Exonuclease News and Research

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Genome editing techniques based on bacterial-artificial-chromosome in herpesvirus research

In a recent study published in the Microorganisms journal, researchers in China reviewed the uses of bacterial-artificial-chromosome (BAC)-based genome editing techniques in herpesvirus research.

28 Feb 2023

Molnupiravir-related mutational signatures among COVID-19 patients

Researchers explore a mutational signature related to molnupiravir in SARS-CoV-2 sequencing datasets.

3 Feb 2023

Preclinical study shows the therapeutic value of kinetin against SARS-CoV-2

Researchers investigated the ability of kinetin (N6-furfurylaminopurine, MB-905) to inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proliferation in vitro.

17 Jan 2023

RNA-dependent RNA polymerase inhibitors in COVID-19 therapy

A new paper reviews current knowledge of RdRp inhibitors that could be developed further to provide broadly effective antivirals against SARS-CoV-2 in particular and CoVs in general.

10 Oct 2022

Exploring remdesivir resistance in COVID-19-infected transplant recipients

In a new study, researchers assessed the remdesivir resistance developed in coronavirus disease 2019 (COVID-19)-infected transplant recipients.

29 Sep 2022

Is monkeypox a global public-health emergency?

A summary of available knowledge on the monkeypox virus including pathogenicity, risk to the human population, and strategies that can help limit its spread.

20 Jul 2022

Molnupiravir does not induce resistance mutations in SARS-CoV-2 genome

A new study has pointed out that Molnupiravir treatment increases the ratio of transition to transversion mutations in COVID-19 patients and that the treatment does not appear to induce resistance mutations in the SARS-CoV-2 genome.

19 Jul 2022

The potential of circular RNA COVID-19 vaccines

A new MedComm study describes the potential use of circular ribonucleic acid COVID-19 vaccines.

17 Jul 2022

Remdesivir resistance in renal transplant patients with long COVID-19

A new study has reported two renal transplant cases, in which individuals, after being exposed to remdesivir, developed a resistance to the drug.

1 Jul 2022

The frequency and nature of RNA errors in both SARS-CoV-2 and its vaccine

A recent article demonstrated that SARS-CoV-2 mutants and vaccine variability stem from ribonucleic acid polymerase inaccuracy.

6 Jun 2022

Nanotechnology enhanced DNA-chip for SARS-CoV-2 detection with variant differentiation

Researchers differentiated between SARS-CoV-2 variants using nanotechnology.

26 May 2022

Is COVID-19 on the verge of ending?

Researchers explore the changes arising in SARS-CoV-2 over time.

21 Mar 2022

Novel targets to inhibit SARS-CoV-2 variants

A new study identified additional targets on SARS-CoV-2 proteins to prevent the emergence of new SARS-CoV-2 variants of concern.

16 Mar 2022

Study reveals the potential of novel antiviral drug combinations to stop COVID-19 spread

Researchers from Columbia Engineering, Fiocruz's Center for Technological Development in Health and the Oswaldo Cruz Institute in Brazil, Memorial Sloan Kettering Cancer Center, and Rockefeller University recently reported that, by combining inhibitors of polymerases and exonucleases--enzymes that allow SARS-CoV-2 to reproduce--they were able to reduce SARS-CoV-2 replication 10 times more than when using just the polymerase inhibitors.

7 Mar 2022

Study identifies current mechanism of action behind reduced severity of Omicron variant COVID-19 infection

New research shows evidence that the Omicron variant is less severe compared to the Delta variant.

6 Jan 2022

Emergence of a new SARS-CoV-2 variant from Southern France

A new study has described the emergence of another new SARS-CoV-2 variant from south-eastern France with Cameroonian origin.

6 Jan 2022

Impact of the rapid spread of the SARS-CoV-2 Omicron variant in Southern Africa

A new study has focused on the genomic profile and early transmission dynamics of Omicron. This study revealed the dominance of the Omicron variant in regions with high levels of population immunity.

23 Dec 2021

The antiviral potential of 4′-fluorouridine as an oral treatment against RSV and SARS-CoV-2

New research reports 4’-Fluorouridine (4′-FlU) as an oral antiviral against RSV and SARS-CoV-2.

7 Dec 2021

Ensemble cryo-electron microscopy uncovers conformational states of the nsp13 helicase of SARS-CoV-2

With this background, the goal of a new study published on the bioRxiv* preprint server was to use cryo-electron microscopy to investigate the nsp13 helicase conformational states in order to gain insights of how nsp13 functions during viral transcription/replication.

16 Nov 2021

GIST researchers unravel coordination mechanism of base excision repair

A new study by researchers from the Gwangju Institute of Science and Technology in the Republic of Korea has revealed the mechanism of DNA repair by enzymes exonuclease III and polymerase I by utilizing single molecule fluorescence resonance energy transfer (smFRET)-enabled dynamic observation.

14 Sep 2021