ACE2 News and Research

RSS

D614G mutation promotes lysosomal trafficking of SARS-CoV-2 spike protein

In the current COVID-19 pandemic, SARS-CoV-2 has led to millions of infections worldwide, with over 1.5 million deaths.

14 Dec 2020

Distant residues modulate the conformational opening in SARS-CoV-2 spike protein

Scientists present an insight into the RBD dynamics with physically distant residues in the spike protein, elaborating on the importance of predicted mutations for therapeutics.

11 Dec 2020

Study shows how coronavirus uses spike proteins to infiltrate cells of different animals

Humans, followed by ferrets and to a lesser extent cats, civets and dogs are the most susceptible animals to SARS-CoV-2 infection, according to an analysis of ten different species carried out by researchers at the Centre for Genomic Regulation (CRG), based in Barcelona.

11 Dec 2020

COVID-19 infection may also affect the central nervous system, cause neurological disorders

COVID-19 is known primarily as a respiratory disease, with symptoms that include cough, shortness of breath, and, in severe cases, acute respiratory distress syndrome and pneumonia

10 Dec 2020

SARS-CoV-2 spike protein mediates acute lung pathology in mice

A study shows that the viral spike protein is adequate by itself to induce macrophage activation in pulmonary tissue and induce acute inflammation.

10 Dec 2020

Different SARS-CoV-2 neutralization assays are reliable and concordant for antibody monitoring

A recent study by US researchers, currently available on the medRxiv preprint server, evaluated several cell-based assays that are under validation for determining correlates of protection in individuals with symptomatic coronavirus disease (COVID-19) and vaccine studies – and demonstrated their high concordance with both live and pseudotyped virions.

9 Dec 2020

The effects of cigarette smoke and COPD on SARS-CoV-2 infection

Researchers have revealed some of the effects of cigarette smoke and chronic obstructive pulmonary disease (COPD) on SARS-CoV-2 infection.

9 Dec 2020

Scientists determine key molecular processes used by coronavirus to infect human cells

When a coronavirus--including SARS-CoV-2, which causes COVID-19--infects someone, it hijacks the person's cells, co-opting their molecular machinery for its own survival and spread.

9 Dec 2020

Researchers assess the binding behavior of SARS-CoV-2 virus

The binding of a SARS-CoV-2 virus surface protein spike -- a projection from the spherical virus particle -- to the human cell surface protein ACE2 is the first step to infection that may lead to COVID-19 disease.

8 Dec 2020

Amilorides reduce SARS-CoV-2 viral replication in vitro

A new U.S. study published on the bioRxiv preprint server reports the use of an amiloride-based scaffold that targets a viral RNA structure known to be essential in viral replication in the 5’-untranslated region (UTR) of the virus. The researchers say this heralds the application of these molecules as chemical probes to explore viral biology and produce specific antivirals targeting RNA regions of the coronavirus genome.

8 Dec 2020

High-performing multi-immunoassay for early diagnosis and prognosis of COVID-19

A new study published on the preprint server bioRxiv in December 2020 indicates the ability of anti-SARS-CoV-2 antibody titers and time of induction to differentiate between severe and mild COVID-19 and could lead to the development of a prognostic biomarker for use early in the course of the illness.

8 Dec 2020

Why is COVID-19 more severe among adults than children?

Researchers in Switzerland and Australia have reviewed some of the mechanisms proposed regarding why coronavirus disease 2019 (COVID-19) is generally less severe among children than among adults.

8 Dec 2020

COVID-19 may be linked to acute appendicitis in children

Researchers at the University of Virginia have recently presented a case series pointing to a potential association between infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the development of acute appendicitis in children.

8 Dec 2020

ACE2 News and Research

D614G mutation promotes lysosomal trafficking of SARS-CoV-2 spike protein

Distant residues modulate the conformational opening in SARS-CoV-2 spike protein

Study shows how coronavirus uses spike proteins to infiltrate cells of different animals

COVID-19 infection may also affect the central nervous system, cause neurological disorders

SARS-CoV-2 spike protein mediates acute lung pathology in mice

Different SARS-CoV-2 neutralization assays are reliable and concordant for antibody monitoring

The effects of cigarette smoke and COPD on SARS-CoV-2 infection

Scientists determine key molecular processes used by coronavirus to infect human cells

Researchers assess the binding behavior of SARS-CoV-2 virus

Amilorides reduce SARS-CoV-2 viral replication in vitro

High-performing multi-immunoassay for early diagnosis and prognosis of COVID-19

Why is COVID-19 more severe among adults than children?

COVID-19 may be linked to acute appendicitis in children

Bioactive tea compounds show potential anti-SARS-CoV-2 activity

Mice study shows how COVID-19 damages organs other than the lungs

Antibody responses to SARS-CoV-2 virus disappear quickly during convalescence, indicates study

D614/G614 variants of SARS-CoV-2 affect neuronal transmission; G614 better at membrane fusion

STE90-C11, a SARS-CoV-2 neutralizing antibody, shows high inhibition of RBD-ACE2 binding

Novel modular design approach to antibody nanocage generation

Topoisomerase 1 inhibition prevents SARS-CoV-2-induced inflammation and death in animal models

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

Latest News