Hematology News and Research

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Hematology, also spelled haematology, is the branch of biology (physiology), pathology, clinical laboratory, internal medicine, and pediatrics that is concerned with the study of blood, the blood-forming organs, and blood diseases. Hematology includes the study of etiology, diagnosis, treatment, prognosis, and prevention of blood diseases.

Medicaid policies boost oncology clinical trial enrollment for Black and Hispanic patients

Two Medicaid policies can interact to increase oncology clinical trial enrollment among Black and Hispanic patients, according to a new study by investigators at Weill Cornell Medicine, the University of Pennsylvania, and Medidata AI.

25 Jul 2024

Study highlights infection as major post-CAR-T therapy challenge

In patients with diffuse large B-cell non-Hodgkin lymphoma (DLBCL), the two hallmark post-chimeric antigen receptor (CAR)-T therapy toxicities are extremely rare after two weeks, supporting a shorter, more flexible toxicity monitoring period, according to a study published in Blood Advances.

25 Jul 2024

Simple blood test may predict CAR-T therapy success in multiple myeloma

A simple blood test that measures the number of lymphocytes, a type of white blood cell in the body, may predict whether people who have relapsed multiple myeloma are going to respond well to CAR-T immunotherapy, according to new research from Weill Cornell Medicine, NewYork-Presbyterian, Columbia University and Icahn School of Medicine at Mount Sinai.

24 Jul 2024

CD5 knockout using CRISPR boosts CAR T cell therapy efficacy

The effectiveness of CAR T cell therapy against a variety of cancers, including solid tumors, could be boosted greatly by using CRISPR-Cas9 technology to knock out the gene for CD5, a protein found on the surface of T cells, according to a preclinical study from investigators at the University of Pennsylvania's Perelman School of Medicine and Abramson Cancer Center.

19 Jul 2024

Ovarian reserve unchanged by hydroxyurea in sickle cell disease, study reveals

In female patients living with sickle cell disease (SCD), hydroxyurea had no effect on ovarian reserve, suggesting that fertility preservation measures prior to treatment may be unnecessary, according to a study published in Blood Advances.

18 Jul 2024

Study uncovers how OTX2 drives aggressive childhood brain cancer

In a report published in Nature Cell Biology, researchers at Baylor College of Medicine, Texas Children's Hospital, the University of Manitoba and collaborating institutions revealed an unexpected way in which the protein OTX2 drives the progression of medulloblastoma – the most common aggressive childhood brain cancer.

18 Jul 2024

UC Irvine develops ePRO tool to improve cancer care for minority patients

A University of California, Irvine research team has developed and implemented an intervention to enhance cancer care support services for racial and ethnic minority patients undergoing chemotherapy.

16 Jul 2024

UCLA investigators receive $800,000 grant to treat and prevent aggressive kidney cancer

Investigators at the UCLA Health Jonsson Comprehensive Cancer Center have received an $800,000 grant from the V Foundation to find new ways to treat and prevent a severe form of kidney cancer associated with a hereditary syndrome caused by mutations in the fumarate hydratase (FH) gene.

16 Jul 2024

CD22-targeted CAR-T therapy shows promising results in relapsed large B-cell lymphoma

CAR-T cell therapy, which targets a specific protein on the surface of cancer cells, causes tumors to shrink or disappear in about half of patients with large B-cell lymphoma who haven't experienced improvement with chemotherapy treatments.

11 Jul 2024

Novel Co-STAR cells show promise in targeting and eradicating cancer

Using genetic engineering techniques, investigators at the Johns Hopkins Kimmel Cancer Center and its Ludwig Center, the Lustgarten Laboratory and Bloomberg~Kimmel Institute for Cancer Immunotherapy have designed a novel type of cell to recognize and fight cancer.

11 Jul 2024

Stem-like cells found to drive growth of aggressive pediatric brain tumors

A team of researchers at Baylor College of Medicine, Texas Children's Hospital, the Hospital for Sick Children in Toronto and collaborating institutions has identified and located a population of stem-like cells that initiates and maintains Group 3 medulloblastoma (Gr3-MB) in the developing brain.

9 Jul 2024

No organ is an island: Genetic study shows unique but interconnected aging markers

Researchers analyzed genetic underpinnings of biological age gaps in nine organ systems using a large dataset from the U.K. Biobank, revealing organ-specific yet interconnected genetic architectures. Their findings may aid in understanding complex diseases and developing holistic treatments.

2 Jul 2024

Early detection of aggressive multiple myeloma through molecular analysis

Multiple myeloma is one of the most common forms of cancer of the immune cells in the bone marrow. It is considered incurable.

1 Jul 2024

Hesse's LOEWE program supports cutting-edge CAR-T cell therapy research

LOEWE, the federal state of Hesse's research promotion program for the development of scientific and economic excellence, is providing €4.8 million in funding for a new research network spearheaded by Goethe University.

28 Jun 2024

Targeted gene therapy may reduce AML burden and protect the heart from cardiotoxicity

Researchers from the University of Missouri School of Medicine found that a targeted gene therapy may make acute myeloid leukemia (AML) more sensitive to chemotherapy, while also protecting the heart against toxicity often caused by cancer treatments.

27 Jun 2024

New curative treatment for sickle cell disease shows promising results in international trial

Vanderbilt University Medical Center (VUMC) researchers are touting data from a multicenter, international phase 2 clinical trial showing a new, curative treatment for sickle cell disease (SCD).

25 Jun 2024

JAK1 inhibition and Anti-PD1 therapy enhance outcomes in advanced lung cancer

Adding an anti-inflammatory drug to anti-PD1 checkpoint inhibitor immunotherapy has shown great promise as a new strategy against advanced lung cancer, based on results from a small clinical trial led by investigators at the Abramson Family Cancer Center at the University of Pennsylvania Perelman School of Medicine.

21 Jun 2024

Combination therapy shows great promise as a new strategy against advanced lung cancer

21 Jun 2024

Regular IgG monitoring and replacement therapy reduce severe infections in CLL and NHL patients

Patients with chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphomas (NHLs) who received frequent tests for immunoglobulin G (IgG) were less likely to experience severe infections compared with those who didn't, according to a study published in Blood Advances.

21 Jun 2024

AI outperforms peers in medical oncology quiz, yet some mistakes could be harmful

The accuracy and safety of large language models (LLMs) in answering medical oncology examination questions.

21 Jun 2024

Hematology News and Research

Further Reading

Medicaid policies boost oncology clinical trial enrollment for Black and Hispanic patients

Study highlights infection as major post-CAR-T therapy challenge

Simple blood test may predict CAR-T therapy success in multiple myeloma

CD5 knockout using CRISPR boosts CAR T cell therapy efficacy

Ovarian reserve unchanged by hydroxyurea in sickle cell disease, study reveals

Study uncovers how OTX2 drives aggressive childhood brain cancer

UC Irvine develops ePRO tool to improve cancer care for minority patients

UCLA investigators receive $800,000 grant to treat and prevent aggressive kidney cancer

CD22-targeted CAR-T therapy shows promising results in relapsed large B-cell lymphoma

Novel Co-STAR cells show promise in targeting and eradicating cancer

Stem-like cells found to drive growth of aggressive pediatric brain tumors

No organ is an island: Genetic study shows unique but interconnected aging markers

Early detection of aggressive multiple myeloma through molecular analysis

Hesse's LOEWE program supports cutting-edge CAR-T cell therapy research

Targeted gene therapy may reduce AML burden and protect the heart from cardiotoxicity

New curative treatment for sickle cell disease shows promising results in international trial

JAK1 inhibition and Anti-PD1 therapy enhance outcomes in advanced lung cancer

Combination therapy shows great promise as a new strategy against advanced lung cancer

Regular IgG monitoring and replacement therapy reduce severe infections in CLL and NHL patients

AI outperforms peers in medical oncology quiz, yet some mistakes could be harmful

E-Cigarettes and Ethanol: A forensic Perspective on Vaping

Understanding Consumer-Consented Data to Optimize Digital Health Programs

The Future is Wearable: Advancing Human Health Through Portable Spectroscopy

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