Electrophysiology News and Research

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Maladaptive brain-state locking framework redefines chronic brain disorders

Neurodevelopmental, psychiatric, and neurodegenerative disorders are traditionally studied separately yet show overlapping disturbances in neural regulation and resilience.

21 Oct 2026

New scientific statement urges doctors to prescribe exercise for heart health

Exercise should be prescribed as a foundational component of cardiovascular disease (CVD) prevention and treatment, according to a new American College of Cardiology Scientific Statement published today in JACC, its flagship journal.

15 Oct 2026

County analysis reveals deep geographic and racial heart disease disparities

Despite sustained declines in overall cardiovascular disease mortality in the U.S., disparities based on race, ethnicity and place still persist, with mortality varying far more across counties than states, according to a county-by-cause-by-population analysis published in JACC, the flagship journal of the American College of Cardiology (ACC).

7 Oct 2026

New brain circuit discovery offers hope for panic disorder treatments

Our survival depends on brains that constantly search for danger and, if found, stay alert until it has passed.

21 Sep 2026

Strength training shows no added arrhythmia risk in people with arrhythmogenic cardiomyopathy

People living with arrhythmogenic cardiomyopathy (ACM), a heritable heart condition that can significantly increase risks for sudden cardiac death, are advised to avoid high-intensity aerobic exercise.

10 Sep 2026

Study reveals structure of color-sensing cone cells in primates

For over 60 years, scientists have debated a basic structural question about cone photoreceptors, the cells that let vertebrates see color: are their light-sensing disk membranes closed off inside the cell, or are they open to the extracellular space? In non-mammalian species, the answer is clear - cone disk membranes typically stay continuous with the surrounding plasma membrane and are therefore open.

10 Sep 2026

Technological roadmap proposed for lifetime brain-wide neural recordings

Understanding the brain requires tools that can follow neural activity across many scales: from millisecond electrical spikes in individual neurons to brain-wide circuit dynamics that change over months, years, and even a lifetime.

9 Sep 2026

Inhibitory neurons act as a brake on brain tumor growth

Brain tumors do not grow in isolation. They develop within the highly active environment of the brain, where neurons continuously exchange electrical and chemical signals.

7 Sep 2026

Psilocybin protects sensory nerves from chemotherapy damage in preclinical study

In mouse models, prophylactic psilocybin prevented or reduced multiple features of chemotherapy-induced peripheral neuropathy, with cycle-matched dosing sustaining protection during repeated cisplatin exposure without measurably affecting tumor growth. Experiments in human-derived sensory neurons and ex vivo peripheral nerves linked the effect to 5-HT2A-dependent preservation of mitochondrial trafficking and local axonal energy supply, while a nonhallucinogenic 5-HT2A agonist reproduced protection against mechanical hypersensitivity.

6 Sep 2026

Too little or too much testosterone may matter for heart rhythm

A review of clinical trials, observational studies, genetic analyses, and mechanistic research suggests that atrial fibrillation risk may follow a U-shaped relationship with testosterone, increasing at both low and high levels. Evidence on testosterone replacement therapy remains mixed, with researchers calling for prospective studies to determine whether mid-physiological testosterone targets and treatment formulation influence AF risk.

2 Sep 2026

Adolescent binge drinking causes lasting changes in brain function

New research from the Marshall University Joan C. Edwards School of Medicine provides insight into how binge alcohol exposure during adolescence may cause lasting changes in brain function that persist into adulthood, potentially identifying a new target for future treatment approaches.

1 Sep 2026

Study shows how temperature extremes can contribute to heart failure hospitalizations

Heart failure hospitalization risk increases after short-term exposure to cold spells, lower ambient temperatures and higher ambient temperatures, according to a study published in JACC, the flagship journal of the American College of Cardiology, and simultaneously presented at ESC Congress 2026.

28 Aug 2026

Wake-activated brain circuits reveal what drives the urge to sleep

Researchers identified wake-activated neurons in the median raphe and anterior medial preoptic area that track sleep pressure and help regulate when and how deeply mice sleep. Manipulating these circuits altered NREM sleep, sleep-pressure accumulation, and rebound sleep, revealing key neural mechanisms underlying mammalian sleep homeostasis.

20 Aug 2026

Intracranial local field potentials offer clues to prolonged disorders of consciousness

Prolonged disorders of consciousness (pDOC) represent states in which patients fail to show reliable evidence of awareness after severe brain injury.

16 Aug 2026

Waist size predicts heart disease risk better than body mass index

The size of a person's midsection is a better indicator of cardiovascular disease risk when compared to their body mass index (BMI) alone, according to a study published in JACC, the flagship journal of the American College of Cardiology.

11 Aug 2026

Early-life stress rewires brain epigenetics to heighten sensitivity to future stress

. Early-life stress increased SETD7 and H3K4me1 in the ventral tegmental area of mice, creating an epigenetically primed state that heightened later transcriptional, neuronal, and behavioral responses to stress. Reducing Setd7 during development lowered H3K4me1 and weakened these stress-sensitizing effects, identifying a mechanism that may help explain how early adversity leaves lasting biological effects.

11 Aug 2026

Scientific statement reframes cardiovascular care for older patients with cognitive impairment and frailty

Older adults with cardiovascular disease (CVD) often have coexisting cognitive impairment and frailty, conditions that can significantly affect treatment decisions, recovery, independence and quality of life and should be considered as part of an aging-informed approach to care, according to a new American College of Cardiology Scientific Statement published in JACC, the flagship journal of the ACC.

10 Aug 2026

Physical activity linked to lower stroke and death risk in adults with atrial fibrillation

Being physically active was linked to a lower risk of stroke and death for adults with atrial fibrillation, or AFib, according to new, independent research published today in the Journal of the American Heart Association, an open access, peer-reviewed journal of the American Heart Association.

5 Aug 2026

Blood filtration method helps clear circulating lipids and toxic microplastics

The machine is not new. Some version of it has run in hospital treatment rooms for about four decades, drawing blood from one arm, separating out the plasma, passing it across a filter or an adsorber, and returning it to the other arm.

4 Aug 2026

AI-powered analytics and experimental validation: Transforming target identification in drug discovery

Discover how AI-powered analytics and experimental validation combine to improve target identification and accelerate drug discovery success.

From Axxam S.p.A 23 Jul 2026