Alzheimer's Disease News and Research

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Alzheimer's disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks of daily living. In most people with AD, symptoms first appear after age 60. AD is the most common cause of dementia among older people, but it is not a normal part of aging. Dementia refers to a decline in cognitive function that interferes with daily life and activities. AD starts in a region of the brain that affects recent memory, then gradually spreads to other parts of the brain. Although treatment can slow the progression of AD and help manage its symptoms in some people, currently there is no cure for this devastating disease.

Exercise shown to slow down Alzheimer's progress

According to a new study, patients with the early signs of Alzheimer's disease had less deterioration in the areas of the brain which control memory, if they exercised regularly.

28 Jul 2008

Previous estimates of levels of dementia in the developing world underestimated

Previous estimates of levels of dementia in the developing world may have substantially underestimated the problem, according to research published today. The findings suggest that policymakers in low-income and middle-income countries may need to re-examine the burden and impact that dementia places on their health services.

27 Jul 2008

Physical fitness levels influence brain atrophy in Alzheimer's

People with early Alzheimer's disease who had better fitness ratings had less atrophy in key brain areas associated with memory, according to research reported today at the 2008 Alzheimer's Association International Conference on Alzheimer's Disease (ICAD 2008) in Chicago.

27 Jul 2008

Amyloid plaques seen with conventional MRI in animal model for first time

For the first time, scientists have captured images of brain lesions similar to those found in Alzheimer's disease using clinical-grade MRI in an animal model of the disease, according to research reported at the Alzheimer's Association's 2008 International Conference on Alzheimer's Disease (ICAD 2008), in Chicago.

27 Jul 2008

Researchers find key mechanism of cell damage in aging and disease

Researchers have taken a first snapshot of how a class of highly reactive molecules inflicts cellular damage as part of aging, heart disease, stroke, cancer, diabetes, kidney disease and Alzheimer's disease to name a few. According to a study published today in the journal Cell, researchers have discovered a tool that can monitor related damage and determine the degree to which antioxidant drugs effectively combat disease.

24 Jul 2008

Tethered bilayer membrane may unlock secrets of early-stage Alzheimer's

Researchers at the National Institute of Standards and Technology (NIST) and three collaborating institutions are using a new laboratory model of the membrane surrounding neurons in the brain to study how a protein long suspected of a role in early-stage Alzheimer's disease actually impairs a neuron's structure and function.

23 Jul 2008

Use of rheumatoid arthritis drug to treat Alzheimer's causes concern

New research into the treatment of Alzheimer's disease using a popular rheumatoid arthritis drug has caused some concern.

22 Jul 2008

Dimebon, old hay fever drug shows promise in treating Alzheimer's

Researchers in the U.S. say a drug which was at one time used to treat hay fever "significantly improves" symptoms in patients with mild to moderate Alzheimer's disease.

21 Jul 2008

Potentially new biomarkers for Alzheimer's

Every aging baby boomer listens for the footsteps of Alzheimer's, and for good reason: It's estimated that 10 million American boomers will develop the disease. The need to develop preventative strategies, ideally long before Alzheimer's destructive, clinical symptoms appear, is critical.

19 Jul 2008

Physical activity programs for persons with dementia

Physical activity is a good thing for nearly everybody and clearly boosts alertness and a sense of well-being. So can we use it as a treatment for elderly patients with dementia? That's a good question, but existing research doesn't provide an answer, according to a new Cochrane Library review.

17 Jul 2008

AFFiRiS GmbH alzheimer's vaccine progress

In the clinical phase I trial AFF001, AFFiRiS GmbH has now recruited the 24 Alzheimer patients planned for this trial. The trial aims to investigate the tolerability and safety of an innovative Alzheimer's vaccine (AFFITOPE AD01).

16 Jul 2008

New ways of exploiting medicinal uses of cannabis

Research exploring new ways of exploiting the full medicinal uses of cannabis while avoiding unwanted side-effects will be presented to pharmacologists Tuesday, 15 July by leading scientists attending the Federation of European Pharmacological Societies Congress, EPHAR 2008.

From The University of Manchester 15 Jul 2008

New center for protein therapeutics formed by UB pharmaceutical scientists

Pharmaceutical researchers at the University at Buffalo have joined forces with scientists from several of the world's largest pharmaceutical companies to tackle fundamental research questions that need to be answered to advance development of promising protein-based drugs.

15 Jul 2008

Huntington's disease brain damage linked to overactive immune response in the bloodstream

The damage to brain tissue seen in Huntington's disease may be caused by an overactive immune response in the bloodstream and the brain, according to new findings from two teams of researchers at the University of Washington in Seattle and University College London. The findings will be published online July 14 in the Journal of Experimental Medicine.

14 Jul 2008

Physical exercise may prevent brain shrinkage in early Alzheimer's

Mild Alzheimer's disease patients with higher physical fitness had larger brains compared to mild Alzheimer's patients with lower physical fitness, according to a study published in the July 15, 2008, issue of Neurology, the medical journal of the American Academy of Neurology.

14 Jul 2008

Nicotine clues for dementia treatment

A team of London scientists have found clues for the potentially therapeutic benefits of nicotine on learning, memory and attention while minimising the risk of addiction. The research announced in Geneva Monday will assist the search for new drugs for dementia.

14 Jul 2008

Integrating palliative care for dementia into primary care

Greg A. Sachs, M.D., has received an award from the National Palliative Care Research Center to conduct a study aimed at improving quality of life and decreasing suffering for older adults and their family caregivers. The award is one of only two pilot project support grants funded by NPCRC in 2008.

14 Jul 2008

Novel drug ionophore shows potential for Alzheimer's

Scientists report a remarkable improvement in Alzheimer's transgenic mice following treatment with a new drug. The study, published by Cell Press in the July 10th issue of the journal Neuron, provides the first demonstration that an ionophore, a compound that transports metal ions across cell membranes, can elicit rapid and pronounced improvement in neuropathology and cognitive function in mouse models of Alzheimer's Disease (AD).

10 Jul 2008

Neuron to publish Prana's PBT2 preclinical research on Alzheimer's disease

Prana Biotechnology Ltd. has announced the publication of key research findings with its lead Alzheimer's Disease drug, PBT2.

10 Jul 2008

An analysis of food's affect on the brain

In addition to helping protect us from heart disease and cancer, a balanced diet and regular exercise can also protect the brain and ward off mental disorders.

9 Jul 2008