Glomerulonephritis News and Research

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Cellular and humoral responses and the safety of recombinant and inactivated SARS-CoV-2 vaccines in chronic kidney disease patients

Researchers investigated the B cell and humoral immune responses elicited against inactivated and recombinant SARS-CoV-2 vaccines and their safety profiles in patients with CKD.

8 Feb 2023

Japanese study reveals increase in incidence rates of renal replacement therapy attributed to nephrosclerosis

A new Japanese study reveals that the age-standardized incidence rates of end-stage kidney disease (ESKD) requiring renal replacement therapy (RRT) due to chronic glomerulonephritis and diabetic nephropathy has decreased, while rates due to nephrosclerosis have increased considerably between 2006 and 2020.

23 Dec 2022

Study finds low absolute risk of glomerular disease relapse associated with COVID-19 vaccination

Several reports have described a relapse of certain autoimmune kidney diseases in patients after they've received COVID-19 vaccines, but it's unclear if this association is real or a coincidence.

4 Nov 2022

Study shows glomerulonephritis after SARS-CoV-2 mRNA vaccination likely coincidental

In a recent study posted to the medRxiv* pre-print server, researchers assessed whether messenger ribonucleic acid (mRNA)-based coronavirus disease 2019 (COVID-19) vaccines increase the incidence of glomerulonephritis against the null hypothesis stating any observed temporal association between the two phenomena was purely coincidental.

26 May 2022

Assessing the association of COVID-19 and Immunoglobulin A vasculitis in children

In a recent study posted to the Research Square* preprint server, researchers conducted a systematic review to investigate any association between immunoglobulin A (IgA) vasculitis and coronavirus disease 2019 (COVID-19) in children.

8 Feb 2022

Study reports safety, efficacy of targeted treatment for IgA nephropathy

IgA nephropathy (IgAN) is a chronic kidney disease occurring in young adults and is one of the most common reasons for kidney transplantation in this age group.

7 Jun 2021

Oral antidiabetic medication provides kidney protection in focal segmental glomerulosclerosis

Focal segmental glomerulosclerosis (FSGS) is a rare form of kidney inflammation (glomerulonephritis) in which the glomeruli become increasingly scarred (sclerotic), leading to progressive loss of kidney function.

7 Jun 2021

Farxiga approved in the US for the treatment of chronic kidney disease in patients at risk of progression with and without type-2 diabetes

Approval is the most significant advancement in the treatment of chronic kidney disease in more than 20 years. In DAPA-CKD Phase III trial, Farxiga demonstrated unprecedented reduction in the risk of the composite of worsening of renal function, end-stage kidney disease and cardiovascular or renal death.

From AstraZeneca 14 May 2021

FDA approval provides targeted treatment option for patients with rare DMD mutation

Today, the U.S. Food and Drug Administration granted approval for Amondys 45 (casimersen) injection for the treatment of Duchenne muscular dystrophy (DMD) in patients who have a confirmed mutation of the DMD gene that is amenable to exon 45 skipping (Exons are pieces of DNA that provide information for making proteins in a person's genome).

25 Feb 2021

Tumor's stiff-arm tactic limits the effectiveness of immunotherapeutics

In a paper just published in the Journal for the Immunotherapy of Cancer (doi:10.1136/jitc-2020-001712), Dr Herbert, Head of Discovery at InsideOutBio, asks whether cancer cells stiff-arm immune cells just like rugby players push off defenders from the other team.

15 Dec 2020

Women with kidney failure have low rates of contraceptive use, research finds

New research from the University of Cincinnati finds that women with kidney failure have low rates of contraceptive use.

12 Nov 2020

FDA approves new treatment option for patients with rare Duchenne muscular dystrophy mutation

Today, the U.S. Food and Drug Administration granted accelerated approval to Viltepso (viltolarsen) injection for the treatment of Duchenne muscular dystrophy (DMD) in patients who have a confirmed mutation of the DMD gene that is amenable to exon 53 skipping.

12 Aug 2020

Medieval medicine to tackle antibiotic resistance

Biofilm-associated infections are notoriously difficult to treat, and they also play a role in antibiotic resistance as more antimicrobials are urgently needed to treat biofilm-associated infections. These biofilms act as protective layers that prevent the antibiotics from reaching and destroying the targeted bacteria.

29 Jul 2020

Medieval remedy can help treat modern day infections

Antibiotic resistance is an increasing battle for scientists to overcome, as more antimicrobials are urgently needed to treat biofilm-associated infections.

28 Jul 2020

Repurposed drug for acute lung injury in COVID-19

Now, a new study addresses the possible use of an FDA-approved monoclonal antibody, called fostamatinib, a spleen tyrosine kinase inhibitor (SYK), to reduce the levels of mucin-1, a molecule associated with acute lung injury and acute respiratory distress syndrome (ARDS). People who have severe COVID-19 disease may develop ARDS.

2 Jul 2020

Low socioeconomic status associated with certain kidney diseases

A new study found an inverse association between socioeconomic status and certain kidney diseases. The findings appear in an upcoming issue of CJASN.

20 Feb 2020

Integral Molecular announces panel of P2X7 antibodies for autoimmune disorders

Integral Molecular, the leader in discovering antibodies against multipass membrane proteins, announces lead monoclonal antibodies (MAbs) against P2X7, a structurally complex ion channel that is the target for autoimmune disorders including atopic dermatitis and glomerulonephritis.

10 Jan 2020

Glomerulonephritis News and Research

Cellular and humoral responses and the safety of recombinant and inactivated SARS-CoV-2 vaccines in chronic kidney disease patients

Japanese study reveals increase in incidence rates of renal replacement therapy attributed to nephrosclerosis

Study finds low absolute risk of glomerular disease relapse associated with COVID-19 vaccination

Study shows glomerulonephritis after SARS-CoV-2 mRNA vaccination likely coincidental

Assessing the association of COVID-19 and Immunoglobulin A vasculitis in children

Study reports safety, efficacy of targeted treatment for IgA nephropathy

Oral antidiabetic medication provides kidney protection in focal segmental glomerulosclerosis

Farxiga approved in the US for the treatment of chronic kidney disease in patients at risk of progression with and without type-2 diabetes

FDA approval provides targeted treatment option for patients with rare DMD mutation

Tumor's stiff-arm tactic limits the effectiveness of immunotherapeutics

Women with kidney failure have low rates of contraceptive use, research finds

FDA approves new treatment option for patients with rare Duchenne muscular dystrophy mutation

Medieval medicine to tackle antibiotic resistance

Medieval remedy can help treat modern day infections

Repurposed drug for acute lung injury in COVID-19

Low socioeconomic status associated with certain kidney diseases

Integral Molecular announces panel of P2X7 antibodies for autoimmune disorders

Researchers propose genetic testing and continued management of identical twin kidney transplants

UC research finds racial differences among pregnant women on dialysis

UAB researchers find key role for IgG autoantibodies in IgA nephropathy

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