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Scientists discover key component to repair the molecular motor of human heart

A team of scientists from Loyola University Chicago's Stritch School of Medicine have discovered a critical component for renewing the heart's molecular motor, which breaks down in heart failure.

20 May 2021

Blocking TGFβ1 could improve hematopoiesis in AML patients, indicates study

Bone marrow failure due to acute myeloid leukemia (AML) is a significant factor behind the disease's high rate of morbidity and mortality. Previous studies in mice suggest that AML cells inhibit healthy hematopoietic (blood) stem and progenitor cells (HSPC).

20 May 2021

New peptides allow cannabis-derived drugs to fight pain in mice without side effects

An international team, led by researchers from Pompeu Fabra University (UPF) in Barcelona, Spain, David Andreu and Rafael Maldonado, has developed a peptides family that allows delta-9-tetrahydrocannabinol (THC), the main component of Cannabis sativa, to fight pain in mice without side effects.

20 May 2021

Dupilumab considerably reduced asthma exacerbations in young children, shows VOYAGE trial

Results from the VOYAGE study of dupilumab (Dupixent) showed that the monoclonal antibody significantly reduced exacerbations in children ages 6-11 with uncontrolled moderate-to-severe asthma, compared to placebo, according to research presented at the ATS 2021 International Conference. VOYAGE (NCT02948959) is a recently completed randomized, placebo-controlled double-blind multicenter phase 3 clinical trial, that took place in a number of countries.

20 May 2021

Phase 3 trial: New biologic therapy improves outcomes in adults, adolescents with severe asthma

Results from the NAVIGATOR study of tezepelumab showed that the new biologic therapy significantly reduced exacerbations requiring hospital stays and emergency department (ED) visits for adults and adolescents with severe, uncontrolled asthma, according to research presented at the ATS 2021 International Conference.

20 May 2021

Tobacco smoke exposure in utero and during early childhood can affect children's lung function

Environmental tobacco smoke exposure in utero and during early childhood - especially secondhand smoke - is associated with decreased childhood lung function, according to research presented at the ATS 2021 International Conference.

20 May 2021

About two-fifths of Medicare beneficiaries with COPD have limited access to pulmonary rehabilitation services

Approximately two-fifths of Medicare beneficiaries with chronic obstructive pulmonary disease (COPD) have limited access to pulmonary rehabilitation services due to their distance from rehab centers, according to research presented at the ATS 2021 International Conference.

20 May 2021

Blocking ABCB10 protein in liver cells protects against high blood sugar, fatty liver disease

A new multi-institution study led by a team of researchers at the David Geffen School of Medicine demonstrated that blocking a protein called ABCB10 in liver cells protects against high blood sugar and fatty liver disease in obese mice.

20 May 2021

Seed money: Black entrepreneurs hope pandemic gardening boom will grow healthier eating

Ietef Vita had planned to spend most of 2020 on the road, promoting "Biomimicz," the album the rapper had released on his #plantbasedrecords label in January.

20 May 2021

Are COVID-19-related complications in children explained by abnormal immune responses?

A common theme in reports on COVID-19 around the world has been the large number of children who have not been infected or shown signs of disease. However, though the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes less acute infection in this age group, it is associated with a severe immune-mediated multisystemic illness called multisystem inflammatory syndrome in children (MIS-C).

20 May 2021

Early treatment may prevent clotting in COVID-19 vaccine-related thrombocytopenia

Now, a new report in the Journal of Thrombosis and Hemostasis reveals that timely diagnosis and treatment of this condition may prevent further morbidity and mortality, and enable the vaccine to be used widely with confidence.

20 May 2021

Plant-produced COVID-19 vaccine shows potent immunogenic profile in humans

An interim report on a phase 2 clinical trial indicates both the safety and efficacy of a plant-produced virus-like particle vaccine candidate against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The vaccine candidate has shown an acceptable safety profile and high potency in inducing humoral and cellular immune responses in adults (18 – 64 years) and elderly (65 years and above) individuals. The report is currently available on the medRxiv* preprint server.

20 May 2021

UB pharmacy researcher to design real-time algorithm to reduce hospital readmission rates for COPD patients

To lower hospital readmission rates for patients with chronic obstructive pulmonary disease (COPD), University at Buffalo pharmacy researcher David Jacobs has received a $962,000 award from the National Heart, Lung, and Blood Institute to develop a real-time readmission risk prediction algorithm.

20 May 2021

A better understanding of brain fluid movements can help predict and treat Alzheimer's disease

Scientists don't fully understand what causes Alzheimer's disease, but they have a primary suspect.

20 May 2021

Study could serve as guidepost for developing new therapies for Alzheimer's disease

In a major breakthrough, researchers at Massachusetts General Hospital (MGH) have discovered how amyloid beta--the neurotoxin believed to be at the root of Alzheimer's disease (AD)--forms in axons and related structures that connect neurons in the brain, where it causes the most damage.

20 May 2021

Philly CEAL team receives NIH grant to extend COVID-19 outreach

José A. Bauermeister, PhD, and Antonia M. Villarruel, PhD, are leading one of 10 new research teams from across the country that received National Institutes of Health (NIH) grants totaling $14 million to extend the reach of the NIH's Community Engagement Alliance (CEAL) Against COVID-19 Disparities.

20 May 2021

Monoclonal antibody bamlanivimab reduces hospitalization and death in moderate-to-severe COVID-19

Researchers at the University of Pittsburgh School of Medicine and the University of Pittsburgh Medical Center found that monoclonal antibodies, a COVID-19 treatment administered early after infection, reduce the risk of hospitalization and death by 60 percent in people at high risk of suffering complications from the condition.

20 May 2021

Human monoclonal antibodies neutralize SARS-CoV-2 in an Fc-independent manner

Researchers from Israel recently isolated a set of SARS-CoV-2 neutralizing monoclonal antibodies from blood samples of patients with severe COVID-19. They were the first to show that transgenic K18-hACE2 mice infected with lethal doses of SARS-CoV-2 can be fully protected by administering antibodies even 3 days after infection

19 May 2021

Potential immunotherapy may improve cognitive and behavioral functions after stroke

Specialized immune cells that accumulate in the brain in the days and weeks after a stroke promote neural functions in mice, pointing to a potential immunotherapy that may boost recovery after the acute injury is over, University of Pittsburgh School of Medicine neurologists found.

19 May 2021

Cognitive, behavioral therapy may produce more significant outcomes for obese people

Quality of life relating to physical and mental health can be a key element in the treatment of obese adults.

19 May 2021

Blood News and Research

Scientists discover key component to repair the molecular motor of human heart

Blocking TGFβ1 could improve hematopoiesis in AML patients, indicates study

New peptides allow cannabis-derived drugs to fight pain in mice without side effects

Dupilumab considerably reduced asthma exacerbations in young children, shows VOYAGE trial

Phase 3 trial: New biologic therapy improves outcomes in adults, adolescents with severe asthma

Tobacco smoke exposure in utero and during early childhood can affect children's lung function

About two-fifths of Medicare beneficiaries with COPD have limited access to pulmonary rehabilitation services

Blocking ABCB10 protein in liver cells protects against high blood sugar, fatty liver disease

Seed money: Black entrepreneurs hope pandemic gardening boom will grow healthier eating

Are COVID-19-related complications in children explained by abnormal immune responses?

Early treatment may prevent clotting in COVID-19 vaccine-related thrombocytopenia

Plant-produced COVID-19 vaccine shows potent immunogenic profile in humans

UB pharmacy researcher to design real-time algorithm to reduce hospital readmission rates for COPD patients

A better understanding of brain fluid movements can help predict and treat Alzheimer's disease

Study could serve as guidepost for developing new therapies for Alzheimer's disease

Philly CEAL team receives NIH grant to extend COVID-19 outreach

Monoclonal antibody bamlanivimab reduces hospitalization and death in moderate-to-severe COVID-19

Human monoclonal antibodies neutralize SARS-CoV-2 in an Fc-independent manner

Potential immunotherapy may improve cognitive and behavioral functions after stroke

Cognitive, behavioral therapy may produce more significant outcomes for obese people

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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