Aortic Stenosis News and Research

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Physician-assessed aortic stenosis severity correlates with clinical outcomes, study shows

The diagnosed severity of aortic stenosis strongly correlates with clinical outcomes, new Kaiser Permanente research shows.

5 Sep 2023

Can muvalaplin achieve safe and tolerable plasma concentrations adequate to reduce steady-state Lp(a) levels without modulating plasminogen activity in humans?

Researchers evaluated the tolerability, safety, pharmacodynamics, and pharmacokinetic properties of muvalaplin.

30 Aug 2023

TAVR for aortic regurgitation: Moving beyond "off-label" use

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Transcatheter aortic valve replacement (TAVR) is currently a widely used option for patients with severe symptomatic aortic stenosis with high to low surgical risk.

13 Jul 2023

Study sheds light on cause of most common congenital heart defect

Bicuspid aortic valve is the most common congenital defect in humans, affecting between 1% and 2% of the population. Instead of the usual three symmetric leaflets, affected individuals have two asymmetric valve leaflets.

5 Jul 2023

Pilot program lays the groundwork to measure the quality of aortic stenosis care

New research published today in Circulation: Cardiovascular Quality and Outcomes examines the pilot phase of the American Heart Association quality improvement program Target: Aortic Stenosis™.

20 Jun 2023

Large-scale comprehensive sequencing helps downstream medical care in newborns

Researchers who lead the world's first comprehensive sequencing program for newborn infants have published the next chapter in the ongoing study of the BabySeq Project, with new findings on infants and families who have been followed for 3-5 years.

6 Jun 2023

Study reports improved deliverability, tracking, and deployment of next-generation Evolut FX TAVR system

Results from the Evolut FX TAVR (Transcatheter Aortic Valve Replacement) Clinical Survey were presented today as late-breaking clinical research at the Society for Cardiovascular Angiography & Interventions (SCAI) 2023 Scientific Sessions.

19 May 2023

Initial benefit of TAVR remains consistent over the first three years among patients at low surgical risk

The number of deaths and disabling strokes among patients at low surgical risk who were treated with transcatheter aortic valve replacement (TAVR) remained lower at three years, but not significantly lower, following the TAVR procedure compared with patients who received conventional surgical aortic valve replacement (SAVR), according to new data being presented at the American College of Cardiology's Annual Scientific Session Together With the World Congress of Cardiology.

5 Mar 2023

OpSens Announces SavvyWire™ Used During Two Live Cases at CRT Conference

Quebec City, Quebec, February 28, 2023 – OpSens Inc. (“OpSens” or the “Company”) (TSX:OPS) (OTCQX:OPSSF), a medical device cardiology-focused company delivering innovative solutions based on its proprietary optical technology, is pleased to announce the inaugural two SavvyWire live case broadcasts occurred on Monday, February 27, 2023, during the Cardiovascular Research Technologies (CRT) conference.

From OpSens Medical 1 Mar 2023

Custom, 3D-printed robotic heart could help doctors to tailor patient-specific treatments

No two hearts beat alike. The size and shape of the the heart can vary from one person to the next. These differences can be particularly pronounced for people living with heart disease, as their hearts and major vessels work harder to overcome any compromised function.

22 Feb 2023

Morristown Medical Center reaches significant milestone of performing over 4,000 TAVR

Morristown Medical Center's Gagnon Cardiovascular Institute's structural heart program reached a significant milestone of performing over 4,000 transcatheter aortic valve replacement (TAVR) procedures with well over 650 in 2022 alone.

10 Feb 2023

Minimally invasive procedure enables patients to be out of the hospital within a few days

Minimally invasive, catheter-based transcatheter aortic valve replacement (TAVR) has revolutionized treatment of aortic stenosis (AS), and both American and European guidelines have approved its use. However, there is a perception that TAVR is more expensive than surgical aortic valve replacement (SAVR). A budget impact analysis comparing the two options now shows that TAVR is an affordable and effective strategy for the treatment of AS. The study appears in the Canadian Journal of Cardiology, published by Elsevier.

12 Sep 2022

A simple and low-cost method to identify valve dysfunction

Aortic valve stenosis occurs when the aortic valve narrows, constricting blood flow from the heart through the artery and to the entire body.

30 Aug 2022

New risk assessment tool predicts mortality for atrial fibrillation patients after completion of TAVR

A large-scale international study led by Mount Sinai has yielded the first risk score that can help predict mortality for patients with atrial fibrillation (AFib) who have undergone a successful transcatheter aortic valve replacement (TAVR) and discharged home.

29 Aug 2022

Urgent action needed to clear heart surgery backlogs, research suggests

Urgent action is needed to clear the backlog of people with a common heart condition who are waiting for lifesaving treatment, according to research co-led by a Keele Professor.

17 Jun 2022

Early valve replacement surgery could benefit patients with aortic stenosis

Valve replacement heart surgery should be performed earlier than conventionally thought for people with aortic stenosis – according to new research from the University of East Anglia.

18 May 2022

Less invasive procedure for common heart condition just as effective as conventional open-heart surgery

A study led by researchers at the National Institute for Health and Care Research Leicester Biomedical Research Centre has shown that a less invasive heart procedure for a common condition is just as effective as conventional open-heart surgery.

17 May 2022

Calcium supplements may increase risk of death in older people with aortic valve stenosis

Calcium supplements, frequently given to older people to lessen the risk of brittle bones (osteoporosis) and fractures, are linked to a heightened risk of death among those with aortic valve stenosis, a progressive and potentially fatal condition, finds research published online in the journal Heart.

26 Apr 2022

Experimental siRNA therapeutic shows promise to reduce an important driver of heart disease risk

While there are effective therapies to reduce the risk of heart disease by lowering low-density lipoprotein (LDL), or "bad" cholesterol, and other lipids, to date there are no approved treatments to lower lipoprotein(a), a lesser-known driver of heart disease risk.

3 Apr 2022

Experimental siRNA therapy reduces a key driver of heart disease risk by up to 98%

Findings from a new Cleveland Clinic-led phase 1 trial show that an experimental "gene silencing" therapy reduced blood levels of lipoprotein(a), a key driver of heart disease risk, by up to 98%.