DNA Damage News and Research

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Finnish mitochondrial disease of newborns shows cancer-like changes in proliferating cells

A study found that a mitochondrial disease of newborns shows cancer-like changes in proliferating cells, causing tissues to age prematurely.

3 May 2023

Melanoma research unveils landscape of DNA and RNA alterations across multiple organs of metastasis

In a new translational study from UCLA Jonsson Comprehensive Cancer Center, researchers analyzed genetic changes in the organs of recently deceased patients to understand how metastatic cutaneous melanoma spreads in those who had initially benefited from precision therapies.

27 Apr 2023

Study sheds light on the mechanisms behind circadian rhythms

New research from a multidisciplinary team helps to illuminate the mechanisms behind circadian rhythms, offering new hope for dealing with jet lag, insomnia and other sleep disorders.

26 Apr 2023

Study reveals a previously unknown mechanism for DNA folding

A hitherto unknown mechanism for DNA folding is described in a study in Nature published by researchers from Karolinska Institutet and the Max Planck Institute for Biophysics.

19 Apr 2023

Bonn researchers elucidate a mechanism underlying cisplatin resistance in testicular cancer

Cisplatin is used successfully in the chemotherapy of testicular cancer. However, patients who develop resistance to the cytostatic drug urgently need alternative therapy options.

11 Apr 2023

Antioxidant supplementation shows potential to improve male fertility

A new study discusses the benefits of antioxidant supplementation on male fertility.

4 Apr 2023

CRISPR screens reveal genetic determinants of PARP inhibition in prostate cancer

Prostate cancer tumors harboring BRCA1/2 mutations are exceptionally sensitive to PARP inhibitors, while genomic alterations in other DNA damage response (DDR) genes are less responsive.

4 Apr 2023

Researchers report surprising first steps that promote resistance to commonly prescribed antibiotics

Antibiotic resistance is a global health threat. In 2019 alone, an estimated 1.3 million deaths were attributed to antibiotic resistant bacterial infections worldwide.

31 Mar 2023

Beethoven's cause of death revealed through DNA analysis of his hair

In a recent article published in the journal Current Biology, an international team of researchers sequenced the whole genome to high coverage from eight authenticated hair strands from Ludwig van Beethoven, one of the most influential European classical music composers born in 1770. He died on March 27, 1827.

27 Mar 2023

Epigenome reprogramming after SARS-CoV-2 infection

Researchers performed a 3D evaluation of SARS-CoV-2 infected human cells.

27 Mar 2023

New discovery could help target the causes of aging and cancer development

A protein complex prevents the repair of genome damage in human cells, in mice and in the nematode Caenorhabditis elegans, a team of researchers at the University of Cologne has discovered.

23 Mar 2023

Study discovers a protein controlling resistance to chemotherapy

Despite the recent development of new targeted therapies, chemotherapies remain the most frequently used treatment to treat patients suffering from advanced cancers.

22 Mar 2023

Scientists discover mechanism used by cancer cells to repair DNA damage induced by radiotherapy

A team of scientists led by Dr. Kei-ichi TAKATA from the Center for Genomic Integrity within the Institute for Basic Science (IBS), has discovered a new type of DNA repair mechanism that cancer cells use to recover from next-generation cancer radiation therapy.

16 Mar 2023

DNA Damage News and Research

Finnish mitochondrial disease of newborns shows cancer-like changes in proliferating cells

Melanoma research unveils landscape of DNA and RNA alterations across multiple organs of metastasis

Study sheds light on the mechanisms behind circadian rhythms

Study reveals a previously unknown mechanism for DNA folding

Bonn researchers elucidate a mechanism underlying cisplatin resistance in testicular cancer

Antioxidant supplementation shows potential to improve male fertility

CRISPR screens reveal genetic determinants of PARP inhibition in prostate cancer

Researchers report surprising first steps that promote resistance to commonly prescribed antibiotics

Beethoven's cause of death revealed through DNA analysis of his hair

Epigenome reprogramming after SARS-CoV-2 infection

New discovery could help target the causes of aging and cancer development

Study discovers a protein controlling resistance to chemotherapy

Scientists discover mechanism used by cancer cells to repair DNA damage induced by radiotherapy

An emerging target for chronic kidney disease treatment - DNA-PKcs

How does dietary intervention affect aging?

Study shows SARS-CoV-2 causes DNA damage and elicits an altered DNA damage response

Research reveals the mechanism that triggers breast cancer 'time bomb'

Regular consumption of colorful fruits and vegetables could help prevent prostate cancer

Study unveils a key factor involved in the DNA damage response and repair

Common scientific method to analyze DNA in early human embryos fails to accurately reflect gene edits

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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