Dasatinib News and Research

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Dasatinib is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoting activities of these kinases. Apparently because of its less stringent binding affinity for the BCR-ABL kinase, dasatinib has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations. SRC-family protein-tyrosine kinases interact with variety of cell-surface receptors and participate in intracellular signal transduction pathways; tumorigenic forms can occur through altered regulation or expression of the endogenous protein and by way of virally-encoded kinase genes.
Combination of dasatinib and blinatumomab offers effective treatment for older Ph+ ALL patients

Combination of dasatinib and blinatumomab offers effective treatment for older Ph+ ALL patients

Researchers discover way to reverse brain aging caused by COVID-19

Researchers discover way to reverse brain aging caused by COVID-19

Senolytics show promise in combating brain aging and COVID-19 neuropathology

Senolytics show promise in combating brain aging and COVID-19 neuropathology

Senolytic therapy in mild Alzheimer’s disease shows safety in phase I trial

Senolytic therapy in mild Alzheimer’s disease shows safety in phase I trial

Phase I trial of senolytic therapy shows promise in Alzheimer's disease

Phase I trial of senolytic therapy shows promise in Alzheimer's disease

New research pinpoints key culprit behind brain cancer metastasis in children

New research pinpoints key culprit behind brain cancer metastasis in children

Senolytics could be a beneficial therapeutic for COVID neuropathology

Senolytics could be a beneficial therapeutic for COVID neuropathology

Study describes the variations in drug response across genetic subtypes of childhood leukemia

Study describes the variations in drug response across genetic subtypes of childhood leukemia

Discovery of cellular uptake pathway for larger molecules can be harnessed to create new drugs

Discovery of cellular uptake pathway for larger molecules can be harnessed to create new drugs

New combination of drugs effective against T-cell acute lymphoblastic leukemia

New combination of drugs effective against T-cell acute lymphoblastic leukemia

Drug combination without chemotherapy can be effective in treating older patients with Ph+ ALL

Drug combination without chemotherapy can be effective in treating older patients with Ph+ ALL

Potential association between senescence and aging in COVID-19

Potential association between senescence and aging in COVID-19

Clearing old, dysfunctional cells in fat alleviates diabetes

Clearing old, dysfunctional cells in fat alleviates diabetes

Cancer drugs could be repurposed as potential therapies for Alzheimer's disease

Cancer drugs could be repurposed as potential therapies for Alzheimer's disease

Celastrol shows potential anti-SARS-CoV-2 activity

Celastrol shows potential anti-SARS-CoV-2 activity

Study sheds light on potential new treatment approach in AML patients

Study sheds light on potential new treatment approach in AML patients

YAP signal pathway plays a vital role in the onset of head-and-neck cancer

YAP signal pathway plays a vital role in the onset of head-and-neck cancer

First randomized clinical trial compares targeted therapies for acute lymphoblastic leukemia

First randomized clinical trial compares targeted therapies for acute lymphoblastic leukemia

Researchers discover new chemical weapon to fight against cancer

Researchers discover new chemical weapon to fight against cancer

Physicians more likely to prescribe drugs of manufacturers who paid them money

Physicians more likely to prescribe drugs of manufacturers who paid them money