DNA Replication News and Research

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DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "semiconservative" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication.

Scientists uncover important functions of a special protein during cell division

In a new study, researchers from the University of Copenhagen have discovered two important functions of a protein called RTEL1 during cell division.

12 May 2020

Antibiotic exposure and its priming effect on disease-causing bacteria

Antibiotics save lives -- but using them also helps antibiotic-resistant strains evolve and spread. Each year, antibiotic-resistant bacteria infect some 2.8 million people in the United States, killing more than 35,000, according to the Centers for Disease Control and Prevention.

27 Apr 2020

Researchers find direct link between MCL1 protein and cell-cycle checkpoint protein

Human cells respond to stresses like DNA damage, metabolic imbalance and starvation by first trying to repair the problem.

5 Apr 2020

Uncovering the Achilles' heel of cancer cells to find effective cures

The key to effective cures for cancers is to find weak points of cancer cells that are not found in non-cancer cells.

17 Mar 2020

Researchers elucidate new mechanism for controlling DNA methylation in cells

Why normal cells turn into cancer cells One of the factors is deeply related to the failure of the cell differentiation mechanism called DNA methylation.

17 Mar 2020

NYU Abu Dhabi researchers develop nanocarrier for more effective cancer drug delivery

A team of researchers at NYU Abu Dhabi has developed a biocompatible, biodegradable, and economical nanocarrier for safer and more effective delivery of anticancer drugs.

3 Mar 2020

New discovery may be useful for developing novel cancer treatments

Researchers from the University of Copenhagen have discovered that our cells replicate their DNA much more loosely than previously thought.

28 Feb 2020

Increased brain growth, mutations and autism linked in new study

Salk Institute researchers have now found a pattern of DNA damage that is unique to brain cells derived from individuals with a single form of autism spectrum disorder (ASD) called macrocephalic ASD. The study, published in the journal Cell Stem Cell in January 2020, may offer an explanation about the developmental misstep that caused this disease.

30 Jan 2020

Novel palladium compound acts against ovarian tumor cells

A group led by a researcher affiliated with the University of São Paulo's São Carlos Chemistry Institute (IQSC-USP) in Brazil has developed a novel palladium compound that acts against ovarian tumor cells without affecting healthy tissues. Palladium is a silvery white metal belonging to the same group as platinum.

28 Jan 2020

Determining Microsatellite Instability Status Using Multiplex PCR-Based Methods

Determining microsatellite instability status using multiplex PCR-based methods used to screen for Lynch Syndrome, a dominant hereditary cancer propensity.

From Promega Corporation 24 Jan 2020

Inexpensive drug may be used to counteract treatment resistance in patients with leukemia

A common and inexpensive drug may be used to counteract treatment resistance in patients with acute myeloid leukemia, one of the most common forms of blood cancer.

17 Jan 2020

New molecular mechanism can reverse genetic defect responsible for Friedreich's ataxia

Scientists at Tufts University have identified a molecular mechanism that could reverse the genetic defect responsible for Friedreich's ataxia, a neurodegenerative disease that leaves its victims with difficulty walking, a loss of sensation in the arms and legs and impaired speech caused by degeneration of nerve tissue in the spinal cord.

6 Jan 2020

Research shows how the hepatitis D virus copies itself

A team of researchers has discovered how one crucial step occurs in the lifecycle of the hepatitis D virus (HDV), which causes the widespread and hard to treat liver inflammation called hepatitis D. The study, which was published recently in the Journal of Virology, could help develop antiviral therapy to control this disease.

22 Dec 2019

Crick study reveals vital protective role of telomere t-loops

Loops at the ends of telomeres play a vital protective role preventing irretrievable damage to chromosomes, according to new research from the Crick.

From The Francis Crick Institute 12 Nov 2019

Study presents a new view on how mitochondrial dysfunction may contribute to aging

Disturbances in the function of mitochondrial DNA can accelerate the aging process in ways that are different than previously thought, according to a new Finnish study published in Nature Metabolism.

8 Oct 2019

The atomic-level structure of DNA polymerase delta – the enzyme behind DNA replication

A new study has revealed how the fundamental enzyme called DNA polymerase delta operates during DNA replication, making a copy of the genetic code that can be transmitted through the generations.

4 Oct 2019

UCR biochemist receives grant to develop novel lead compound to treat breast cancer

A biochemist at the University of California, Riverside, has received a grant from the Congressionally Directed Medical Research Programs, or CDMRP, of the U.S. Department of Defense to develop a novel lead compound to treat breast cancer, the second most commonly diagnosed cancer among American women.

3 Oct 2019

New mechanism that controls DNA repair identified

Deoxyribonucleic acid (DNA), is the macromolecule that holds all hereditary and genetic information. Continuously under assault, alterations and damage to DNA can lead to many different health issues, including cancer.

2 Oct 2019

Discovery of neoantigens could widen the possibilities for universal cancer vaccine

For more than a decade, scientist Stephen Albert Johnston and his team at Arizona State University's Biodesign Institute have pooled their energies into an often scoffed-at, high-risk, high-reward goal in medicine: to develop a universal vaccine to prevent cancer.