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First large-scale study of proteins inside human cells called Jurkat T cells

The study, which appears in the August issue of Molecular & Cellular Proteomics, could lead to a better understanding of how proteins inside a specific type of cell work together and may pave the way for future detailed studies of how proteins work in other types of cells.

24 Aug 2007

All eukaryotic kinases share 1 common set of substrates

Kinase mediated phosphorylation is generally recognised as the major regulator of virtually all metabolic activities in eukaryotic cells including proliferation, gene expression, motility, vesicular transport and programmed cell death.

24 Aug 2007

Insight into autism's origin in the brain

In the first study of its kind, researchers have discovered that in autistic individuals, connections between brain cells may be deficient within single regions, and not just between regions, as was previously believed.

23 Aug 2007

Rapamycin study is first stage in development of new treatment

Rapamycin isn't your ordinary potential anti-cancer drug…It had a long and somewhat exotic history before undergoing preclinical (laboratory-based) studies at St. Jude as part of a national Pediatric Preclinical Testing Program (PPTP) investigation of its anticancer activity.

23 Aug 2007

Study helps predict anesthesia-linked risks for children with chest tumors

Children with mediastinal masses - tumors in their chest outside the lungs - are at special risk for developing breathing problems when they undergo anesthesia. These young patients are of special concern to clinicians who must anesthetize them as part of their medical treatment.

23 Aug 2007

Cancer stem cell scientists get $1.7 million to develop new leukemia drugs

"Modern cancer treatments fail to get to the root of the cancer - the stem cells - which is why many cancers recur despite aggressive treatment."

23 Aug 2007

Kidney removed through belly button

Surgeons specializing in laparoscopic procedures at UT Southwestern Medical Center have successfully removed a patient's kidney by performing a unique nephrectomy entirely through the belly button.

23 Aug 2007

Cell-based sensor for analysis of EGFR biomarker expression in oral cancer

Using a microfluidic device designed to capture and enrich cells from biological samples, a research team at The University of Texas at Austin has developed a test that can detect an important early marker for oral squamous cell carcinoma, which accounts for more than 90 percent of oral cancers. Oral cancer is the sixth most common cancer worldwide and is difficult to detect early enough to treat successfully.

22 Aug 2007

Antitumour drugs impede DNA uncoiling by topoisomerase I

The annoying bulges of an overwound telephone cord that shorten its reach and limit a caller's motion help explain why drugs called camptothecins are so effective in killing cancer cells, according to investigators led by Mary-Ann Bjornsti, Ph.D., at St. Jude Children’s Research Hospital, and Nynke Dekker, Ph.D., at Delft Technology University.

22 Aug 2007

Nanotubes offer new approach to cancer radiotherapy

Radioactive elements, or radionuclides, are well-established anticancer agents whose main limitation is that they kill healthy cells almost as easily as they do tumors. But because nanoparticles can be targeted to tumors, researchers have seized on the idea of using nanoparticles to deliver radionuclides to tumors, thus sparing healthy tissues from radiation-induced damage.

22 Aug 2007

Targeted quantum dot conjugates for siRNA delivery

Take a quantum dot, add a coating of poly(ethylene glycol) (PEG), and attach a homing peptide and a piece of small interfering RNA (siRNA), and the result is a targeted nanoparticle that can stop the production of a specific protein by a targeted cell.

22 Aug 2007

Vaccine suppresses aggregates of tau protein - implications for Alzheimer's

A new study by NYU Medical Center researchers shows for the first time that the immune system can combat the pathological form of tau protein, a key protein implicated in Alzheimer's disease.

22 Aug 2007

Cranberries, chemo and ovarian cancer

Compounds in cranberries may help improve the effectiveness of platinum drugs that are used in chemotherapy to fight ovarian cancer, researchers have found in a laboratory study that will be reported at the 234 th national meeting of the American Chemical Society.

22 Aug 2007

Clemson scientists improve longevity of fluorescent nanoparticles

Clemson University chemists have developed a method to dramatically improve the longevity of fluorescent nanoparticles that may someday help researchers track the motion of a single molecule as it travels through a living cell.

22 Aug 2007

New Cockayne syndrome discovery

Scientists of the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have shown that the genetic defect that causes Cockayne Syndrome affects a key function of the cell – the transcription of genes coding for ribosomal RNA.

21 Aug 2007

Natural protection provides possible new treatments for stroke

Two substances that occur naturally in the brain act to protect the brain during a stroke. This is the conclusion of a dissertation published at the Sahlgrenska Academy, and the discovery may lead to new treatments for stroke patients.

21 Aug 2007

Critical blood shortage in southeastern Michigan

The American Red Cross Southeastern Michigan Blood Services Region is issuing an urgent appeal for blood donors. Recent extraordinary patient needs and consistent low donor turnout this month have caused the local blood supply to drop to critically low levels.

21 Aug 2007

Red and blue fruits and veggies the best for fighting cancer

A new study by scientists in the U.S. has found that red and blue foods are the best when it comes to fighting cancer.

20 Aug 2007

We need to treat cancer like an infectious disease

Among the many medical miracles produced by science over the years, vaccines and antibiotics have undoubtedly saved the most lives.

17 Aug 2007

Drug topotecan shows promise against Wilms tumor

St. Jude researchers have shown that the drug topotecan holds promise as a treatment for the recurrent form of a kidney cancer called Wilms tumor, a solid tumor of the kidney that arises from immature kidney cells, and the fifth most common tumor among children.

17 Aug 2007