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Researchers reveal how genome-editing tool works as 'guided missile' to correct errors in genetic code

Researchers from the Broad Institute and MIT have teamed up with colleagues from the University of Tokyo to form the first high definition picture of the Cas9 complex - a key part of the CRISPR-Cas system used by scientists as a genome-editing tool to silence genes and probe the biology of cells. Their findings, which are reported this week in Cell, are expected to help researchers refine and further engineer the tool to accelerate genomic research and bring the technology closer to use in the treatment of human genetic disease.

13 Feb 2014

Scientists take steps to identify genetic component to bipolar disorder

Scientists know there is a strong genetic component to bipolar disorder, but they have had an extremely difficult time identifying the genes that cause it. So, in an effort to better understand the illness's genetic causes, researchers at UCLA tried a new approach.

13 Feb 2014

Novogene purchases HiSeq X Ten sequencing system from Illumina

Illumina, Inc. (NASDAQ:ILMN) today announced that Novogene (www.novogene.cn), a leading genomics service provider based in Beijing, China, purchased one HiSeq X Ten.

From Illumina, Inc. 13 Feb 2014

Study uncovers how gut bacteria metabolize complex dietary carbohydrates in fruits, vegetables

We are all aware of the health benefits of dietary fiber. But what is dietary fiber and how do we metabolize it?

13 Feb 2014

CHOP develops unique laboratory test to characterize genes that encode HLA molecules

Immunogenetics experts at The Children's Hospital of Philadelphia (CHOP) have developed a unique laboratory test to characterize the genes that encode HLA molecules. The test relies on faster, more comprehensive gene sequencing technology to type human leukocyte antigens (HLAs)--complex, highly variable proteins on cell surfaces that are essential to immune function.

13 Feb 2014

Researchers discover pre-leukemic stem cell that triggers relapse in patients with AML

Cancer researchers led by stem cell scientist Dr. John Dick have discovered a pre-leukemic stem cell that may be the first step in initiating disease and also the culprit that evades therapy and triggers relapse in patients with acute myeloid leukemia (AML).

13 Feb 2014

$Sage Science releases new SageELF technology for DNA and protein fractionation$

Sage Science releases new SageELF technology for DNA and protein fractionation

Sage Science, a developer of products for improving sample preparation processes in life science applications, today announced the release of its new SageELF technology for DNA and protein fractionation. This sample prep instrument will be especially useful for preserving precious samples and has applications in next-generation sequencing as well as bottom-up or top-down proteomics experiments.

12 Feb 2014

GenomOncology collaborates with RPCI to develop informatics solution for Next Generation Sequencing

GenomOncology today announced a collaboration with Roswell Park Cancer Institute (RPCI) to develop an informatics solution that enables the association of Next Generation Sequencing results with knowledge resources to define actionable mutations.

11 Feb 2014

Covaris introduces truXTRAC High Throughput FFPE DNA Extraction & Purification Kit at 2014 AGBT

Covaris, Inc. introduced the truXTRAC™ High Throughput FFPE DNA Extraction & Purification Kit at the 2014 Advances in Genome Biology and Technology (AGBT) meeting held in Marco Island, Florida.

11 Feb 2014

Rubicon Genomics introduces PicoPLEX DNA-seq Kits for use with Illumina NGS platforms

Rubicon Genomics, Inc. today announced the launch of its PicoPLEX DNA-seq Kits for use with Illumina next-generation sequencing (NGS) platforms. PicoPLEX's outstanding robustness and reproducibility have made it the worldwide standard for single-cell DNA amplification for microarray and PCR-based pre-implantation genetic screening and diagnosis. PicoPLEX DNA-seq now enables researchers and clinicians to access PicoPLEX technology for analyses conducted on Illumina NGS systems.

10 Feb 2014

Findings may help physicians choose precise treatments for women with advanced breast cancer

The first large-scale study testing all the DNA—the entire genome—of tumour cells from more than 400 women with advanced breast cancer has identified individuals with a good chance of benefiting from specific treatments already being tested in clinical trials.

10 Feb 2014

New study tracks spread of H5N1 variant in Egypt recently identified as major epicenter for virus

Since its first identification in Asia, highly pathogenic avian influenza-H5N1-has caused significant alarm in the scientific community. While the virus' primary target is birds-tens of millions have already died from it-it is capable of infecting mammals, including humans, causing serious illness and a frightening rate of mortality.

10 Feb 2014

Scientists develop new approach to design drugs from genome sequence

In research that could ultimately lead to many new medicines, scientists from the Florida campus of The Scripps Research Institute (TSRI) have developed a potentially general approach to design drugs from genome sequence. As a proof of principle, they identified a highly potent compound that causes cancer cells to attack themselves and die.

10 Feb 2014

Optogenetics technique allows scientists to control neurons' electrical activity

Optogenetics is a technique that allows scientists to control neurons' electrical activity with light by engineering them to express light-sensitive proteins. Within the past decade, it has become a very powerful tool for discovering the functions of different types of cells in the brain.

10 Feb 2014

Study identifies seven new genetic regions associated with type 2 diabetes

Seven new genetic regions associated with type 2 diabetes have been identified in the largest study to date of the genetic basis of the disease.

9 Feb 2014

Researchers identify histone proteins that may be key to generate induced totipotent stem cells

One major challenge in stem cell research has been to reprogram differentiated cells to a totipotent state. Researchers from RIKEN in Japan have identified a duo of histone proteins that dramatically enhance the generation of induced pluripotent stem cells (iPS cells) and may be the key to generating induced totipotent stem cells.

7 Feb 2014

Chinese scientists confirm world’s first case of human infection with new avian influenza virus

Scientists from China report in The Lancet on the world’s first confirmed case of human infection with a new avian influenza A H10N8 virus in a 73-year-old woman who died from the infection.

6 Feb 2014

Study: Sensitivity to pain could be altered by person's lifestyle and environment

Researchers at King's College London have discovered that sensitivity to pain could be altered by a person's lifestyle and environment throughout their lifetime. The study is the first to find that pain sensitivity, previously thought to be relatively inflexible, can change as a result of genes being switched on or off by lifestyle and environmental factors - a process called epigenetics, which chemically alters the expression of genes.

5 Feb 2014

Splicing findings offer lung cancer clues

Researchers from Spain have identified several new splicing events regulated by the oncogenic splicing factor SRSF1 in lung cancer, suggesting that their dysregulation is involved in the pathogenesis of the disease.

4 Feb 2014

Researchers use naturally occurring HIV variant to trace T cell lineage for 17 years

A team of researchers has reported a novel method for tracking CD4+ T cells in people infected with HIV. CD4+ T cells are critical for immune defense against an array of pathogens and are a primary target of HIV. In the study, researchers used a unique, replication-incompetent (defective) form of HIV identified in a patient in the early 1990s.

4 Feb 2014

Genome News and Research

Researchers reveal how genome-editing tool works as 'guided missile' to correct errors in genetic code

Scientists take steps to identify genetic component to bipolar disorder

Novogene purchases HiSeq X Ten sequencing system from Illumina

Study uncovers how gut bacteria metabolize complex dietary carbohydrates in fruits, vegetables

CHOP develops unique laboratory test to characterize genes that encode HLA molecules

Researchers discover pre-leukemic stem cell that triggers relapse in patients with AML

Sage Science releases new SageELF technology for DNA and protein fractionation

GenomOncology collaborates with RPCI to develop informatics solution for Next Generation Sequencing

Covaris introduces truXTRAC High Throughput FFPE DNA Extraction & Purification Kit at 2014 AGBT

Rubicon Genomics introduces PicoPLEX DNA-seq Kits for use with Illumina NGS platforms

Findings may help physicians choose precise treatments for women with advanced breast cancer

New study tracks spread of H5N1 variant in Egypt recently identified as major epicenter for virus

Scientists develop new approach to design drugs from genome sequence

Optogenetics technique allows scientists to control neurons' electrical activity

Study identifies seven new genetic regions associated with type 2 diabetes

Researchers identify histone proteins that may be key to generate induced totipotent stem cells

Chinese scientists confirm world’s first case of human infection with new avian influenza virus

Study: Sensitivity to pain could be altered by person's lifestyle and environment

Splicing findings offer lung cancer clues

Researchers use naturally occurring HIV variant to trace T cell lineage for 17 years

Genetics & Genomics - Second Edition eBook

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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