (MASH) in mouse models. MASH is a severe liver disease associated with obesity and type 2 diabetes that affects more than 40 million people.

13 Nov 2024

HEPA air purifiers fall short in cutting respiratory infections in aged-care facilities

Research on HEPA-14 air purifiers in aged care reveals no significant impact on respiratory infections, though initial phase results suggest potential benefits.

13 Nov 2024

Study suggests beta-blockers may elevate depression symptoms in post-MI patients

In MI patients with preserved heart function, beta-blockers are linked to higher depressive symptoms, indicating a need for careful mental health assessment.

13 Nov 2024

Study uncovers why white button mushrooms may help prevent prostate cancer progression

Researchers at City of Hope, one of the largest and most advanced cancer research and treatment organizations in the United States, ranked among the nation's top 5 cancer centers by U.S. News & World Report and a national leader in providing cancer patients with best-in-class, integrated supportive care programs, now understand why taking an investigational white button mushroom supplement shows promise in slowing and even preventing prostate cancer from spreading among men who joined a phase 2 clinical trial studying "food as medicine."

12 Nov 2024

Study shows community health workers can improve asthma care for children

While great strides have been made to ensure children have access to proper asthma care in their home and community, linking those environments to the care that children receive while in school has been a challenge.

12 Nov 2024

MUSC team develops digital toolkit to screen for intimate partner violence and PTSD in opioid use disorder

The opioid crisis has left an estimated 2.5 million people 18 and older in the U.S. with opioid use disorder, or OUD. Despite increased attention to the heavy toll taken by OUD, key risk factors such as intimate partner violence (IPV) and post-traumatic stress disorder (PTSD) are often overlooked. Both increase the risk of OUD and complicate recovery efforts.

12 Nov 2024

Early genomic profiling improves cancer treatment outcomes

New real-world data from Providence, Illumina, and Microsoft Research reveals that Comprehensive Genomic Profiling (CGP), when done early in a cancer patient's diagnosis, leads to better personalized treatment and patient outcomes.

12 Nov 2024

New treatment combination improves outcomes for small cell bladder and prostate cancer patients

A research team led by UCLA Health Jonsson Comprehensive Cancer Center investigators has shown that that combining pembrolizumab, an immunotherapy drug, with standard chemotherapy can improve treatment outcomes for patients with small cell bladder cancer and small cell/neuroendocrine prostate cancer.

12 Nov 2024

Cannabinol enhances sleep in rats, study shows

Research by scientists at the University of Sydney has identified a constituent in the cannabis plant that improves sleep.

11 Nov 2024

Early RSV vaccination in pregnancy provides best protection for newborns

Current guidelines recommend that pregnant people receive a vaccine against respiratory syncytial virus (RSV) - which typically causes mild, cold-like symptoms in most adults but can be deadly for infants - during weeks 32–36 of pregnancy.

11 Nov 2024

VANCE trial marks milestone in t cell therapy for solid tumors

The largest ever clinical trial of T cell therapy for solid tumors has ended, heralding a new era for precision T cell therapy.

11 Nov 2024

GLP-1 and SGLT2 inhibitors show promise in preventing recurrent stroke and heart attack

GLP-1 receptor agonists and SGLT2 inhibitors, two classes of medications most commonly prescribed to treat Type 2 diabetes or weight loss, may reduce the risk of heart attack, second strokes and death in adults who had an initial stroke, according to a preliminary study to be presented at the American Heart Association's Scientific Sessions 2024.

11 Nov 2024

Clinical Trial News and Research

New drug strategy reverses resistance to immunotherapy in pancreatic cancer

Phase 3 study finds inebilizumab effective for immunoglobulin G4–related disease

Teledermoscopy offers reliable skin cancer diagnosis

Zambia study finds limited impact of financial support on teenage pregnancies

New vaccine shows potential in preventing recurrence of triple-negative breast cancer

FasL inhibitor speeds recovery and reduces mortality in severe COVID-19 patients

Self-reported symptom screening reduces symptom burden in pediatric cancer patients

MRI-guided SBRT reduces side effects in prostate cancer treatment

UAB researchers reverse liver disease in mice with gene therapy

HEPA air purifiers fall short in cutting respiratory infections in aged-care facilities

Study suggests beta-blockers may elevate depression symptoms in post-MI patients

Study uncovers why white button mushrooms may help prevent prostate cancer progression

Study shows community health workers can improve asthma care for children

MUSC team develops digital toolkit to screen for intimate partner violence and PTSD in opioid use disorder

Early genomic profiling improves cancer treatment outcomes

New treatment combination improves outcomes for small cell bladder and prostate cancer patients

Cannabinol enhances sleep in rats, study shows

Early RSV vaccination in pregnancy provides best protection for newborns

VANCE trial marks milestone in t cell therapy for solid tumors

GLP-1 and SGLT2 inhibitors show promise in preventing recurrent stroke and heart attack

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