Celiac Disease News and Research

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Celiac disease is an inherited autoimmune disorder where gluten has been identified as the environmental trigger of the disease. Gluten is an ingested protein found in wheat, barley and rye. Gluten is broken down into gliadin which can pass through the intestinal epithelial barrier during times of increased intestinal permeability. The ingestion of gluten causes an immune response which triggers an inflammatory reaction in the small intestine. This then causes damage to the villi in the small intestine and can lead to total villous atrophy in celiac disease. This results in varying symptoms such as fatigue, skin rash, anemia, fertility issues, joint pain, weight loss, pale sores inside the mouth, tooth discoloration or loss of enamel, depression, chronic diarrhea or constipation, gas and abdominal pain. The immunology and nutritional abnormalities in celiac disease can potentially result in long- term complications such as osteoporosis, refractory sprue, small intestinal cancer, and lymphoma.

Celiac disease is a growing public health concern, affecting approximately 3 million people in the United States and over 6.5 million people worldwide. The only current management of celiac disease is complete elimination of gluten from the diet, which can be very difficult to implement in practice. Additionally, the response to the gluten-free diet is poor in up to 30% of patients, and dietary nonadherence is the chief cause of persistent or recurrent symptoms.
Raising Awareness of Coeliac Disease with Coeliac UK

Raising Awareness of Coeliac Disease with Coeliac UK

Discovery may help identify signs of type 1 diabetes earlier

Discovery may help identify signs of type 1 diabetes earlier

Study calls for screening of all first-degree relatives of celiac disease patients

Study calls for screening of all first-degree relatives of celiac disease patients

Type 1 diabetes linked to gut microbiome and genetic factors

Type 1 diabetes linked to gut microbiome and genetic factors

Genetic risk for autoimmunity may be linked to differences in gut microbiome

Genetic risk for autoimmunity may be linked to differences in gut microbiome

High gluten intake during childhood increases risk of celiac disease

High gluten intake during childhood increases risk of celiac disease

New test reveals truth behind gluten-free labels

New test reveals truth behind gluten-free labels

Study explores long-term impact of food restrictions on normal eating patterns in patients

Study explores long-term impact of food restrictions on normal eating patterns in patients

Novel non-invasive test for diagnosing gut diseases

Novel non-invasive test for diagnosing gut diseases

Study: Micronutrient deficiencies are common in adults at the time of celiac disease diagnosis

Study: Micronutrient deficiencies are common in adults at the time of celiac disease diagnosis

Coeliac UK and Innovate UK announce £180k research funding

Coeliac UK and Innovate UK announce £180k research funding

Scientists highlight advances and uses of organoids in gastroenterology and hepatology

Scientists highlight advances and uses of organoids in gastroenterology and hepatology

Researchers develop new method to reduce toxicity of gluten for people with celiac disease

Researchers develop new method to reduce toxicity of gluten for people with celiac disease

Many of the symptoms for IBS could actually be undiagnosed celiac disease

Many of the symptoms for IBS could actually be undiagnosed celiac disease

Researchers create ‘mini-guts’ to explore how gut epithelium respond to gluten in celiac patients

Researchers create ‘mini-guts’ to explore how gut epithelium respond to gluten in celiac patients

Gut bacteria and pregnancy

Gut bacteria and pregnancy

Study: About one-third of gluten-free foods tested positive for presence of gluten

Study: About one-third of gluten-free foods tested positive for presence of gluten

MUSC study provides evidence for link between 'leaky gut' and autoantibody production in HIV-positive patients

MUSC study provides evidence for link between 'leaky gut' and autoantibody production in HIV-positive patients

Study shows how some autoimmune diseases are more closely related than others

Study shows how some autoimmune diseases are more closely related than others

Novel breath test could pave new way to non-invasively measure gut health

Novel breath test could pave new way to non-invasively measure gut health