Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

PhoreMost appoints Professor Peter Parker and Dr Jason Imbriglio to Scientific Advisory Board

PhoreMost Ltd. announced Professor Peter Parker and Dr Jason Imbriglio as members of its Scientific Advisory Board (SAB).

From PhoreMost 17 Jul 2023

Insilico Medicine and MIKADO team up to find new treatments for cystinosis

A team led by researchers at the Mechanisms of Inherited Kidney Disorders (MIKADO) group at the University of Zurich (Zurich, Switzerland) has used Insilico Medicine's generative artificial intelligence (AI) target discovery engine, PandaOmics, to identify actionable drug targets for the lysosomal storage disease cystinosis and to validate them in preclinical models of the disease.

14 Jul 2023

AI-powered drug discovery offers hope for cystinosis patients

Artificial intelligence is becoming increasingly important in drug discovery. Advances in the use of Big Data, learning algorithms and powerful computers have now enabled researchers at the University of Zurich (UZH) to better understand a serious metabolic disease.

14 Jul 2023

Study finds highly specific polygenic signatures across multidimensional symptoms of bipolar disorder

Researchers analyzed the relationships between polygenic liability for bipolar disorder, schizophrenia, and major depressive disorder.

13 Jul 2023

Amplified Sciences secures $400,000 grant to develop pancreatic cancer diagnostic test

Health care providers and their patients could know with greater confidence whether pancreatic cysts are benign or potentially malignant, and if surgery is required to remove them, by using a new diagnostic test currently in development.

12 Jul 2023

Australian rainforest remedies: Scientists explore bioactive plant compounds as potential anti-neuroinflammatory agents

Research discusses the process of discovering anti-inflammatory and neuroprotective drugs from medicinal plants found in the Australian rainforest. It focuses on the pathways from the discovery of bioactive plants to the validation in an appropriate neuro-inflammatory mouse model, using some examples from their current research.

9 Jul 2023

The Spectrum CE System: A capillary electrophoresis instrument for the forensic laboratory workflow

In this Interview, NewsMedical talks to Ben Krenke about the Spectrum CE system for Forensic laboratory workflow.

From Promega Corporation 7 Jul 2023

NOSTER & Science Microbiome Prize winner illuminates how "silent flagellins" from commensal microbiota evade innate immunity

Sara Clasen is the 2023 winner of the NOSTER & Science Microbiome Prize for her work in illuminating how "silent flagellins" from commensal microbiota evade a host's innate immunity.

6 Jul 2023

Metrion Biosciences expands senior leadership team with appointments of Dr Robert Kirby as COO and Dr Edward Stevens as CSO

Metrion Biosciences Limited (“Metrion”), is a specialist ion channel contract research and drug discovery company.

From Metrion Biosciences Limited 6 Jul 2023

New protein found to help melanoma evade the immune system

New research from Sanford Burnham Prebys has helped explain how melanoma evades the immune system and may guide the discovery of future therapies for the disease.

5 Jul 2023

Study identifies role of ROR1 in pancreatic cancer metastasis

Tumor-initiating cells, or cancer stem cells, are gaining attention in cancer therapy, as they can travel through the body and cause cancerous tumors at other sites through metastasis.

5 Jul 2023

Next step in Sartorius partnership finalized: Several subsales and distribution agreements as well as R&D project agreements have been signed

During May and June 2023 several sub-sales and distribution agreements were signed between Sartorius and BICO companies CELLINK, Advanced BioMatrix (ABM) and Dispendix.

From BICO 5 Jul 2023

Camena Bioscience closes $10m Series A financing as demand for DNA synthesis technology increases

Camena Bioscience, a synthetic biology company providing genes to the pharmaceutical and biotechnology industries.

From Camena Bioscience 3 Jul 2023

Multiple drug targets for the treatment of influenza identified using AI program

Poolbeg Pharma, a clinical-stage biopharmaceutical company focusing on infectious and other prevalent diseases with a high unmet medical need, announces a significant breakthrough in its world first influenza Artificial Intelligence ('AI') Programme with CytoReason.

1 Jul 2023

Study finds age-dependent genetic mutations linked to treatment-resistant breast cancer

A study led by researchers at Sanford Burnham Prebys has found that in young women, certain genetic mutations are associated with treatment-resistant breast cancer.

30 Jun 2023

UTHSC College of Pharmacy ranked No. 6 in annual research funding from the NIH

The College of Pharmacy at the University of Tennessee Health Science Center is now ranked No. 6 in annual research funding from the National Institutes of Health, according to a new listing published by the American Association of Colleges of Pharmacy of its approximately 140 member institutions.

29 Jun 2023

Study shows promising prospects for automating 3D-DSRT in drug testing

The June 2023 issue of SLAS Discovery contains one review article, five full-length articles and two technical briefs covering spheroid models, 3D cell high-throughput screening (HTS) applications for treating Alzheimer's and other drug discovery research.

29 Jun 2023

eTRANSAFE: European project to share data on the safety of medicines

eTRANSAFE, the European project to share data on the safety of medicines, has come to fruition. On a single platform, the project has integrated data from more than 10,000 pharmacological studies by reference pharmaceutical companies, from a dozen databases that amass public and private information of clinical and preclinical studies.

29 Jun 2023

Novel computational tool helps analyze complex genetic regions

GeneDx (Nasdaq: WGS), a leader in delivering improved health outcomes through genomic and clinical insights, today published a paper in Nature Methods, titled "Multiscale analysis of pangenomes enables improved representation of genomic diversity for repetitive and clinically relevant genes," in which researchers developed a new computational tool, the PanGenome Research-Tool Kit (PGR-TK), for scalable analysis of clinically relevant genes that were previously too complex to analyze.

27 Jun 2023

A new approach for the synthesis of pharmaceutically relevant fluorinated phenanthridines

Phenanthridines are heterocyclic compounds consisting of two six-membered benzene rings fused to a six-membered ring containing nitrogen.

26 Jun 2023

Drug Discovery News and Research

Further Reading

PhoreMost appoints Professor Peter Parker and Dr Jason Imbriglio to Scientific Advisory Board

Insilico Medicine and MIKADO team up to find new treatments for cystinosis

AI-powered drug discovery offers hope for cystinosis patients

Study finds highly specific polygenic signatures across multidimensional symptoms of bipolar disorder

Amplified Sciences secures $400,000 grant to develop pancreatic cancer diagnostic test

Australian rainforest remedies: Scientists explore bioactive plant compounds as potential anti-neuroinflammatory agents

The Spectrum CE System: A capillary electrophoresis instrument for the forensic laboratory workflow

NOSTER & Science Microbiome Prize winner illuminates how "silent flagellins" from commensal microbiota evade innate immunity

Metrion Biosciences expands senior leadership team with appointments of Dr Robert Kirby as COO and Dr Edward Stevens as CSO

New protein found to help melanoma evade the immune system

Study identifies role of ROR1 in pancreatic cancer metastasis

Next step in Sartorius partnership finalized: Several subsales and distribution agreements as well as R&D project agreements have been signed

Camena Bioscience closes $10m Series A financing as demand for DNA synthesis technology increases

Multiple drug targets for the treatment of influenza identified using AI program

Study finds age-dependent genetic mutations linked to treatment-resistant breast cancer

UTHSC College of Pharmacy ranked No. 6 in annual research funding from the NIH

Study shows promising prospects for automating 3D-DSRT in drug testing

eTRANSAFE: European project to share data on the safety of medicines

Novel computational tool helps analyze complex genetic regions

A new approach for the synthesis of pharmaceutically relevant fluorinated phenanthridines

Drug Discovery - Second Edition eBook

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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