Endothelial cell News and Research

RSS

New insights can pave the way for targeted therapies to fight blood clots in COVID-19 patients

Driven by the mystery of the blood clots reported in both living and deceased COVID-19 patients, researchers from Shoolini University, India, dig deeper into the pathogenesis of COVID-19 and other similar viral diseases, looking for ways in which these clots could be formed.

24 Jun 2021

Study shows activation of CD16+ T-cells contribute to severe COVID-19 illness

Do T-cells play a protective immune role, or are they responsible for severe COVID-19 illness?

21 Jun 2021

Study may offer an unexpected pathway for targeted treatment of brain tumors

In a new study led by Yale Cancer Center, researchers show the nucleoside transporter ENT2 may offer an unexpected path to circumventing the blood-brain barrier (BBB) and enabling targeted treatment of brain tumors with a cell-penetrating anti-DNA autoantibody.

15 Jun 2021

Lymphangiogenesis predicts favorable outcomes to immunotherapy

Oncotarget published "Mutually exclusive lymphangiogenesis or perineural infiltration in human skin squamous-cell carcinoma" which reported that although tumor-associated lymphangiogenesis correlates with metastasis and poor prognosis in several cancers, it also supports T cell infiltration into the tumor and predicts favorable outcome to immunotherapy.

8 Jun 2021

Novel insights can open doors to combating clotting-related problems in COVID-19

Researchers scour what is known to come up with a hypothesis of why blood clots can be a major problem in COVID-19

4 Jun 2021

Direct action of SARS-CoV-2 on organs may lead to exacerbated inflammatory response in pediatric patients

Besides common symptoms such as fever, cough and respiratory distress, some children have an atypical form of COVID-19 known as multisystem inflammatory syndrome in children (MIS-C), characterized by persistent fever and inflammation of several organs, such as the heart and intestines, as well as the lungs to a lesser extent.

1 Jun 2021

Decreasing activity of ZMPSTE24 protease with age and comorbidities may make elderly COVID-19 patients vulnerable

Studies have shown that circulating levels of PAI-1, the coagulation cascade activator, are considerably higher in COVID-19 patients with severe respiratory illness compared to patients with bacterial-sepsis and acute respiratory distress syndrome (ARDS). Hence the increase in PAI-1 levels is recognized as an early marker of endothelial dysfunction in COVID-19 patients.

23 May 2021

Are COVID-19-related complications in children explained by abnormal immune responses?

A common theme in reports on COVID-19 around the world has been the large number of children who have not been infected or shown signs of disease. However, though the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes less acute infection in this age group, it is associated with a severe immune-mediated multisystemic illness called multisystem inflammatory syndrome in children (MIS-C).

20 May 2021

Antithrombotic endothelial dysfunction is prevented by Tie2 activation in severe COVID-19

Researchers from the US recently assessed if severe COVID-19 is linked to procoagulant dysfunction of the endothelium and changes in the Tie2-angiopoietin axis. They assessed circulating endothelial markers in a study cohort of 98 patients with mild, moderate, or severe COVID-19. This study is published on the medRxiv* preprint server.

19 May 2021

Penn State researchers develop a way to study microenvironment of breast cancer in 3D

Cancerous tumors thrive on blood, extending their roots deep into the fabric of the tissue of their host. They alter the genetics of surrounding cells and evolve to avoid the protective attacks of immune cells.

4 May 2021

Can SARS-CoV-2’s impairment of endothelium cause vascular disease?

The study, published in the journal Circulation Research, suggests that COVID-19 is not only a respiratory disease but also a vascular disease. It highlights how the virus attacks the vascular system, causing endothelial impairment.

4 May 2021

New exosome-coated stent repairs damaged tissue, heals vascular injury

Researchers from North Carolina State University have developed an exosome-coated stent with a "smart-release" trigger that could both prevent reopened blood vessels from narrowing and deliver regenerative stem cell-derived therapy to blood-starved, or ischemic, tissue.

6 Apr 2021

How SARS-CoV-2 proteins affect vascular functionality

The study, published on the pre-print server medRxiv, can pinpoint and isolate how each of the SARS-CoV-2 proteins independently affects the endothelial response and directly gauge endothelial functionality.

3 Mar 2021

Endothelial SARS-CoV-2 infection induces proinflammatory responses without supporting viral amplification, finds study

A team of scientists from Australia and Brazil recently investigated the involvement of endothelial cells in the pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

18 Feb 2021

Higher proportion of male children develop COVID-19-related Multisystem Inflammatory Syndrome, finds study

Previous studies about COVID-19 have shown that the illness is often more severe in men than women. However, there is limited data available for the pediatric population. Though children and adolescents are at a lower risk of developing severe illness, some may experience severe symptoms. In some cases, children develop complications, including the multisystem inflammatory syndrome in children (MIS-C). Researchers report that a higher percentage of male children developed MIS-C and died.

11 Feb 2021

Cell-selective nanotherapy can help treat atherosclerotic plaques

Percutaneous coronary intervention (PCI), commonly known as angioplasty with a stent, opens clogged arteries and saves lives. Despite its benefit in treating atherosclerosis that causes coronary artery disease, this common minimally-invasive procedure still poses severe complications for some patients.

11 Feb 2021

Study identifies major flaws in iBMEC-based models of the blood-brain barrier

A type of cell derived from human stem cells that has been widely used for brain research and drug development may have been leading researchers astray for years, according to a study from scientists at Weill Cornell Medicine and Columbia University Irving Medical Center.

9 Feb 2021

In vitro human blood-brain barrier model found to have a critical flaw

Cells used to study the human blood brain barrier in the lab aren't what they seem, throwing nearly a decade's worth of research into question, a new study from scientists at Columbia University Vagelos College of Physicians and Surgeons and Weill Cornell Medicine suggests.

8 Feb 2021

Elevated ACE2 and inflammation levels increase risk for pregnant women infected with SARS-CoV-2

Among the hundred million or so cases of coronavirus disease 2019 (COVID-19) that have occurred since the pandemic began, pregnant women have been a conspicuous risk group. However, the exact nature of the risk they and their fetuses face, and the mechanism by which it operates, is far from clear.

2 Feb 2021

Researchers develop a simple and efficient way to generate hemogenic endothelial cells

Pioneering research into how our bodies manufacture the cells that make blood has moved us closer to regrowing tissues and organs. The findings also may let doctors grow the cells for transplantation into people to battle cancer, blood disorders and autoimmune diseases.

28 Jan 2021