Ductal Carcinoma in Situ (DCIS) News and Research

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Ductal Carcinoma in Situ (DCIS) is a condition where the cells lining the milk ducts (the channels in the breast that carry milk to the nipple) are cancerous, but stay contained within the ducts without growing through into the surrounding breast tissue. DCIS may affect just one area of the breast, but can be more widespread and affect different areas at the same time. Sometimes DCIS may be described as pre-cancerous, pre-invasive, non-invasive, or intraductal cancer.

New fluorescent tool tracks cancer cell movement in real time

Cancer cell movement during metastasis is a dynamic process regulated by several different signals. However, the way cells receive, process and respond to these signals has been extremely hard to detect, but is now made easier by a new visualisation tool.

2 Jun 2025

Late motherhood and weight gain greatly increase breast cancer risk

Women who experience significant weight gain after the age of 20 and either have their first child after the age of 30 or don't have children are almost three times more likely to develop breast cancer than those who give birth earlier and whose weight remains relatively stable, new research from the UK being presented at this year's European Congress on Obesity (ECO 2025) has found.

11 May 2025

UC San Diego researchers discover new way to predict breast cancer spread

By assessing how "sticky" tumor cells are, researchers at the University of California San Diego have found a potential way to predict whether a patient's early-stage breast cancer is likely to spread.

5 Mar 2025

AI boosts breast cancer detection rates while cutting radiologist workload

AI-supported mammography screening significantly increases breast cancer detection rates while maintaining comparable recall rates, offering a safer and more efficient solution to address radiologist workloads.

8 Jan 2025

Active monitoring for low-risk DCIS results in similar quality of life as standard treatment

Patients with low-risk ductal carcinoma in situ (DCIS) who underwent active monitoring reported comparable physical, emotional, and psychological outcomes to patients who received upfront treatment, according to results from the COMET clinical trial presented at the San Antonio Breast Cancer Symposium (SABCS), held December 10-13, 2024.

12 Dec 2024

COMET trial shows active monitoring is noninferior to standard treatment for low-risk DCIS

Among patients with hormone receptor (HR)-positive, HER2-negative, low-risk ductal carcinoma in situ (DCIS), those who underwent active monitoring had similar two-year invasive ipsilateral breast cancer recurrence rates as those who underwent guideline-concordant treatment, according to results from the COMET clinical trial presented at the San Antonio Breast Cancer Symposium (SABCS), held December 10-13, 2024.

12 Dec 2024

Tamoxifen lowers breast cancer recurrence in good-risk DCIS patients

For patients with "good-risk" ductal carcinoma in situ (DCIS) who underwent breast- conserving surgery and did not receive radiotherapy, tamoxifen significantly decreased the risk of recurrence in the same breast, according to results presented at the San Antonio Breast Cancer Symposium (SABCS), held December 10-13, 2024.

12 Dec 2024

Normal breast tissue cells harbor cancer-like genetic abnormalities

A new study from researchers at The University of Texas MD Anderson Cancer Center finds that, in healthy women, some breast cells that otherwise appear normal may contain chromosome abnormalities typically associated with invasive breast cancer. The findings question conventional thinking on the genetic origins of breast cancer, which could influence early cancer detection methods.

20 Nov 2024

Researchers uncover key genes linked to DCIS progression

A team of researchers mapping a molecular atlas for ductal carcinoma in situ (DCIS) has made a major advance toward distinguishing whether the early pre-cancers in the breast will develop into invasive cancers or remain stable.

20 Nov 2024

10-year study shows DBT outperforms 2D mammography in breast cancer detection

According to a new 10-year study, screening for breast cancer with digital breast tomosynthesis (DBT) increases cancer detection rates and significantly reduces the rate of advanced cancers compared to conventional 2D digital mammography.

17 Sep 2024

AI model enhances DCIS diagnosis using tissue image analysis

Ductal carcinoma in situ (DCIS) is a type of preinvasive tumor that sometimes progresses to a highly deadly form of breast cancer. It accounts for about 25 percent of all breast cancer diagnoses.

24 Jul 2024

AI improves breast cancer screening performance and reduces false-positives

Using artificial intelligence (AI), breast radiologists in Denmark have improved breast cancer screening performance and reduced the rate of false-positive findings. Results of the study were published today in Radiology, a journal of the Radiological Society of North America (RSNA).

4 Jun 2024

Study finds women with DCIS diagnosed outside NHS screening face fourfold increase in breast cancer mortality

Researchers compared the risks of aggressive breast cancers and mortality following DCIS undetected during screening in the general public to those identified through the NHS breast screening program.

29 Jan 2024

Missing NHS screenings linked to significantly higher breast cancer risk

Women who are diagnosed with ductal carcinoma in situ (DCIS) outside the NHS breast screening programme are around four times as likely to develop invasive breast cancer and to die from breast cancer than women in the general population, finds a study published by The BMJ today.

24 Jan 2024

Low-risk DCIS patients may safely skip radiotherapy after surgery, study finds

Patients with low-risk ductal carcinoma in situ (DCIS) who skipped adjuvant radiotherapy after breast-conserving surgery had comparable five-year outcomes to those with high-risk DCIS who received adjuvant radiotherapy, according to results from the E4112 clinical trial presented at the San Antonio Breast Cancer Symposium, held December 5-9, 2023.

8 Dec 2023

AI model accurately predicts breast cancer risk across multiple races

A deep learning artificial intelligence (AI) model that was developed using only mammogram image biomarkers accurately predicted both ductal carcinoma in situ (DCIS) and invasive carcinoma, according to research being presented today at the annual meeting of the Radiological Society of North America.

29 Nov 2023

Researchers develop gene classifier to predict DCIS risk of cancer progression

20 Nov 2023

Air pollution fueling a spike in breast cancer risk

New study finds that exposure to PM2.5 air pollution increases the risk of breast cancer in women by 8% for each 10 µg/m3 increase. The groundbreaking research is the first to provide concrete evidence linking fine particulate matter to ER+ breast cancer.

13 Sep 2023

Healthy breast fat may protect against invasive breast cancer

Researchers have found a possible explanation as to why higher breast density and older age increase the risk of breast cancer.

17 Jul 2023

Addressing long-standing issue in women's health: Lumps in the breast

A new research perspective was published in Oncotarget's Volume 14 on April 24, 2023, entitled, "Crossroads: the role of biomarkers in the management of lumps in the breast."

3 May 2023