Crohn's Disease News and Research

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Crohn’s disease is a chronic inflammatory disease of the bowel affecting at least 115,000 people in the UK. The condition usually develops in teenagers and young adults, but can be diagnosed at any age and is equally common in men and women.

The condition can affect any part of the digestive tract between the mouth and the anus, although inflammation in the last section of the small bowel (ileum) or the first part of the large bowel (colon) is most common.

Crohn's disease is a ‘relapsing and remitting’ condition characterized by symptom-free periods followed by episodes of “flare-ups,” during which symptoms such as diarrhoea, abdominal pain, fever and fatigue may become particularly bothersome.

Long term, severe inflammation can damage sections of the digestive system, resulting in additional complications, such as a tear in the wall of the anus (fissure), narrowing of the intestine (stricture) or the formation of an abnormal connection between the bowel and another body part such as the bladder, vagina or skin (fistula). Such problems usually require surgical treatment to correct. Crohn's disease also increases the risk of developing bowel cancer.

The exact cause of Crohn's disease is not clear but experts believe a combination of factors may be at work including genetics, immune responses to certain bacteria or viruses and lifestyle factors such as diet or smoking status.
New approach identifies genes that help microbes to survive in the human gut

New approach identifies genes that help microbes to survive in the human gut

Clinical trial to use stem cell transplants for treating Crohn's disease

Clinical trial to use stem cell transplants for treating Crohn's disease

Penn Medicine receives federal government approval to develop imaging guidelines

Penn Medicine receives federal government approval to develop imaging guidelines

Researchers discover new protein that controls level of inflammation-inducing molecule

Researchers discover new protein that controls level of inflammation-inducing molecule

Long-lasting HIV control without antiretroviral therapy is a feasible goal, says expert

Long-lasting HIV control without antiretroviral therapy is a feasible goal, says expert

Scientists find key link between viruses and inflammatory bowel diseases

Scientists find key link between viruses and inflammatory bowel diseases

New machine learning framework predicts effects of genetic mutations in ‘dark matter’ regions

New machine learning framework predicts effects of genetic mutations in ‘dark matter’ regions

Targeting amino acid transporter may improve survival rates for non-small cell lung cancer patients

Targeting amino acid transporter may improve survival rates for non-small cell lung cancer patients

Study offers new hope for people with disabling Dupuytren's disease

Study offers new hope for people with disabling Dupuytren's disease

Researchers develop ingestible sensor to non-invasively monitor indicators of disease

Researchers develop ingestible sensor to non-invasively monitor indicators of disease

Researchers discover immune cells that create and sustain chronic inflammatory bowel disease

Researchers discover immune cells that create and sustain chronic inflammatory bowel disease

Dynamic model helps make predictions about gut microbiome

Dynamic model helps make predictions about gut microbiome

Biosimilar competition may offer hope for cheaper, better psoriasis treatments in the future

Biosimilar competition may offer hope for cheaper, better psoriasis treatments in the future

SetPoint announces positive long-term results of bioelectronic medicine to treat rheumatoid arthritis

SetPoint announces positive long-term results of bioelectronic medicine to treat rheumatoid arthritis

Cedars-Sinai study identifies gut gas associated with diarrhea

Cedars-Sinai study identifies gut gas associated with diarrhea

Novel PET imaging shows promise for noninvasively detecting inflammation in people with IBD

Novel PET imaging shows promise for noninvasively detecting inflammation in people with IBD

Researchers trigger natural defense mechanism to alleviate intestinal inflammation

Researchers trigger natural defense mechanism to alleviate intestinal inflammation

OSU biologist describes 'restoration ecology' approach toward patient health

OSU biologist describes 'restoration ecology' approach toward patient health

AARDA collaborates with Allegheny Health Network and new AHN Autoimmunity Institute

AARDA collaborates with Allegheny Health Network and new AHN Autoimmunity Institute

Researchers reveal potent new mechanism of action for treatment of IBD

Researchers reveal potent new mechanism of action for treatment of IBD