Celiac Disease News and Research

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Celiac disease is an inherited autoimmune disorder where gluten has been identified as the environmental trigger of the disease. Gluten is an ingested protein found in wheat, barley and rye. Gluten is broken down into gliadin which can pass through the intestinal epithelial barrier during times of increased intestinal permeability. The ingestion of gluten causes an immune response which triggers an inflammatory reaction in the small intestine. This then causes damage to the villi in the small intestine and can lead to total villous atrophy in celiac disease. This results in varying symptoms such as fatigue, skin rash, anemia, fertility issues, joint pain, weight loss, pale sores inside the mouth, tooth discoloration or loss of enamel, depression, chronic diarrhea or constipation, gas and abdominal pain. The immunology and nutritional abnormalities in celiac disease can potentially result in long- term complications such as osteoporosis, refractory sprue, small intestinal cancer, and lymphoma.

Celiac disease is a growing public health concern, affecting approximately 3 million people in the United States and over 6.5 million people worldwide. The only current management of celiac disease is complete elimination of gluten from the diet, which can be very difficult to implement in practice. Additionally, the response to the gluten-free diet is poor in up to 30% of patients, and dietary nonadherence is the chief cause of persistent or recurrent symptoms.
Study explores long-term impact of food restrictions on normal eating patterns in patients

Study explores long-term impact of food restrictions on normal eating patterns in patients

Novel non-invasive test for diagnosing gut diseases

Novel non-invasive test for diagnosing gut diseases

Study: Micronutrient deficiencies are common in adults at the time of celiac disease diagnosis

Study: Micronutrient deficiencies are common in adults at the time of celiac disease diagnosis

Coeliac UK and Innovate UK announce £180k research funding

Coeliac UK and Innovate UK announce £180k research funding

Scientists highlight advances and uses of organoids in gastroenterology and hepatology

Scientists highlight advances and uses of organoids in gastroenterology and hepatology

Researchers develop new method to reduce toxicity of gluten for people with celiac disease

Researchers develop new method to reduce toxicity of gluten for people with celiac disease

Many of the symptoms for IBS could actually be undiagnosed celiac disease

Many of the symptoms for IBS could actually be undiagnosed celiac disease

Researchers create ‘mini-guts’ to explore how gut epithelium respond to gluten in celiac patients

Researchers create ‘mini-guts’ to explore how gut epithelium respond to gluten in celiac patients

Gut bacteria and pregnancy

Gut bacteria and pregnancy

Study: About one-third of gluten-free foods tested positive for presence of gluten

Study: About one-third of gluten-free foods tested positive for presence of gluten

MUSC study provides evidence for link between 'leaky gut' and autoantibody production in HIV-positive patients

MUSC study provides evidence for link between 'leaky gut' and autoantibody production in HIV-positive patients

Study shows how some autoimmune diseases are more closely related than others

Study shows how some autoimmune diseases are more closely related than others

Novel breath test could pave new way to non-invasively measure gut health

Novel breath test could pave new way to non-invasively measure gut health

Most pills contain common allergens, warn experts

Most pills contain common allergens, warn experts

Gluten, lactose, food dyes in pills could be causing side effects finds study

Gluten, lactose, food dyes in pills could be causing side effects finds study

Fecal transplantation improves the gut of IBS patients

Fecal transplantation improves the gut of IBS patients

Celiac disease may be caused by gastrointestinal infection in childhood

Celiac disease may be caused by gastrointestinal infection in childhood

Gluten-free wheat can be produced for people with celiac disease by using gene editing

Gluten-free wheat can be produced for people with celiac disease by using gene editing

Common food additive could cause celiac disease, review says

Common food additive could cause celiac disease, review says

Study follows children into adolescence to more accurately assess type 1 diabetes risk

Study follows children into adolescence to more accurately assess type 1 diabetes risk