The June 2023 issue of SLAS Discovery contains one review article, five full-length articles and two technical briefs covering spheroid models, 3D cell high-throughput screening (HTS) applications for treating Alzheimer's and other drug discovery research.
In drug discovery, 3D cell models have emerged as more physiologically relevant than traditional 2D cell cultures in ex vivo models. As the complexity of patient-derived primary 3D cell cultures increases, so does the need for a supportive matrix for facilitating their formation.
Featured in this month's issue is the article "Comparison of two supporting matrices for patient-derived cancer cells in 3D drug sensitivity and resistance testing assay," by Feodoroff, et al, which explores the comparison between animal-derived matrix (Matrigel) and animal-free matrix (GrowDex) for developing spheroids from HepG2 cells in drug screening assays. Through a proof-of-concept study, the authors demonstrated that both matrices effectively support the growth of spheroids derived from patient cells (PDCs) for 3D drug sensitivity and resistance testing (3D-DSRT).
These findings offer promising prospects for automating 3D-DSRT in drug testing, encompassing cell lines and PDCs.
Read this original research article to see what the authors suggest as potential improvements to 3D-DSRT in drug testing, along with more research articles in the June issue of SLAS Discovery.
The June issue of SLAS Discovery includes these additional articles:
Feodoroff, M., et al. (2023) Comparison of two supporting matrices for patient-derived cancer cells in 3D drug sensitivity and resistance testing assay (3D-DSRT). SLAS Discovery. doi.org/10.1016/j.slasd.2023.03.002.