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CAR T-cell therapy triples expected length of remission for relapsed multiple myeloma patients

A new type of CAR T-cell therapy more than triples the expected length of remission for multiple myeloma patients who have relapsed several times, according to an international clinical trial with UT Southwestern as the lead enrolling site.

8 Mar 2021

Rheumatoid arthritis drug improves outcomes in severely ill COVID-19 patients, finds new trial

Tocilizumab, an anti-inflammatory drug used to treat rheumatoid arthritis, improves outcomes in severely ill COVID-19 patients, finds the results of a new trial conducted in hospitals across India -- one of the world's most ethnically diverse countries.

8 Mar 2021

Study rethinks the role of ACE2 in SARS-CoV-2 viral entry

Researchers in the US recently infected a series of human lung and head/neck cancer cell lines with SARS-CoV-2 that expressed varying levels of ACE2 and the TMPRSS2 protease to reassess their role in viral entrance.

8 Mar 2021

Impairments in immune response contribute to severe COVID-19

New research by a team of scientists at University Hospital RWTH Aachen in Germany and Erasmus Medical Centre in The Netherlands characterized changes in CD8+ T cells in response to SARS-CoV-2.

8 Mar 2021

Combined liver-cytokine humanization enhances human red blood cell production and survival

In a new study by the Yale Department of Immunobiology and Yale Cancer Center, researchers report combined liver and growth factor humanization enhances human red blood cell production and survival in circulation the immunodeficient murine host.

5 Mar 2021

Combining terpenes and cannabidiol may be highly active against human coronaviruses

A group of researchers from a well-known technology company in Israel showed a significant antiviral effect of a combination of terpenes and cannabidiol against a human coronavirus strain 229E. This exciting and first-of-its-kind report is currently available on the bioRxiv preprint server.

4 Mar 2021

Novel host-viral-microbiome interactions during COVID-19 may determine outcome

A new preprint on the medRxiv* server discusses how the underlying disease mechanisms are regulated such that the local or mucosal immune response is distinct from the systemic response.

4 Mar 2021

Coronavirus deranges the immune system in complex and deadly ways

There's a reason soldiers go through basic training before heading into combat: Without careful instruction, green recruits armed with powerful weapons could be as dangerous to one another as to the enemy.

4 Mar 2021

Researchers examine long-term immune responses following COVID-19 across clinically diverse cohort

A new study by researchers at the University of California, San Francisco, discusses the different aspects of long-term immune responses in a wide sample of patients, as well as how they vary in clinical severity and sequelae.

3 Mar 2021

How SARS-CoV-2 proteins affect vascular functionality

The study, published on the pre-print server medRxiv, can pinpoint and isolate how each of the SARS-CoV-2 proteins independently affects the endothelial response and directly gauge endothelial functionality.

3 Mar 2021

Early antibody response predicts COVID-19 outcome

To address this gap, researchers from the U.S. evaluated the timing of antibody production against SARS-CoV-2 in hospitalized patients. They used a highly sensitive multiplexed bead-based immunoassay that allows for early detection of anti-SARS-CoV-2 antibodies. The study is published on the preprint server medRxiv.

2 Mar 2021

Children with MIS-C have highly activated immune systems, study finds

Taking the first deep dive into how the immune system is behaving in patients with multisystem inflammatory syndrome in children (MIS-C), researchers at Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania have found that children with this condition have highly activated immune systems that, in many ways, are more similar to those of adults with severe COVID-19.

2 Mar 2021

SARS-CoV-2 UK variant shows low virulence and high shedding in hamster model

A new study compares the pathogenicity and infectiousness of one such variant, the VOC 202012/01 (B.1.1.7 lineage) from the United Kingdom, with the globally dominant D614G mutation-carrying strains.

2 Mar 2021

Study shows how SARS-CoV-2 affects cytokines compared to other respiratory viruses

Respiratory viruses such as SARS-CoV-2 (causing COVID-19) can often catalyze an overactive immune response that leads to a life-threatening cycle, known as a cytokine storm.

2 Mar 2021

Study shows asthma mediator IL-13 prevents SARS-CoV-2 infection

In a paper published on the bioRxiv preprint server, researchers reported the results on whether IL-13 expression in asthma patients reduces their susceptibility to SARS-CoV-2 infection.

1 Mar 2021

Scientists establish infection models for SARS-CoV-2 UK & South African variants

New research suggests Syrian golden hamsters could be a potentially useful preclinical model for testing vaccine immunity against the acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.17 and B.1.351 variant.

1 Mar 2021

Study: Repurposed arthritis drug did not improve outcomes of patients with severe COVID-19 pneumonia

In a study published online February 25, 2021 in The New England Journal of Medicine, a repurposed drug used to treat arthritis did not significantly improve the outcomes of patients with severe COVID-19 pneumonia.

1 Mar 2021

Cellular maps capture COVID-19 pathogenesis in detail

Researchers in the United States and Finland have used tissues from people who died from coronavirus disease 2019 (COVID-19) to generate detailed cellular maps of the pathogenetic processes that occur within affected organs during severe disease.

1 Mar 2021

Is transposable element expression affected by SARS-CoV-2 infection?

A study by researchers in Israel aims to establish whether TE expression is altered in SARS-CoV-2 infected cells, and explores the implications for host immune response.

1 Mar 2021

NLRP3 inflammasome inhibitors may help treat early COVID-19, says study

A new study by researchers in the U.S. further supports the hypothesis that the unregulated release of inflammatory cytokines is responsible for the local and systemic inflammation that is associated with multi-organ damage and death in severe COVID-19.

26 Feb 2021

Cytokine News and Research

CAR T-cell therapy triples expected length of remission for relapsed multiple myeloma patients

Rheumatoid arthritis drug improves outcomes in severely ill COVID-19 patients, finds new trial

Study rethinks the role of ACE2 in SARS-CoV-2 viral entry

Impairments in immune response contribute to severe COVID-19

Combined liver-cytokine humanization enhances human red blood cell production and survival

Combining terpenes and cannabidiol may be highly active against human coronaviruses

Novel host-viral-microbiome interactions during COVID-19 may determine outcome

Coronavirus deranges the immune system in complex and deadly ways

Researchers examine long-term immune responses following COVID-19 across clinically diverse cohort

How SARS-CoV-2 proteins affect vascular functionality

Early antibody response predicts COVID-19 outcome

Children with MIS-C have highly activated immune systems, study finds

SARS-CoV-2 UK variant shows low virulence and high shedding in hamster model

Study shows how SARS-CoV-2 affects cytokines compared to other respiratory viruses

Study shows asthma mediator IL-13 prevents SARS-CoV-2 infection

Scientists establish infection models for SARS-CoV-2 UK & South African variants

Study: Repurposed arthritis drug did not improve outcomes of patients with severe COVID-19 pneumonia

Cellular maps capture COVID-19 pathogenesis in detail

Is transposable element expression affected by SARS-CoV-2 infection?

NLRP3 inflammasome inhibitors may help treat early COVID-19, says study

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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