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MIT chemists discover how changes in a shape-shifting receptor trigger cell growth

Receptors found on cell surfaces bind to hormones, proteins, and other molecules, helping cells respond to their environment.

6 Jul 2022

Paxlovid resistance associated with SARS-CoV-2 3CLpro mutations

In a recent study published in the bioRxiv* preprint server, researchers at the Medical University of Innsbruck assessed the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 3CLpro mutations responsible for Paxlovid resistance. The 3-chymotrypsin-like protease (3CLPro), or main protease (Mpro), is the main protease found in coronaviruses.

6 Jul 2022

Scientists discover how a protein and enzymes interact to allow hepatitis A virus replication

The viral replication cycle is crucial for a virus to spread inside the body and cause disease. Focusing on that cycle in the hepatitis A virus (HAV), UNC School of Medicine scientists discovered that replication requires specific interactions between the human protein ZCCHC14 and a group of enzymes called TENT4 poly(A) polymerases.

4 Jul 2022

Enteric viruses found to transmit through the salivary route

Researchers reported on the productive and persistent infection of salivary glands (SGs) by enteric viruses, with oral cavity titers similar to intestinal titers.

4 Jul 2022

New K+-sensitive dual-mode imaging probe for diagnosis of tumor malignancy

Tumor malignancy identification plays an essential role in clinical management of cancer. Currently, biopsy is the gold standard for malignancy identification in most tumor cases, it is, however, invasive that can cause great discomfort to patients, and potentially increase the risk of distant metastases due to the complex sampling process.

1 Jul 2022

Somatic hypermutations found to enhance humoral immunity against SARS-CoV-2 variants

Researchers explored the molecular basis for increased immunity against heterologous SARS-CoV-2 strains after repeated antigen exposures.

1 Jul 2022

The identification and characterization of a thermophilic Cas13a ortholog highly active at the temperatures required for RT-LAMP

Researchers developed a new detection assay for SARS-CoV-2.

1 Jul 2022

SARS-CoV-2 can evade Paxlovid by multiple mechanisms

In a recent article posted to the bioRxiv* preprint server, researchers at Rutgers, the State University of New Jersey, the University of South Florida, and the Catholic University of America demonstrated that the natural severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro) mutations result in nirmatrelvir resistance.

30 Jun 2022

Optical fiber holds promise for use in deep-tissue studies of patients’ brains with Alzheimer’s disease

An optical fiber as thin as a strand of hair holds promise for use in minimally invasive deep-tissue studies of patients' brains that show the effects Alzheimer's disease and other brain disorders.

30 Jun 2022

A fast, highly sensitive, point-of-care RT-LAMP and CRISPR/Cas12a assay for the detection of SARS-CoV-2

Researchers used isothermal amplification with CRISPR-Cas12a to detect SARS-CoV-2.

30 Jun 2022

Potent antibody with a novel neutralization mechanism against SARS-CoV-2 variants

In a recent study posted to the bioRxiv* pre-print server, researchers in the United States described a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-neutralizing monoclonal antibody (mAb) SP1-77 that broadly neutralized its multiple variants of concern (VOCs).

28 Jun 2022

Shapeshifting behavior of E. coli may offer clues to combat urinary tract infections

Urinary tract infections are both very common and potentially very dangerous. More than half of all Australian women will suffer from a UTI in their lifetime, and nearly one in three women will have an infection requiring treatment with antibiotics before the age of 24.

28 Jun 2022

Researchers analyze potential of niclosamide as a SARS-CoV-2 treatment

A recent study posted to the bioRxiv* preprint server assessed whether niclosamide could be employed in coronavirus disease 2019 (COVID-19) therapy.

28 Jun 2022

Recombinant SARS-CoV-2 harboring double reporters for COVID-19 surveillance

In a recent article posted to the bioRxiv* preprint server, researchers at Texas Biomedical Research Institute, Georgia State University, and the University of Alabama at Birmingham developed a bireporter-expressing recombinant severe acute respiratory syndrome coronavirus 2 (rSARS-CoV-2) for tracking SARS-CoV-2 infection.

27 Jun 2022

Lipid-peptide nanocomplexes offer new mRNA platform

A new paper reports the methodical development of lipid-peptide nanocomplexes as a delivery vehicle for messenger ribonucleic acid molecules to the tumor cell, in vitro and in vivo.

27 Jun 2022

Study unveils a precise model for the stinging organelle of starlet sea anemone

Summertime beachgoers are all too familiar with the painful reality of a jellyfish sting. But how do the stinging cells of jellyfish and their coral and sea anemone cousins actually work? New research from the Stowers Institute for Medical Research unveils a precise operational model for the stinging organelle of the starlet sea anemone, Nematostella vectensis.

23 Jun 2022

SARS-CoV-2 evades natural killer cell cytotoxic responses

In a recent study posted to the bioRxiv* preprint server, researchers at Stanford University School of Medicine revealed the mechanism via severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) escapes natural killer (NK) cell cytotoxic reactions.

22 Jun 2022

SARS-CoV-2 variants of concern exhibit divergent interactions with host proteases

In a recent study posted to the bioRxiv* preprint server, researchers at Weill Cornell Medical College assessed the cleavability of the spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) and related coronaviruses by several proteases of the host.

19 Jun 2022

New sensor accurately determines the human saliva pH

Chemists at the Ural Federal University have created a sensor for determining the human saliva pH. This is a fluorophore with strong and stable emission, which picks up the smallest fluctuations in the pH(tenths) in biological fluids.

16 Jun 2022

Bruker introduces enhanced 3D holographic stimulation for optogenetics on its Ultima 2Pplus multiphoton microscope

Bruker Corporation today announced the release of the NeuraLight 3D Ultra™ module to support advanced neuroscience and optogenetics research applications on Bruker’s Ultima multiphoton microscopes.

From Bruker Nano Surfaces and Metrology 16 Jun 2022

Fluorescence News and Research

MIT chemists discover how changes in a shape-shifting receptor trigger cell growth

Paxlovid resistance associated with SARS-CoV-2 3CLpro mutations

Scientists discover how a protein and enzymes interact to allow hepatitis A virus replication

Enteric viruses found to transmit through the salivary route

New K+-sensitive dual-mode imaging probe for diagnosis of tumor malignancy

Somatic hypermutations found to enhance humoral immunity against SARS-CoV-2 variants

The identification and characterization of a thermophilic Cas13a ortholog highly active at the temperatures required for RT-LAMP

SARS-CoV-2 can evade Paxlovid by multiple mechanisms

Optical fiber holds promise for use in deep-tissue studies of patients’ brains with Alzheimer’s disease

A fast, highly sensitive, point-of-care RT-LAMP and CRISPR/Cas12a assay for the detection of SARS-CoV-2

Potent antibody with a novel neutralization mechanism against SARS-CoV-2 variants

Shapeshifting behavior of E. coli may offer clues to combat urinary tract infections

Researchers analyze potential of niclosamide as a SARS-CoV-2 treatment

Recombinant SARS-CoV-2 harboring double reporters for COVID-19 surveillance

Lipid-peptide nanocomplexes offer new mRNA platform

Study unveils a precise model for the stinging organelle of starlet sea anemone

SARS-CoV-2 evades natural killer cell cytotoxic responses

SARS-CoV-2 variants of concern exhibit divergent interactions with host proteases

New sensor accurately determines the human saliva pH

Bruker introduces enhanced 3D holographic stimulation for optogenetics on its Ultima 2Pplus multiphoton microscope

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Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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