Crohn's Disease News and Research

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Crohn’s disease is a chronic inflammatory disease of the bowel affecting at least 115,000 people in the UK. The condition usually develops in teenagers and young adults, but can be diagnosed at any age and is equally common in men and women.

The condition can affect any part of the digestive tract between the mouth and the anus, although inflammation in the last section of the small bowel (ileum) or the first part of the large bowel (colon) is most common.

Crohn's disease is a ‘relapsing and remitting’ condition characterized by symptom-free periods followed by episodes of “flare-ups,” during which symptoms such as diarrhoea, abdominal pain, fever and fatigue may become particularly bothersome.

Long term, severe inflammation can damage sections of the digestive system, resulting in additional complications, such as a tear in the wall of the anus (fissure), narrowing of the intestine (stricture) or the formation of an abnormal connection between the bowel and another body part such as the bladder, vagina or skin (fistula). Such problems usually require surgical treatment to correct. Crohn's disease also increases the risk of developing bowel cancer.

The exact cause of Crohn's disease is not clear but experts believe a combination of factors may be at work including genetics, immune responses to certain bacteria or viruses and lifestyle factors such as diet or smoking status.
Higher body temperatures speed the bodies' responses to infections and tumors, finds research

Higher body temperatures speed the bodies' responses to infections and tumors, finds research

Researchers discover new disease mechanism in chronic tobacco smokers

Researchers discover new disease mechanism in chronic tobacco smokers

Study: Psoriasis patients taking Humira show no change in aortic inflammation

Study: Psoriasis patients taking Humira show no change in aortic inflammation

Scientists develop integrated system for early diagnosis of diseases using wearable monitors

Scientists develop integrated system for early diagnosis of diseases using wearable monitors

Researchers uncover role of ROS in clearing dead cells

Researchers uncover role of ROS in clearing dead cells

Study points to new treatments for incurable bowel conditions

Study points to new treatments for incurable bowel conditions

New study compares gut bacteria of vapers, non- smokers and tobacco smokers

New study compares gut bacteria of vapers, non- smokers and tobacco smokers

Western diets promote bacterial growth in the small intestine, increase fat digestion and absorption

Western diets promote bacterial growth in the small intestine, increase fat digestion and absorption

Researchers gain ground-breaking insights into how inflammatory diseases work

Researchers gain ground-breaking insights into how inflammatory diseases work

Preantral zinc deficiency may affect fertility months

Preantral zinc deficiency may affect fertility months

'Gut-on-a-chip' model recreates intestinal matrix critical for nutrient absorption

'Gut-on-a-chip' model recreates intestinal matrix critical for nutrient absorption

Discovery of 100 new genes may aid research into pigmentation diseases

Discovery of 100 new genes may aid research into pigmentation diseases

Specific small-bowel microbes regulate digestion and absorption of fats, study shows

Specific small-bowel microbes regulate digestion and absorption of fats, study shows

Analysis does not reveal consistent link between NSAIDs use and exacerbation of inflammatory bowel disease

Analysis does not reveal consistent link between NSAIDs use and exacerbation of inflammatory bowel disease

Anti-TNF medications appear to be safe for use during pregnancy, study shows

Anti-TNF medications appear to be safe for use during pregnancy, study shows

New review explores potentially safer therapies for treating chronic abdominal pain

New review explores potentially safer therapies for treating chronic abdominal pain

Macrophages stimulated to produce potent anti-inflammatory molecule

Macrophages stimulated to produce potent anti-inflammatory molecule

Artificial sweetener sucralose worsens gut inflammation in mice with Crohn's disease

Artificial sweetener sucralose worsens gut inflammation in mice with Crohn's disease

University Hospitals study suggests strong connection between IBD and heart attacks

University Hospitals study suggests strong connection between IBD and heart attacks

Inflammatory bowel disease linked to elevated risk of heart attack

Inflammatory bowel disease linked to elevated risk of heart attack