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Hearing loss linked to accelerated Alzheimer's progression via GDF1 pathway

Study unveils the GDF1 signaling pathway's role in mitigating the adverse effects of hearing loss on Alzheimer's disease, spotlighting potential avenues for therapeutic development.

20 Mar 2024

Healthy lifestyles linked to specific metabolic markers, large study finds

Researchers identify metabolomic markers linked to healthy lifestyles in a large study, showing a connection between lipid metabolism and reduced mortality risks.

18 Feb 2024

New study reveals flaws in AI tools used for SARS-CoV-2 antibody discovery

A discovery program for SARS-CoV-2-nABs potentially targeting its resistant strains.

19 Jan 2024

Hidden identity of blood cancer revealed

Leukemia is a common term used to refer to a form of blood cancer. However, there are different types of leukemia depending on the cell type involved.

9 Jan 2024

Discovery of a novel therapeutic target for pancreatic cancer

A novel amino acid transporter-based therapeutic target for pancreatic ductal adenocarcinoma (PDAC).

10 Oct 2023

Unlocking the power of lectins: BOA emerges as a potent weapon against all SARS-CoV-2 variants

Researchers discover that antiviral lectins like BOA can effectively inhibit SARS-CoV-2 and its variants by targeting spike glycans, opening doors for potential pan-coronavirus treatments. The study reveals that BOA's multivalent interactions make it a potent inhibitor against a range of viral variants, offering promise for future therapeutic strategies.

14 Sep 2023

Clovibactin - a game-changing novel antibiotic with no resistance

Researchers reported the discovery of a new antibiotic, clovibactin.

6 Sep 2023

SARS-CoV-2 variants show altered glycan processing

Researchers examine spike-protein trimers from SARS-CoV-2 variants to compare the N (asparagine)-glycan landscape.

15 May 2023

The dynamics and interactions between the skin metabolome, microbiome, and UV exposure

Researchers evaluated metabolic profile changes of the skin in relation to microbiota and UV exposure.

5 May 2023

Vitamin A-rich diet may reduce risk of developing asparaginase-associated pancreatitis in ALL patients

Consuming a diet rich in vitamin A or its analogs may help prevent children and young adults with acute lymphoblastic leukemia (ALL) reduce their risk of developing painful pancreas inflammation during chemotherapy treatment.

15 Mar 2023

Novel approach could pave the way for new treatments to prevent relapse in breast cancer patients

Cambridge scientists have managed to identify and kill those breast cancer cells that evade standard treatments in a study in mice.

20 Dec 2022

Study identifies novel inhibitors against SARS-CoV-2 main protease

In a recent study posted to the bioRxiv* server, researchers at the University of Arizona screened ~11 million severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (MPro)-inhibiting small compounds in the ZINC15 database using a structure-based in-silico screening method.

8 Nov 2022

Biochemical and structural evidence demonstrates Omicron mutations are better adapted to mouse ACE2 than to human ACE2

Researchers demonstrated the structural basis of how the receptor-binding domain nested Omicron mutations have adapted to mouse angiotensin-converting enzyme 2 rather than human ACE2.

22 Oct 2022

O-linked sialoglycans affect SARS-CoV-2 spike cleavage

In a recent study posted to the bioRxiv* preprint server, researchers from Spain, the United Kingdom, and the United States used chemical tools to uncover the molecular details of glycan-mediated modulation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) processing.

19 Sep 2022