Celiac Disease News and Research

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Celiac disease is an inherited autoimmune disorder where gluten has been identified as the environmental trigger of the disease. Gluten is an ingested protein found in wheat, barley and rye. Gluten is broken down into gliadin which can pass through the intestinal epithelial barrier during times of increased intestinal permeability. The ingestion of gluten causes an immune response which triggers an inflammatory reaction in the small intestine. This then causes damage to the villi in the small intestine and can lead to total villous atrophy in celiac disease. This results in varying symptoms such as fatigue, skin rash, anemia, fertility issues, joint pain, weight loss, pale sores inside the mouth, tooth discoloration or loss of enamel, depression, chronic diarrhea or constipation, gas and abdominal pain. The immunology and nutritional abnormalities in celiac disease can potentially result in long- term complications such as osteoporosis, refractory sprue, small intestinal cancer, and lymphoma.

Celiac disease is a growing public health concern, affecting approximately 3 million people in the United States and over 6.5 million people worldwide. The only current management of celiac disease is complete elimination of gluten from the diet, which can be very difficult to implement in practice. Additionally, the response to the gluten-free diet is poor in up to 30% of patients, and dietary nonadherence is the chief cause of persistent or recurrent symptoms.
Study offers novel insights into how genetic variants play key role in human immune system

Study offers novel insights into how genetic variants play key role in human immune system

Biomedical scientist receives $1.83 million NIH grant for inflammatory bowel disease research

Biomedical scientist receives $1.83 million NIH grant for inflammatory bowel disease research

Mango intake exerts beneficial effects in progression and severity of IBD

Mango intake exerts beneficial effects in progression and severity of IBD

Infections during infancy linked to greater risk for celiac disease

Infections during infancy linked to greater risk for celiac disease

Phase 1 clinical studies reveal safety, tolerability of therapeutic vaccine in celiac disease patients

Phase 1 clinical studies reveal safety, tolerability of therapeutic vaccine in celiac disease patients

Enzyme supplement can potentially reduce uncomfortable symptoms in gluten-sensitive patients

Enzyme supplement can potentially reduce uncomfortable symptoms in gluten-sensitive patients

New study uses 10x Genomics’ Single Cell 3’ Solution to unravel stem cell self-renewal mechanism

New study uses 10x Genomics’ Single Cell 3’ Solution to unravel stem cell self-renewal mechanism

Study reveals gluten diet is not connected with heart disease among non-celiac people

Study reveals gluten diet is not connected with heart disease among non-celiac people

Study finds no link between gluten intake and heart disease risk in people without celiac disease

Study finds no link between gluten intake and heart disease risk in people without celiac disease

Study highlights risk factors for widespread vitamin D deficiency

Study highlights risk factors for widespread vitamin D deficiency

MGH researchers provide direct link between ‘leaky gut’ and chronic inflammatory disease

MGH researchers provide direct link between ‘leaky gut’ and chronic inflammatory disease

Opportunities and risks of direct-to-consumer genetic health risk tests

Opportunities and risks of direct-to-consumer genetic health risk tests

Viral trigger may underlie development of celiac disease

Viral trigger may underlie development of celiac disease

UC Riverside professor receives grant to explore therapeutic target for treating IBD patients

UC Riverside professor receives grant to explore therapeutic target for treating IBD patients

Infection with reovirus could be key initiating event for developing celiac disease, study suggests

Infection with reovirus could be key initiating event for developing celiac disease, study suggests

FDA authorizes marketing of first direct-to-consumer GHR tests for certain diseases

FDA authorizes marketing of first direct-to-consumer GHR tests for certain diseases

Physicians recommend whole food, plant-based eating patterns for optimal heart health

Physicians recommend whole food, plant-based eating patterns for optimal heart health

Discovery of 'molecular switch' could lead to effective new treatments for auto-immune diseases

Discovery of 'molecular switch' could lead to effective new treatments for auto-immune diseases

Gluten-free diets linked to increased risk for arsenic and mercury exposure

Gluten-free diets linked to increased risk for arsenic and mercury exposure

Type 1 diabetes patients show distinct signs of gut inflammation, study reveals

Type 1 diabetes patients show distinct signs of gut inflammation, study reveals