Apoptosis News and Research

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Apoptosis is programmed cell death, the body's normal method of disposing of damaged, unwanted, or unneeded cells.

New substance could improve efficacy of established breast cancer treatments

Physicians from Karl Landsteiner University of Health Sciences in Krems (Austria) demonstrate potential for clinical application, collaborating with research groups from Germany, the USA, and China.

13 Dec 2018

Findings may open up new ways to treat dwarfism and other ER-stress-related conditions

Pseudoachondroplasia (PSACH) is a severe inherited dwarfing condition characterized by disproportionate short stature, joint laxity, pain, and early onset osteoarthritis.

12 Dec 2018

Revolutionary new technology sheds light on why cancers form in specific cell types

While many cells in our bodies can accumulate oncogenic mutations, the majority of these events do not lead to tumor formation as these abnormal cells are eliminated by defense mechanisms.

29 Nov 2018

Scientists identify key component of microscopic machinery that drives cell death

An important component of the microscopic machinery that drives cell death has been identified by Walter and Eliza Hall Institute scientists.

27 Nov 2018

Researchers elucidate infection process of bacterial pathogen Clostridium difficile

Scientists from the VIB-UGent Center for Inflammation Research identified the mechanisms by which the bacterial pathogen Clostridium difficile kills intestinal epithelial cells, thus destroying the protective mucosal barrier of the intestinal tract.

21 Nov 2018

Growth and spread of deadly eye tumor suppressed in cells, animals

By comparing genetic sequences in the eye tumors of children whose cancers spread with tumors that didn't spread, Johns Hopkins Medicine researchers report new evidence that a domino effect in cells is responsible for the cancer spreading.

12 Nov 2018

Phase III CLL14 study evaluating Venclexta plus Gazyva to treat CLL meets its primary endpoint

Genentech, a member of the Roche Group , announced today that the randomized Phase III CLL14 study, which evaluated fixed-duration Venclexta® in combination with Gazyva® in people with previously untreated chronic lymphocytic leukemia and co-existing medical conditions, met its primary endpoint and showed a statistically significant reduction in the risk of disease worsening or death compared to standard-of-care Gazyva plus chlorambucil.

1 Nov 2018

Novartis enters into clinical development agreement with Pfizer to improve treatment of NASH

Novartis announced today that it has entered into a clinical development agreement with Pfizer which will include a study combining tropifexor and one or more Pfizer compounds for the treatment of NASH, including an Acetyl CoA-Carboxylase (ACC) Inhibitor (PF-05221304, a Diacylglycerol O-Acyltransferase 2 (DGAT2) Inhibitor (PF-06865571, and a Ketohexokinase (KHK) Inhibitor (PF-06835919).

29 Oct 2018

Newly discovered compound shows potential for treating Parkinson's disease

A joint research group centered around Professor Hideyuki Okano and Associate Professor Jun Kohyama, Department of Physiology of the Keio University School of Medicine, together with a research group of Eisai Co., Ltd. has identified a compound that has the potential to be a treatment for Parkinson's disease by using dopaminergic neurons differentiated from induced pluripotent stem (iPS) cells from patients with familial Parkinson's disease.

19 Oct 2018

New approach to understanding cancers will accelerate development of better treatments

A new innovation in cancer research will enable scientists to understand the complex causes of the disease with unprecedented speed and sophistication. This will accelerate the development of new and better treatments, and it will help researchers find ways around roadblocks that now stand in their path.

19 Oct 2018

Study identifies molecular switch that controls fate of milk-producing breast cells

A research team, led by investigators from Georgetown Lombardi Comprehensive Cancer Center, details how a natural and dramatic process -- changes in mammary glands to accommodate breastfeeding -- uses a molecular process believed to contribute to survival of pre-malignant breast cells.

15 Oct 2018

Natural compound found in grapes may protect against cancer

Lung cancer is the deadliest form of cancer in the world, and 80% of death are related to smoking. In addition to tobacco control, effective chemoprevention strategies are therefore needed.

3 Oct 2018

Aggressive breast cancer hijacks normal protective physiological process to survive

A member of a protein family known for protecting our cells also protects cancer cells in aggressive, metastatic breast cancer, scientists report.

3 Oct 2018

Scientists perform successful trial of new antibiotic on cancer reoccurrence after surgery

SCIENTISTS fighting cancer have carried out the first successful trial of the effects of the antibiotic Doxycycline on cancer reoccurrence in patients after surgery.

3 Oct 2018

Aggressive breast cancer cells hijack protective protein to aid growth

A new study has revealed that a protein known to protect healthy cells also protects cancer cells in aggressive breast cancer.

2 Oct 2018

Why patients with ALL relapse after CAR-T cell therapy

Researchers have made a new discovery about a rare mechanism that triggers the relapse of acute lymphoblastic leukemia (ALL) after CAR T cell therapy.

1 Oct 2018

Why patients with ALL relapse after CAR-T cell therapy

Researchers have made a new discovery about a rare mechanism that triggers the relapse of acute lymphoblastic leukemia (ALL) after CAR T cell therapy.

1 Oct 2018

Researchers decipher antitumor mechanism of Amazonian plant in human cancer cells

A piece of research conducted by the Free Radicals and Oxidative Stress Group at the UPV/EHU's Faculty of Medicine and Nursing has deciphered the antitumor mechanism exerted by the plant Vismia baccifera, originally from the Amazonian region of Colombia, in human liver cancer cells.

28 Sep 2018

Breakthrough observations made possible by label-free long-term 3D imaging of mitochondria

Mitochondria are one of the most (if not the most) important cell organelles. They are organized in extremely dynamic networks and, in addition to supplying the cell with energy, they have an important role in apoptosis, metabolism, and degenerative diseases.

From Nanolive SA 28 Sep 2018

Research reveals how critical oocyte quality control process works

Females are born with a finite number of eggs that are steadily depleted throughout their lifetime. This reserve of eggs is selected from a much larger pool of millions of precursor cells, or oocytes, that form during fetal life.

28 Sep 2018

Apoptosis News and Research

New substance could improve efficacy of established breast cancer treatments

Findings may open up new ways to treat dwarfism and other ER-stress-related conditions

Revolutionary new technology sheds light on why cancers form in specific cell types

Scientists identify key component of microscopic machinery that drives cell death

Researchers elucidate infection process of bacterial pathogen Clostridium difficile

Growth and spread of deadly eye tumor suppressed in cells, animals

Phase III CLL14 study evaluating Venclexta plus Gazyva to treat CLL meets its primary endpoint

Novartis enters into clinical development agreement with Pfizer to improve treatment of NASH

Newly discovered compound shows potential for treating Parkinson's disease

New approach to understanding cancers will accelerate development of better treatments

Study identifies molecular switch that controls fate of milk-producing breast cells

Natural compound found in grapes may protect against cancer

Aggressive breast cancer hijacks normal protective physiological process to survive

Scientists perform successful trial of new antibiotic on cancer reoccurrence after surgery

Aggressive breast cancer cells hijack protective protein to aid growth

Why patients with ALL relapse after CAR-T cell therapy

Why patients with ALL relapse after CAR-T cell therapy

Researchers decipher antitumor mechanism of Amazonian plant in human cancer cells

Breakthrough observations made possible by label-free long-term 3D imaging of mitochondria

Research reveals how critical oocyte quality control process works

Multicolor Immunohistochemistry (IHC): Going Beyond a Single Color

Overcoming Challenges in High-Speed Centrifugation Experiments

From Our Bench to Yours: Antibody Advice from Proteintech

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