Alzheimer's Disease News and Research

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Alzheimer's disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks of daily living. In most people with AD, symptoms first appear after age 60. AD is the most common cause of dementia among older people, but it is not a normal part of aging. Dementia refers to a decline in cognitive function that interferes with daily life and activities. AD starts in a region of the brain that affects recent memory, then gradually spreads to other parts of the brain. Although treatment can slow the progression of AD and help manage its symptoms in some people, currently there is no cure for this devastating disease.

New common pathway in neurodegenerative disease is a possible door to a point of no return

A just-out study suggests that what keeps chronic nervous system diseases such as Alzheimer's, Huntington's and ALS going - until they overcome the internal protective mechanisms a body can throw at them - may largely come down to poor conversational skills.

9 Apr 2009

Rogue Alzheimer's gene causes early brain changes

British scientists have found that some young adults who carry a certain genetic variant have an increased risk of developing Alzheimer's disease and distinct brain patterns and changes in their brain activity started decades before any symptoms appeared.

8 Apr 2009

Young adults at future risk of Alzheimer's have different brain activity

Young adults with a genetic variant that raises their risk of developing Alzheimer's Disease show changes in their brain activity decades before any symptoms might arise, according to a new brain imaging study by scientists from the University of Oxford and Imperial College London.

6 Apr 2009

Researchers regenerate axons necessary for voluntary movement

For the first time, researchers have clearly shown regeneration of a critical type of nerve fiber that travels between the brain and the spinal cord and which is required for voluntary movement.

6 Apr 2009

Alzheimer's disease linked to mitochondrial damage

Investigators at the Burnham Institute for Medical Research (Burnham) have demonstrated that attacks on the mitochondrial protein Drp1 by the free radical nitric oxide-which causes a chemical reaction called S-nitrosylation-mediates neurodegeneration associated with Alzheimer's disease.

5 Apr 2009

Better tests needed to pinpoint memory problems

There's a lot more to memory than the ability to remember a story, who the President is, or what you ate for lunch.

2 Apr 2009

Activation of the prefrontal cortex improves working memory

Psychologists and neurologists invest considerable effort in the study of working memory.

1 Apr 2009

By shutting down inflammation, agent reverses damage from spinal cord injury in preclinical studies

Researchers at Georgetown University Medical Center (GUMC) have been able to speed recovery and substantially reduce damage resulting from spinal cord injury in preclinical studies.

1 Apr 2009

Senate measure would allow generic versions of biotechnology drugs after five years

Sens. Charles Schumer (D-N.Y.) and Susan Collins (R-Maine) on Thursday introduced legislation (S 726) that would allow FDA to approve generic versions of biotechnology drugs after a five-year period of brand-name patent exclusivity, the New York Times reports.

30 Mar 2009

Discovery of mechanism of neurodegeneration in Alzheimer's disease

Tiny, toxic protein particles severely disrupt neurotransmission and inhibit delivery of key proteins in Alzheimer's disease, two separate studies by Marine Biological Laboratory (MBL) researchers have found.

29 Mar 2009

Salk Institute forms strategic alliance agreement with sanofi-aventis

The Salk Institute has announced that it has signed a strategic alliance agreement with sanofi-aventis, establishing a joint program that supports cutting-edge research and promotes an exchange of discoveries focused on scientific advances and therapeutic applications.

29 Mar 2009

Protein from tick saliva shows potential for myasthenia gravis treatment

Looking for a better treatment for the autoimmune disease myasthenia gravis, researchers have found that a protein in tick saliva shows promise in limiting the severity of the disease in an animal model in a study published in the Annals of Neurology.

29 Mar 2009

New way to make stem cells avoids risk of cancer

A team of scientists has advanced stem cell research by finding a way to endow human skin cells with embryonic stem cell-like properties without inserting potentially problematic new genes into their DNA.

29 Mar 2009

Number of Alzheimer's cases growing annually, increasing costs, report finds

The number of U.S. residents with Alzheimer's disease is increasing annually, putting more pressure on the health care system, according to a report issued on Tuesday by the Alzheimer's Association, USA Today reports (Brophy Marcus, USA Today, 3/24).

25 Mar 2009

New insights may help HIV and cancer patients

Important progress in understanding the function of tetherin, known to have both anti-cancer and anti-viral properties, has been made by researchers at the University of Bristol.

24 Mar 2009

p11 protein may lead to faster acting antidepressants

Research conducted by Nobel laureate Paul Greengard, Medical Director of The Michael Stern Parkinson's Research Center at The Rockefeller University, Dr. Jennifer L. Warner-Schmidt in New York and colleagues in Sweden, demonstrated in the Journal of Neuroscience that the brain protein called p11 could lead pharmaceutical companies to develop anti-depression drugs that begin working within hours or days rather than the weeks or even months required by current drugs.

23 Mar 2009

Thinning of right hemisphere in brain a marker for familial form of depression

Findings from one of the largest-ever imaging studies of depression indicate that a structural difference in the brain - a thinning of the right hemisphere - appears to be linked to a higher risk for depression, according to new research at Columbia University Medical Center and the New York State Psychiatric Institute.

23 Mar 2009

Astrocytes help separate man from mouse

A type of brain cell that was long overlooked by researchers embodies one of very few ways in which the human brain differs fundamentally from that of a mouse or rat, according to researchers who published their findings as the cover story in the March 11 issue of the Journal of Neuroscience.

23 Mar 2009

Researchers step toward a medicine that could actually stop the progress of Alzheimer's

VIB scientists connected to the K.U.Leuven have identified a molecule that can form the basis for a new therapy for Alzheimer's disease.

20 Mar 2009

Cognitive decline can begins in late 20s

A new study indicates that some aspects of peoples' cognitive skills - such as the ability to make rapid comparisons, remember unrelated information and detect relationships - peak at about the age of 22, and then begin a slow decline starting around age 27.

20 Mar 2009