Alzheimer's Disease News and Research

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Alzheimer's disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks of daily living. In most people with AD, symptoms first appear after age 60. AD is the most common cause of dementia among older people, but it is not a normal part of aging. Dementia refers to a decline in cognitive function that interferes with daily life and activities. AD starts in a region of the brain that affects recent memory, then gradually spreads to other parts of the brain. Although treatment can slow the progression of AD and help manage its symptoms in some people, currently there is no cure for this devastating disease.

Alzheimer's mechanism suggests combination therapy needed

Researchers at the University of Illinois at Chicago College of Medicine have discovered a mode of action for mysterious but diagnostic protein snarls found in the brains of Alzheimer's patients that suggests a one-two punch of therapy may be needed to combat the neurodegenerative disease.

17 Mar 2009

A living representation of the brain created by scientists

Researchers in the School of Life & Health Sciences at Aston University in Birmingham, UK are developing a novel new way to model how the human brain works by creating a living representation of the brain.

17 Mar 2009

Shrinking in hippocampus area of brain precedes Alzheimer's disease

People who have lost brain cells in the hippocampus area of the brain are more likely to develop dementia, according to a study published in the March 17, 2009, print issue of Neurology, the medical journal of the American Academy of Neurology.

16 Mar 2009

Scientists 'watch' as individual alpha-synuclein proteins change shape

In an Early Edition publication of The Proceedings of the National Academy of Sciences (PNAS) this week, the researchers demonstrate the "alpha-synuclein dance" - the switching back and forth of the protein between a bent helix and an extended helix as the surface that it is binding to changes.

16 Mar 2009

A biomarker test to diagnose or rule out Alzheimer's disease

A test capable of confirming or ruling out Alzheimer's disease has been validated and standardized by researchers at the University of Pennsylvania School of Medicine.

16 Mar 2009

Alzheimer's disease neuroimaging initiative announces completion of genome-wide analysis

Researchers announced today that a high-density genome wide analysis of participants in the Alzheimer's Disease Neuroimaging Initiative (ADNI; www.adni-info.org) is more than 95% complete and that data will be shared with scientists around the world for further analysis.

16 Mar 2009

Proteomics study shows that genes involved in invertebrate longevity have surprising parallels in humans

Prolexys Pharmaceuticals has announced the publication of the discovery of genes that are likely to have a role in the aging process of humans.

15 Mar 2009

Potential pathway for drug intervention

A newly identified molecular pathway that directs stem cells to produce glial cells yields insights into the neurobiology of Down's syndrome and a number of central nervous system disorders characterized by too many glial cells, according to a recent study by researchers at the Salk Institute for Biological Studies.

15 Mar 2009

Alzheimer's disease therapeutic prevents long-term damage from TBI in pre-clinical studies

A class of Alzheimer's disease drugs currently studied in clinical trials appears to reduce damage caused by traumatic brain injury in animals, researchers at Georgetown University Medical Center report in an upcoming advance online publication of Nature Medicine.

15 Mar 2009

Researchers show how the hippocampus records memory

It may be possible to "read" a person's memories just by looking at brain activity, according to research carried out by Wellcome Trust scientists.

12 Mar 2009

A blood test for Alzheimer's on the horizon

Researchers have revealed a direct relationship between two specific antibodies and the severity of Alzheimer's disease symptoms, raising hopes that a diagnostic blood test for the devastating disorder is within reach.

11 Mar 2009

Anesthesia or hypothermia: Warning for Alzheimer's patients

Everyone knows that its important to keep a cool head, but a new study published online in The FASEB Journal shows that for Alzheimer's patients, a cool head may make the disease worse.

11 Mar 2009

Alzheimer's marker amyloid beta 42 linked to brain damage

Researchers at Washington University School of Medicine in St. Louis have linked a potential indicator of Alzheimer's disease to brain damage in humans with no signs of mental impairment.

11 Mar 2009

Can brain training games help prevent Alzheimer's?

Loss of thinking power is a fear shared by many aging baby boomers.

11 Mar 2009

Brain damage found in cognitively normal people with Alzheimer's marker

Researchers at Washington University School of Medicine in St. Louis have linked a potential indicator of Alzheimer's disease to brain damage in humans with no signs of mental impairment.

11 Mar 2009

Simple balance test may predict cognitive decline in Alzheimer's Disease

A simple balance test may predict cognitive decline in Alzheimer's Disease, according to a study published in the March 2009 issue of the Journal of Alzheimer's Disease.

11 Mar 2009

Metabolic and neurological disorders may share common risk factors

Metabolic disorders such as obesity and diabetes appear to share risk factors with and may influence the development of Alzheimer's disease and other forms of dementia, according to several reports published in the March issue of Archives of Neurology.

10 Mar 2009