Exhaustion News and Research

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New CAR T cells offer controlled treatment for solid tumors

Ludwig Cancer Research scientists have devised new types of chimeric antigen-receptor (CAR) T cells-;a type of cancer immunotherapy-;that can be switched on to varying degrees of intensity and then switched off on demand with existing drugs.

21 Oct 2024

Gene editing enhances immunotherapy success by preventing T-cell exhaustion

Immunotherapy, using a patient's own immune system to treat disease, has shown promise in some patients with cancer but has not worked in most.

12 Oct 2024

Innovative immunotherapy harnesses natural killer T cells to combat solid tumors

In the fight against cancer, chimeric antigen receptor T cell (CAR-T) therapy has achieved notable success in treating blood cancers. However, it has been largely ineffective against solid tumors.

7 Oct 2024

Combining apple peel and mistletoe extracts to boost muscle health and endurance

Research shows that mistletoe and apple peel extracts improve muscle health and endurance, suggesting a natural approach to combat age-related muscle decline.

1 Oct 2024

Researchers identify a protein that recharges T cells for long-lasting cancer remission

Research shows Fc–IL-4 revitalizes exhausted CD8+ T cells, boosting antitumor responses and highlighting the potential of combining type 1 and type 2 immunity.

30 Sep 2024

A week of intense cycling may burn abdominal fat without major weight loss, study finds

A week of extreme cycling significantly decreased visceral adiposity in middle-aged cyclists, emphasizing the role of exercise in body composition management.

23 Sep 2024

Scientists develop novel technique to combat T cell exhaustion

Fighting cancer is exhausting for T cells. Hostile tumor microenvironments can drain their mitochondrial activity, leading to a condition known as T cell exhaustion. This phenomenon also hinders adoptive cell therapies, in which healthy, tumor-targeting T cells are infused into patients with cancer. A novel method to boost mitochondrial activity and charge up T cells is needed.

14 Sep 2024

New discovery offers hope for overcoming CAR-T cell therapy resistance

Mayo Clinic researchers mined the molecular foundations of cancer and uncovered a new reason chimeric antigen receptor (CAR-T cell therapy) fails in some patients.

12 Sep 2024

In Montana, 911 calls reveal impact of heat waves on rural seniors

Missoula is one of Montana's largest cities but is surrounded by rural mountain communities where cattle ranching is king.

12 Sep 2024

World champion marathon runner’s life study highlights benefits and risks of life-long endurance exercise

Decades of intense marathon training have preserved heart function in a 77-year-old, highlighting benefits and risks of extreme endurance exercise.

11 Sep 2024

High-precision X-rays uncover the mechanics of neck pain

Learning new languages, sending emails, attending a virtual class, or speaking to loved ones halfway around the world are just some of the tasks accomplished by touching a button on a smartphone. Unfortunately, the ease and convenience of modern devices have also come with a painful crick in the neck. The sedentary nature of work and prolonged use of hand-held devices and computers have contributed to a sharp increase in neck pain.

5 Sep 2024

CD4 T cells found to be key players in tuberculosis defense

The body's first line of defense against tuberculosis (TB) involves immune cells that suppress lung inflammation instead of activating it, reported University of Pittsburgh and the Ragon Institute of Mass General, MIT, and Harvard scientists today in Immunity.

29 Aug 2024

Study reveals metabolic switch crucial for memory T cell formation and cancer immunity

A Ludwig Cancer Research study has identified a metabolic switch in the immune system's T cells that is essential to the generation of memory T cells-;which confer lasting immunity to previously encountered pathogens-;and a T cell subtype found in tumors that drives anti-tumor responses during immunotherapy.

23 Aug 2024

Two studies uncover how immunotherapies work together to activate immune responses in melanoma

Two studies published in the latest issue of the journal Cell by University of Pittsburgh researchers uncover how immunotherapies targeting the immune checkpoints PD1 and LAG3 work together to activate immune responses.

13 Aug 2024

Discovery of progenitor exhausted T cells offers hope for cancer patients

Tumor immunotherapy leverages the body's immune system to target and eradicate cancer cells, offering a crucial treatment for patients unresponsive to surgery or conventional therapies. Despite its potential, the effectiveness of immunotherapy is often hindered by T cell exhaustion within the tumor microenvironment, leading to diminished immune response and tumor progression. Based on these challenges, exploring the role of progenitor exhausted T cells (Tpex) in overcoming immune resistance is essential for advancing immunotherapeutic strategies and improving clinical outcomes.

8 Aug 2024

MD Anderson and collaborators initiate space project to explore T cell behavior in microgravity

The University of Texas MD Anderson Cancer Center and collaborators are initiating a research project that will send T cells to the International Space Station (ISS) to study the effects of prolonged microgravity on cell differentiation, activation, memory and exhaustion.

31 Jul 2024

Exhaustion News and Research

New CAR T cells offer controlled treatment for solid tumors

Gene editing enhances immunotherapy success by preventing T-cell exhaustion

Innovative immunotherapy harnesses natural killer T cells to combat solid tumors

Combining apple peel and mistletoe extracts to boost muscle health and endurance

Researchers identify a protein that recharges T cells for long-lasting cancer remission

A week of intense cycling may burn abdominal fat without major weight loss, study finds

Scientists develop novel technique to combat T cell exhaustion

New discovery offers hope for overcoming CAR-T cell therapy resistance

In Montana, 911 calls reveal impact of heat waves on rural seniors

World champion marathon runner’s life study highlights benefits and risks of life-long endurance exercise

High-precision X-rays uncover the mechanics of neck pain

CD4 T cells found to be key players in tuberculosis defense

Study reveals metabolic switch crucial for memory T cell formation and cancer immunity

Two studies uncover how immunotherapies work together to activate immune responses in melanoma

Discovery of progenitor exhausted T cells offers hope for cancer patients

MD Anderson and collaborators initiate space project to explore T cell behavior in microgravity

Hydrogen-rich gas inhalation reduces exercise-induced fatigue and enhances performance

Study reveals moderate burden of post-COVID conditions in primary care

New study helps better understand the pathology of fatty liver disease MASH

Virtual reality training to combat implicit bias in maternal health care

Decoding Cannabis: Differentiating Hemp and Marijuana

Deciphering the Microbiome with The Microsetta Initiative

Leveraging the power of automation to boost research

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