B Lymphocyte News and Research

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Scientists discover how T-cell leukemia viruses evade defense mechanisms

National Cancer Institute (NCI) scientists have discovered how human T-cell leukemia virus type 1 (HTLV-1), which infects about 20 million people worldwide, evades being held in check by one of the body's natural defense mechanisms.

6 Feb 2007

Novel approach to synthesizing nanowires

A novel approach to synthesizing nanowires (NWs) allows their direct integration with microelectronic systems for the first time, as well as their ability to act as highly sensitive biomolecule detectors that could revolutionize biological diagnostic applications, according to a report in Nature.

31 Jan 2007

Why organs fail following massive trauma

Massive trauma, say from a sabertooth tiger attack, meant immediate death for the primitive human.

17 Oct 2006

New method of gene therapy alters immune cells for treatment of advanced melanoma

A team of researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, has demonstrated sustained regression of advanced melanoma in a study of 17 patients by genetically engineering patients' own white blood cells to recognize and attack cancer cells.

4 Sep 2006

Interaction of proteins in the intestinal system may be allergic indicators

Researchers have identified one of the proteins that may be responsible for causing food allergies, which could lead to the development of more accurate non-invasive tests to identify true food allergies.

25 Jul 2006

SuperGen receives patent for composition and method for treating graft-versus-host disease

SuperGen has announced the issuance of U.S. Patent No. 7,037,900 B2 entitled, "Composition and Method for Treating Graft-versus-Host Disease."

5 Jun 2006

Gene key to infection-fighting immune cells identified

Every time the human body encounters a virus, bacteria or other infectious agent, immune cells called B-lymphocytes multiply in lymph nodes and then swing into action to fight off the intruders.

3 Apr 2006

Inefficient cytotoxic T lymphocyte mediated killing of HIV-1 infected cells in vivo

HIV attacks the immune system by infecting and killing helper T lymphocytes (also called CD4 T cells), the white blood cells responsible for mobilizing the mediators of an immune response.

15 Mar 2006

Children could be saved from neuroblastoma using antibody therapy

Combination of T cell, antibody to neuroblastoma cells and molecule that spurs T cell growth is designed to treat low initial tumor levels or small cancer cell populations that survive initial treatment, according to St. Jude.

22 Dec 2005

Master switch for blood cell development detected

Blood cells develop from blood stem cells in the bone marrow. Their development is regulated by roughly 20 gene regulators or transcription factors.

28 Nov 2005

Zinc supplements safe for chidren with HIV

Zinc-deficient children living in communities where they do not receive adequate amounts of zinc from their diet should be given supplements, even if they are HIV-infected, according to researchers from the Johns Hopkins Bloomberg School of Public Health and other institutions.

26 Nov 2005

Researchers shed light on a key molecular switch in T helper cells

Defects in immune system cells called T helper cells may lead to diseases characterized by a faulty inflammatory response such as autoimmunity and asthma. Understanding the molecular steps involved in how T helper cells mature may help researchers develop treatments for these diseases.

17 Oct 2005

Protein thought to promote lymphoma by merely preventing cancer cells from dying appears to actively promote cancer cell growth

A protein previously thought to merely hinder the activity of a key cellular protein linked to cancer cell death, now appears to mimic the cellular signaling of that protein; potentially leading to the development of lymphoma.

22 Aug 2005

Chromos Molecular Systems issued four key patents

Chromos Molecular Systems has announced that it has further expanded the patent portfolio surrounding both its ACE System and REM Technology with the issuance of four key additional patents.

15 Jul 2005

Researchers demonstrate direct transfer of terminally differentiated cell nuclei

With the advent of nuclear-transfer cloning, it is now possible to produce mice from the nuclei of differentiated cells, such as peripheral blood lymphocytes and olfactory sensory neurons.

20 Jun 2005

Inexpensive tests can be used to decide who needs HIV treatment in poor countries

Researchers from the Johns Hopkins Bloomberg School of Public Health, Centers for Disease Control and Prevention and the Chiang Mai University in Thailand, evaluated the ability of inexpensive biological markers, which are obtainable in resource-poor countries, to determine which HIV-infected patients are in the greatest need of antiretroviral therapy.

20 Jun 2005

Scientists show nuclear protein Ezh2 helps establish previously unknown signaling pathway in cells

Since 2001, scientists have wrestled with the discovery that there are fewer genes in humans than biological processes linked to those genes over the course of a human lifespan. One way to understand genetically coded events is by studying epigenetics, the regulation and heritability of genes at a cellular level due to molecular changes to the many proteins (called histones) that package DNA in a cell's nucleus.

23 May 2005

Routine, inexpensive blood test sharpens heart disease risk predictions

Routine measurements of white blood cell counts that provide a ratio of neutrophils to lymphocytes may offer a simple and low-cost way to refine predictions of heart attack or death, according to a new study in the May 17, 2005, issue of the Journal of the American College of Cardiology.

18 May 2005

Drugs that block the enzyme Odc prevent the onset of cancers

The drug DFMO prevents cancer in laboratory models of lymphoma but fails to kill existing cancerous cells that have lost the ability to self-destruct, according to investigators at St. Jude Children's Research Hospital.

16 May 2005

HIV treatment not affected by hormonal birth control

Estrogen and progesterone hormones in birth control do not influence the effectiveness of highly active antiretroviral therapy (HAART), which is used to treat HIV infection, according to researchers from the Johns Hopkins Bloomberg School of Public Health and other institutions. The study is published in the May 1, 2005, issue of the American Journal of Epidemiology.

2 May 2005